Development of Integrated Backscatter Intravascular Ultrasound for Tissue Characterization of Coronary Plaques

Okubo, Munenori; Kawasaki, Masanori; Ishihara, Yoshiyuki; Takeyama, Urara; Kubota, Tomoki; Yamaki, Takashi; Ojio, Shinsuke; Nishigaki, Kazuhiko; Takemura, Genzou; Saio, Masanao; Takami, Taro; Minatoguchi, Shinya; Fujiwara, Hisayoshi

doi:10.1016/j.ultrasmedbio.2007.09.015

Cited by 93 publications

(56 citation statements)

References 24 publications

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“…In accordance with previous studies, IB values were defined as follows: -29 dB < IB for calcified tissue, -49 dB < IB !-29 dB for fibrous tissue, and -49 dB "IB for lipid tissue. 20,21) Applying the definition of the IB value for neointimal tissue components, the neointima was similarly classified according to the IB value.…”

Section: Methodsmentioning

confidence: 99%

Impact of Coronary Stent Fracture on Restenotic Neointimal Tissue Characterization After Drug-Eluting Stent Implantation

et al. 2017

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SummaryAlthough drug-eluting stents (DESs) reduce the rates of in-stent restenosis (ISR) and subsequent target lesion revascularization, stent fracture (SF) after DES implantation has become an important concern because of its potential association with restenosis and stent thrombosis. We aimed to assess the pathogenic impact of SF on in-stent restenotic neointimal tissue components after DES implantation. We analyzed 43 consecutive patients (14 with SF and 29 without SF) with ISR requiring revascularization after DES implantation between January 2008 and March 2014. For evaluation of in-stent tissue components, integrated backscatter intravascular ultrasound (IB-IVUS) was performed. SF was defined as complete or partial separation of stent segments observed using plain fluoroscopy or intravascular ultrasound. On volumetric IB-IVUS analyses, patients with SF had a significantly higher percentage of lipid tissue volume within the neointima and a significantly lower percentage of fibrous tissue volume than those without (37.3 ± 18.9% versus 24.9 ± 12.4%, P = 0.02, and 61.2 ± 18.3 versus 72.6 ± 12.1%, P = 0.04, respectively). Moreover, SF was positively correlated with the percentage of lipid volume on multiple linear regression analysis after adjustment for confounding factors (β = 0.36, P = 0.03). The interval from stent implantation was similar in both groups (47.0 ± 28.7 versus 37.7 ± 33.3 months; P = 0.39). In conclusion, SF is associated with larger lipid tissue volume within the neointima after DES placement, suggesting a contribution to the development of neoatherosclerosis and vulnerable neointima. Thus SF might lead to future adverse coronary events.(Int Heart J 2017; 58: 861-867)

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Section: Methodsmentioning

confidence: 99%

Impact of Coronary Stent Fracture on Restenotic Neointimal Tissue Characterization After Drug-Eluting Stent Implantation

et al. 2017

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“…However, a limitation resides in the fact that very dense fibrous lesions may produce sufficient reflectivity and attenuation or acoustic shadowing to be misclassified as calcified 136. Furthermore, Okubo et al137 showed that IB‐IVUS occasionally underestimated calcified lesions and overestimated lipid pools behind calcifications as a consequence of the acoustic shadowing resulting from the calcification. Moreover, the ability to detect ultrasonically hypoechoic microcalcification with IB‐IVUS is limited.…”

Section: Intravascular Imagingmentioning

confidence: 99%

Imaging Cardiovascular Calcification

Wang

Osborne

Tung

et al. 2018

JAHA

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“…12,15,27 In the histological comparison, histology/ IVUS image pairs were classified into 3 categories: calcific, fibrous and lipid-rich according to our previous studies. 12, 27 The inter-observer agreements of IB-IVUS for tissue characterization of plaque type were excellent (Cohen's κ=0.90). 26 In addition, we performed a "direct" comparison by setting small (0.3×0.3 mm) ROI at the same locations within the IVUS images.…”

Section: Ex Vivo Histological Validationmentioning

confidence: 99%

A Histological and Clinical Comparison of New and Conventional Integrated Backscatter Intravascular Ultrasound (IB-IVUS)

Ohota

Kawasaki

Ismail

et al. 2012

Circ J

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Background: While the utilization of integrated backscatter intravascular ultrasound (IB-IVUS) for the quantitative in vivo assessment of coronary plaque continues to grow, the validity of IB-IVUS images obtained from newly developed and conventional systems remains uncertain. Methods and Results:To assess the accuracy and reliability of a newly developed IB-IVUS system (VISIWAVE) as compared to the conventional system (Clearview), we compared quantitative IB-IVUS plaque characteristics in the 2 systems using 125 post-mortem specimens from 26 coronary arteries in 11 cadavers, as well as using 200 clinical plaques in 32 patients undergoing coronary intervention. The overall agreement between the histological and IB-IVUS diagnoses using VISIWAVE (Cohen's κ=0.82, 95%CI: 0.73-0.90) was similar to that using Clearview (Cohen's κ=0.80, 95%CI: 0.71-0.89). The 2 systems also demonstrated comparably high sensitivity and specificity. In the direct comparison, the overall agreement between IB-IVUS diagnoses using VISIWAVE and Clearview was also excellent (Cohen's κ=0.87, 95%CI: 0.78-0.95). In the clinical comparison, measured plaque dimensions were similar (VISIWAVE: 8.27±3.46 mm 2 vs. Clearview; 8.31±3.46 mm 2 , P=0.44) and there was strong concordance between both greyscale and IB-IVUS parameters. Conclusions:There was close agreement of analyzed results in both systems when compared with the gold standard of histology. Both systems are able to reliably and accurately characterize coronary plaque and thereby make a valuable contribution to our understanding of atherosclerosis. (Circ J 2012; 76: 1678 - 1686

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Development of Integrated Backscatter Intravascular Ultrasound for Tissue Characterization of Coronary Plaques

Cited by 93 publications

References 24 publications

Impact of Coronary Stent Fracture on Restenotic Neointimal Tissue Characterization After Drug-Eluting Stent Implantation

Impact of Coronary Stent Fracture on Restenotic Neointimal Tissue Characterization After Drug-Eluting Stent Implantation

Imaging Cardiovascular Calcification

A Histological and Clinical Comparison of New and Conventional Integrated Backscatter Intravascular Ultrasound (IB-IVUS)

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