Development of laboratory confocal 3D-XRF spectrometer and nondestructive depth profiling

Nakano, Kazuhiko; Tsuji, Kouichi

doi:10.1039/b916974a

Cited by 39 publications

(39 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…97, 126–129 CXRF defines a microscopic sample volume through which the sample is scanned utilizing polycapillary lenses composed of a bundle of hollow glass capillary tubes operating under total external reflection to focus the X-ray beam. 97, 127–130 The axial resolution of CXRF is determined by the resolution of the focusing lens and becomes poorer when imaging elements with low atomic numbers due to lens wavelength dependence.…”

Section: X-ray Fluorescence (Xrf)mentioning

confidence: 99%

See 1 more Smart Citation

Advances in functional X-ray imaging techniques and contrast agents

Chen

Rogalski

Anker

2012

Phys. Chem. Chem. Phys.

137

118

View full text Add to dashboard Cite

X-rays have been used for non-invasive high-resolution imaging of thick biological specimens since their discovery in 1895. They are widely used for structural imaging of bone, metal implants, and cavities in soft tissue. Recently, a number of new contrast methodologies have emerged which are expanding X-ray’s biomedical applications to functional as well as structural imaging. These techniques are promising to dramatically improve our ability to study in situ biochemistry and disease pathology. In this review, we discuss how X-ray absorption, X-ray fluorescence, and X-ray excited optical luminescence can be used for physiological, elemental, and molecular imaging of vasculature, tumours, pharmaceutical distribution, and the surface of implants. Imaging of endogenous elements, exogenous labels, and analytes detected with optical indicators will be discussed.

show abstract

Section: X-ray Fluorescence (Xrf)mentioning

confidence: 99%

“…130 The confocal arrangement reduces background intensity. 96, 129 However, self-absorption of X-ray fluorescence within a sample limits the imaging depth for low energy X-ray fluorescence. 127 …”

Section: X-ray Fluorescence (Xrf)mentioning

confidence: 99%

Advances in functional X-ray imaging techniques and contrast agents

Chen

Rogalski

Anker

2012

Phys. Chem. Chem. Phys.

137

118

View full text Add to dashboard Cite

show abstract

“…The potential for quantitative analysis in a microchip by confocal 3D-XRF was assessed using a custom polyethylene terephthalate microchip, which contained two overlapping channels. [8] Detection limits of 28 and 19 ng/μl were reported for Cu and Co, respectively. Both of these reports differ from the present work in that they are flow-based sampling systems.…”

Section: Introductionmentioning

confidence: 98%

Microfluidic sample preparation for elemental analysis in liquid samples using micro X‐ray fluorescence spectrometry

et al. 2014

View full text Add to dashboard Cite

The integration of microfluidic devices with micro X-ray fluorescence (micro-XRF) spectrometry offers a new approach for the direct characterization of liquid materials. A sample presentation method based on use of small volumes (<5 μl) of liquid contained in an XRF-compatible device has been developed. In this feasibility study, a prototype chip was constructed, and its suitability for XRF analysis of liquids was evaluated, along with that of a commercially produced microfluidic device. Each of the chips had an analytical chamber which contained approximately 1 μl of sample when the device was filled using a pipette. The performance of the chips was assessed using micro-XRF and high resolution monochromatic wavelength dispersive X-ray fluorescence, a method that provides highly selective and sensitive detection of actinides. The intended application of the device developed in this study is for measurement of Pu in spent nuclear fuel. Aqueous solutions and a synthetic spent fuel matrix were used to evaluate the devices. Sr, which has its Kα line energy close to the Pu Lα line at 14.2 keV, was utilized as a surrogate for Pu because of reduced handling risks. Between and within chip repeatability were studied, along with linearity of response and accuracy. The limit of detection for Sr determination in the chip is estimated at 5 ng/μl (ppm). This work demonstrates the applicability of microfluidic sample preparation to liquid characterization by XRF, and provides a basis for further development of this approach for elemental analysis within a range of sample types.

show abstract

“…Th e maximum depth of detection will vary, but it is generally only a few micrometers. Much deeper detection can be achieved with confocal three-dimensional XRF analysis (Nakano and Tsuji, 2010). Numerous limitations should be considered when using XRF for fi eld studies (USEPA, 2007).…”

Section: X-ray Fluorescence Spectrometrymentioning

confidence: 99%

Historical Perspective on the Tools That Helped Shape Soil Chemistry

Schulthess

2011

Soil Science Society of America Journal

View full text Add to dashboard Cite

SSSA 75 th Anniversary Paper T he tools of soil chemistry include instruments, mathematics, models, and software. Th ere is also the mind and imagination. Th roughout the history of our science, we have been shift ing away from a very labor-intensive laboratory environment, where long hours of concentration on tedious tasks was the norm. Th is change in the way we work has been accelerating, particularly since the 1950s. We are accomplishing more work but with less eff ort and more time to contemplate what the data are trying to tell us. Th e essence of our research activity has changed dramatically.Numerous laboratory tools have been used in soil chemistry during the last 200 yr, and the major changes that have occurred are highlighted here. It is hoped that the picture presented will help us decide how to better train our students for the future. By knowing how we have changed in the past and how we appear to be changing in the present, we can perhaps trace the path that we are taking, at least in the near future.Eight major themes are addressed here:1. Th e early years reviews the research environment of the 1800s up to the early 1900s. It marks the beginning years of soil chemistry that shaped many of our ideas for the decades that followed.2. Th e age of electronics covers the early part of the 1900s and the origins of the fi rst portable meters on the market.3. Spectroscopy is at the core of most of our modern methods of analysis. While the development of only a few tools are described here, the impact of spectroscopy on our current research activity cannot be understated.

show abstract

Development of laboratory confocal 3D-XRF spectrometer and nondestructive depth profiling

Cited by 39 publications

References 33 publications

Advances in functional X-ray imaging techniques and contrast agents

Advances in functional X-ray imaging techniques and contrast agents

Microfluidic sample preparation for elemental analysis in liquid samples using micro X‐ray fluorescence spectrometry

Historical Perspective on the Tools That Helped Shape Soil Chemistry

Contact Info

Product

Resources

About