Development of Large Genital Ulcer Due to Hydroxyurea Treatment in a Patient with Chronic Myeloid Leukemia and Behcet's Disease

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative disease arising from abnormal stem cells and associated with splenomegaly and leukocytosis. Hydroxyurea and interferon alpha are used in treatment very frequently. Behcet's disease (BD) is a chronic, repetitive disease of unknown etiology and associated with mucocutaneous, ocular, vascular and central nervous system involvement. Cases with symptoms of BD have been reported during interferon alpha treatment of CML. However, similar symptoms due to hydroxyurea treatment have been reported in only one case until now. A 32-year-old female patient under follow up because of CML and BD, developed a large genital ulcer during hydroxyurea treatment. Ulcers due to hydroxyurea treatment and the co-existence of these two diseases has been reported in only one case in the literature while large genital ulcers have not been reported previously.

miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

“…THP-1 cells were obtained from the American Type Culture Collection and cultured in RPMI medium 1640 supplemented with 10% FBS, 1× nonessential amino acids, 100 U/ml penicillin, 100 U/ml streptomycin, and 2 mM glutamine in a humidified incubator containing 5% CO 2 at 37°C. BMDMs were differentiated from BM precursors in the presence of 50 ng/ml recombinant mouse M-CSF (PeproTech) according to protocol (Karincaoglu et al, 2003). BM-derived plasmacytoid dendritic cells were differentiated from BM cells by culturing in the presence of 100 ng/ml recombinant Flt3 protein for 8-10 d. B220 + dendritic cells were then sorted out using Miltenyi Biotech MicroBeads and stimulated with 5 μg/ml CpG for 24 h. LPS (Escherichia coli 055:B5) was obtained from Sigma-Aldrich.…”

Dermatoses of the Male Genital Area

“…The differential diagnosis is foscarnet-, hydroxyurea- and dequaline-induced ulcers, which must be excluded, furthermore ulcers in Crohn’s disease [23, 24, 25]. …”

Ulzerationen unter Therapie mit Hydroxyharnstoff

“…Orale Ulzera sind eher selten [20]. In Einzelfällen wurden Ulzerationen auch genital [16], postoperativ [30] und an den Handrücken [12] beschrieben. Die Pathogenese ist nicht geAbb.…”