In article, reasons for feasibility of formation of an innovative hub are given in the Far Eastern Federal District of Russia, through collaboration of innovative, research and development and scientific and educational infrastructure of the region. The factors influencing overall performance of an innovative hub are considered. By means of mathematical simulation, the system of an indistinct output and the adaptive neuro and indistinct system of an output for assessment of efficiency of an innovative hub in case of the different amount of financing of the elements entering it were constructed. Based on theoretical researches expected quantitative results of activities of elements of a hub which were collocated to its efficiency expressed in points of 0-10 are revealed. Reasons for use of system of an indistinct output for determination of dependence of efficiency of an innovative hub on volume of the investments enclosed in it are result of operation.