Development of inhibitory circuitry in visual and auditory cortex of postnatal ferrets: Immunocytochemical localization of GABAergic neurons

Gao, Wenjun; Newman, Douglas E.; Wormington, Amy B.; Pallas, Sarah L.

doi:10.1002/(sici)1096-9861(19990628)409:2<261::aid-cne7>3.0.co;2-r

Cited by 61 publications

(52 citation statements)

References 55 publications

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“…Most importantly, they demonstrate that conductive impairment at a very early age may induce re-organization within auditory cortex, where CHL occurring later in development may promote a different mode or temporal sequence of cortical re-organization. These different modes may include potential plastic changes (e.g., Irvine, 2007) or perturbed expression of neurotransmitters or their receptors (e.g., Cherubini et al, 1991;Gao et al, 1999;Kilman et al, 2002;Yu et al, 2006). Regardless of the underlying mechanism, our main observation remains that in response to low frequency sound stimulation, CHL, but not CA, decreases activity in auditory cortex.…”

Section: Developmental Effects Of Unilateral Chlmentioning

confidence: 87%

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

Hutson¹,

Durham²,

Imig³

et al. 2008

Hearing Research

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The effect of unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied in post-natal day 21 gerbils. Three weeks following a unilateral conductive hearing loss (CHL) or cochlear ablation (CA), animals were injected with 2-DG and exposed to an alternating auditory stimulus (1 and 2 kHz tones). Uptake of 2-DG was measured in the inferior colliculus (IC), medial geniculate (MG), and auditory cortex (fields AI and AAF) of both sides of the brain in experimental animals and in anesthesia-only sham animals (SH). Significant differences in uptake, compared to SH, were found in the IC contralateral to the manipulated ear (CHL or CA) and in AAF contralateral to the CHL ear. We hypothesize that these findings may result from loss of functional inhibition in the IC contralateral to CA, but not CHL. Altered states of inhibition at the IC may affect activity in pathways ascending to auditory cortex, and ultimately activity in auditory cortex itself. Altered levels of activity in auditory cortex may explain some auditory processing deficits experienced by individuals with CHL.

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Section: Developmental Effects Of Unilateral Chlmentioning

confidence: 87%

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

Hutson¹,

Durham²,

Imig³

et al. 2008

Hearing Research

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show abstract

“…Density of GABA-stained neurons in the auditory cortex peaks in late development and actually diminishes across the progression into adulthood (30). Inputs from pyramidal neurons that project long-range horizontal connections across auditory and visual cortices (31)(32)(33) and exuberance of cortical connections can perhaps account for the broad spectral integration observed at young ages.…”

Section: Discussionmentioning

confidence: 99%

Development of spectral and temporal response selectivity in the auditory cortex

Chang

Bao²,

Imaizumi³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

149

160

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The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing inhibitory influences on the refinement of spectral and temporal response properties in the primary auditory cortex. Inhibitory receptive fields (IRFs) of infant rat auditory cortical neurons were spectrally far broader and had extended over far longer duration than did those of adults. The selective refinement of IRFs was delayed relative to that of excitatory receptive fields by an Ϸ2-week period that corresponded to the critical period for plasticity. Local application of a GABA A receptor antagonist revealed that intracortical inhibition contributes to this progressive receptive field maturation for response selectivity in frequency. Conversely, it had no effect on the duration of IRFs or successive-signal cortical response recovery times. The importance of exposure to patterned acoustic inputs was suggested when both spectral and temporal IRF maturation were disrupted in rat pups reared in continuous, moderate-intensity noise. They were subsequently renormalized when animals were returned to standard housing conditions as adults.

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“…The slow emergence of adult-like direction selectivity may result from the shaping of LFI properties by experience (Gao et al, 1999;Chang et al, 2005;Hensch and Fagiolini, 2005). One possible mechanism driving experience-dependent development of direction selectivity is spiketiming-dependent plasticity (STDP).…”

Section: Discussionmentioning

confidence: 99%

Development of Inhibitory Mechanisms Underlying Selectivity for the Rate and Direction of Frequency-Modulated Sweeps in the Auditory Cortex

Razak¹,

Fuzessery²

2007

J. Neurosci.

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Although it is known that neural selectivity for species-specific vocalizations changes during development, the mechanisms underlying such changes are not known. This study followed the development of mechanisms underlying selectivity for the direction and rate of frequency-modulated (FM) sweeps in the auditory cortex of the pallid bat, a species that uses downward FM sweeps to echolocate. In the adult cortex, direction and rate selectivity arise as a result of different spectral and temporal properties of low-frequency inhibition (LFI) and high-frequency inhibition (HFI). A narrow band of delayed HFI shapes rate selectivity for downward FM sweeps. A broader band of early LFI shapes direction selectivity. Here we asked whether these differences in LFI and HFI are present at the onset of hearing in the echolocation range or whether the differences develop slowly. We also studied how the development of properties of inhibitory frequencies influences FM rate and direction selectivity. We found that adult-like FM rate selectivity is present at 2 weeks after birth, whereas direction selectivity matures 12 weeks after birth. The different developmental time course for direction and rate selectivity is attributable to the differences in the development of LFI and HFI. Arrival time and bandwidth of HFI are adult-like at 2 weeks. Average arrival time of LFI gradually becomes faster and bandwidth becomes broader between 2 and 12 weeks. Thus, two properties of FM sweeps that are important for vocalization selectivity follow different developmental time courses attributable to the differences in the development of underlying inhibitory mechanisms.

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Development of inhibitory circuitry in visual and auditory cortex of postnatal ferrets: Immunocytochemical localization of GABAergic neurons

Cited by 61 publications

References 55 publications

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

Development of spectral and temporal response selectivity in the auditory cortex

Development of Inhibitory Mechanisms Underlying Selectivity for the Rate and Direction of Frequency-Modulated Sweeps in the Auditory Cortex

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