Development of ionic strength/pH/enzyme triple-responsive zwitterionic hydrogel of the mixed <scp>l</scp>-glutamic acid and <scp>l</scp>-lysine polypeptide for site-specific drug delivery

Ma, Guanglong; Lin, Weifeng; Yuan, Zhefan; Wu, Jiang; Qian, Haofeng; Xu, Liangbo; Chen, Shengfu

doi:10.1039/c6tb02407f

Cited by 79 publications

(61 citation statements)

References 57 publications

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“…On the other hand, stimuli-responsive nanocarriers have shown the ability to control the release profile of drugs (as a triggered release) using external factors such as ultrasound [ 96 ], heat [ 97 – 99 ], magnetism [ 100 , 101 ], light [ 102 ], pH [ 103 ], and ionic strength [ 104 ], which can improve the targeting and allow greater dosage control (Fig. 2 ).…”

Section: Drug Designing and Drug Delivery Process And Mechanismmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner. Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines. Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc.) in the treatment of various diseases. The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (e.g., natural products) and selective diagnosis through disease marker molecules. The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed. In addition, we have included information regarding the trends and perspectives in nanomedicine area.

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Section: Drug Designing and Drug Delivery Process And Mechanismmentioning

confidence: 99%

Nano based drug delivery systems: recent developments and future prospects

et al. 2018

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“…[109][110][111] The microenvironment of free enzyme catalysis can be imitated by the hydrated hydrogel matrix, benefiting the mobility and flexibility of the immobilized enzymes, causing a high catalytic enzymatic activity. 111 Hydrogels gain space in biologically important areas such as drug delivery and release, [112][113][114] release of DNA, 115,116 entrapment and release of enzymes 117,118 and biosensor. 119 However, enzymes immobilized in hydrogels tend to pour out of the gel, because the enzyme is basically encapsulated in the small pores of the gel, against this, functional hydrogels utilize functional building blocks, such as proteins.…”

Section: Hydrogels and Enzymatic Applicationsmentioning

confidence: 99%

Design of Immobilized Enzyme Biocatalysts: Drawbacks and Opportunities

Reis

Sousa

Serpa

et al. 2019

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The enzymatic processes are increasingly highlights, especially in the synthesis of chemical products with high added value. The enzyme immobilization can improve industrial biocatalytic processes. The immobilization of enzymes provides the production of efficient, stable biocatalysts, possibility of reuse and easy purification of the products, when compared to the free enzymes. There is a growing research for more efficient methods of enzyme immobilization. In this context, the choice of support and immobilization strategy can significantly improve the final enzymatic properties. In this review paper, we aimed to discuss the versatility of biocatalysts immobilized enzymes design, focusing on the opportunities and disadvantages for each method presented. They discussed the recent development of enzyme immobilization methods and applications relating the final properties of the produced biocatalysts with the desired goals.

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“…[84][85][86] pH-, ion-, and protease-responsive poly(L-glutamic acidco-L-lysine) hydrogels were prepared by mixing poly(L-glutamic acid-co-L-lysine) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride followed by 5 min of gelation. 87 Since the pI of the copolymer is 6, the carboxylic acid and amine groups were protonated (accumulation of positive charges) and deprotonated (accumulation of negative charges) at pH < 6 and > 6, respectively. Therefore, the pH changes led to an increase in the swelling ratio of the hydrogels caused by charge repulsion in both cases.…”

Section: Triple-stimuli-responsive Hydrogelsmentioning

confidence: 99%

Multi-Stimuli-Responsive Polymer Particles, Films, and Hydrogels for Drug Delivery

Hosta‐Rigau

Chandrawati

et al. 2018

Chem

292

208

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Stimuli-responsive polymer materials are powerful tools in drug delivery and tissue engineering. Because of the large variations in physiological conditions between normal microenvironments and diseased sites, polymer materials with single responsiveness may not achieve the desired goals in a complex physiological microenvironment. Instead, polymer materials responsive to multiple physical or chemical stimuli are highly desired for biomedical applications (e.g., drug delivery). In this review, we highlight recent studies in multi-stimuli-responsive materials with a specific emphasis on polymer particles, films, and hydrogels. The synthetic strategies employed to produce these responsive materials are described. Applications in drug delivery are highlighted, followed by a discussion of the current research focus and future trends.

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Development of ionic strength/pH/enzyme triple-responsive zwitterionic hydrogel of the mixed l-glutamic acid and l-lysine polypeptide for site-specific drug delivery

Abstract: Environmentally responsive hydrogels for drug delivery.

Cited by 79 publications

References 57 publications

Nano based drug delivery systems: recent developments and future prospects

Nano based drug delivery systems: recent developments and future prospects

Design of Immobilized Enzyme Biocatalysts: Drawbacks and Opportunities

Multi-Stimuli-Responsive Polymer Particles, Films, and Hydrogels for Drug Delivery

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