Development of increased convulsibility in mice after a single norbornan injection

Golovko, A. I.; Иванов, М. Б.; Klyuntina, T. V.; Sofronov, G. A.; Sviderskii, O. A.; Шилов, В. В.

doi:10.1007/bf02764378

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1998

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(3 citation statements)

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“…We previously demonstrated that single injection of NB in a dose equal to LD~6 (0.095 mg/kg) to albino mice increases their sensitivity to picrotoxin and 3-mercaptopropionic acid toxicity [2]. These data led us to a conclusion on the crucial role of postsynaptic GABAA-ergic structures in this phenomenon.…”

Section: Resultsmentioning

confidence: 88%

“…Norbornan is a convulsant, an irreversible blocker of GABA A receptor chlorine channels [2,3]. It has been previously demonstrated that single injection of NB to albino mice led to sustained sensitization to picrotoxin and 3-mercaptopropionic acid toxicity [2].…”

mentioning

confidence: 99%

“…Norbornan (NB, exo,cis-5,6-dichloro-2,2-dicyano-3,3-bis-(trifluoromethyl)-norbornane; bicycloheptane) is a useful tool to study the mechanisms of kindling [1,3]. Norbornan is a convulsant, an irreversible blocker of GABA A receptor chlorine channels [2,3]. It has been previously demonstrated that single injection of NB to albino mice led to sustained sensitization to picrotoxin and 3-mercaptopropionic acid toxicity [2].…”

mentioning

confidence: 99%

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