Development of inactivated trivalent vaccine for the teratogenic Aino, Akabane and Chuzan viruses

Kim, Yeon-Hee; Kweon, Chang-Hee; Tark, Dongseob; Lim, Seong In; Yang, Dong-Kun; Hyun, Bang-Hun; Song, Jae‐Young; Hur, Won; Park, Taesung

doi:10.1016/j.biologicals.2011.02.004

Cited by 52 publications

(57 citation statements)

References 23 publications

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“…This virus infection is closely related to the Akabane and SBV infection; therefore, confirmatory diagnosis requires viral detection to differentiate infection between these three viruses [98]. Aino virus is transmitted between animals by insect vectors from Culicoides genus mosquitoes [90,95].…”

Section: • Aino Virusmentioning

confidence: 99%

“…Cache Valley virus (CVV) is a mosquito-borne [100], teratogenic Bunyavirus in the Orthobunyavirus genus of the Bunyamwera group [1,101], affecting mainly sheep [106]. Previous studies describing experimental CVV-induced malformations in ovine foetuses showed that the development of foetal lesions is age-dependent.…”

Section: • Cache Valley Virusmentioning

confidence: 99%

“…Chuzan virus is transmitted between animals by insect vectors such as Culicoides spp. [105][106][107] and is considered a teratogen virus once pregnant cows result in foetal congenital abnormalities [96,108,109]. Chuzan virus infection in adult animals is subclinical; however, foetal abnormalities in newborn calves infected with Chuzan virus during gestation can exhibit a wide range of skeletal and neurological abnormalities [106].…”

Section: • Chuzan Virusmentioning

confidence: 99%

“…[105][106][107] and is considered a teratogen virus once pregnant cows result in foetal congenital abnormalities [96,108,109]. Chuzan virus infection in adult animals is subclinical; however, foetal abnormalities in newborn calves infected with Chuzan virus during gestation can exhibit a wide range of skeletal and neurological abnormalities [106]. The most common clinical signs in deformed calves are arthrogryposis, vertebral malformations, brachygnathia inferior and malformations of the central nervous system, including hydranencephaly, porencephaly, hydrocephalus, cerebellar hypoplasia and micromyelia [110].…”

Section: • Chuzan Virusmentioning

confidence: 99%

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Epidemiology and Emergence of Schmallenberg Virus Part 1: Origin, Transmission and Differential Diagnosis

Esteves¹,

Mesquita²,

Nóbrega³

et al. 2016

Epidemiology of Communicable and Non-Communicable Diseases - Attributes of Lifestyle and Nature on Humankind

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Schmallenberg virus (SBV) is a novel Orthobunyavirus causing mild clinical signs in cows and malformations in aborted and neonatal ruminants in Europe. SBV belongs to the family Bunyaviridae and is transmitted by biting midges. This new virus was identified for the first time in the blood samples of cows in the city of Schmallenberg in NorthRhine-Westphalia in November 2011. Since then the virus spread to several European countries. Here we describe the origin and emergence, as well as the transmission and the differential diagnosis of this virus, now known to be a serious threat to Veterinary Public Health.

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Section: • Aino Virusmentioning

confidence: 99%

Section: • Cache Valley Virusmentioning

confidence: 99%

Section: • Chuzan Virusmentioning

confidence: 99%

Section: • Chuzan Virusmentioning

confidence: 99%

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Epidemiology and Emergence of Schmallenberg Virus Part 1: Origin, Transmission and Differential Diagnosis

Esteves¹,

Mesquita²,

Nóbrega³

et al. 2016

Epidemiology of Communicable and Non-Communicable Diseases - Attributes of Lifestyle and Nature on Humankind

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“…Inactivated and attenuated virus vaccines have been shown to be effective for other Simbu serogroup viruses. [84][85][86] It is also likely that the Schmallenberg virus NSs knockout mutant viruses could be the basis for an effective vaccine. 40,87 Clone 13, a naturally occurring NSs deletion mutant of the Rift Valley fever virus has been demonstrated to be an effective vaccine candidate in sheep and cattle.…”

Section: Future Control Measuresmentioning

confidence: 99%

Schmallenberg virus: continuing a trend?

Noad¹,

Brownlie²

2013

VAAT

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Abstract:Since its first isolation in Germany in 2011 the Schmallenberg strain of the Sathuperi virus has been detected across northern Europe. The virus is associated with neurological disease, abortion, and congenital deformities in ruminants, particularly among sheep and cattle. The rapid dissemination of the pathogen is reminiscent of the transmission of another midge-borne arbovirus, Bluetongue virus, which also spread to Europe on several separate occasions between 1998 and 2007. In this review we detail the characteristic features of the Schmallenberg virus and consider whether the virus highlights a European vulnerability for other midge-transmitted pathogens.

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Role of cervids in the epidemiology of bovine ephemeral fever virus infection in the Republic of Korea: A cross‐sectional retrospective study

Yeh

2022

Veterinary Medicine & Sci

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Background Bovine ephemeral fever (BEF) is a viral disease in cattle and buffaloes, with subclinical involvement in various ruminant species. Objectives This study aimed to investigate bovine ephemeral fever virus (BEFV) transmission in deer in the Republic of Korea (ROK) and the potential risk factors associated with seropositivity. Methods We conducted a retrospective cross‐sectional serological survey of neutralising antibodies against BEFV in cervid sera collected from the ROK. Results The seroprevalence of BEFV was estimated to be 10.8% (95% confidence interval [CI] = 8.5–14.1), demonstrating that exposure to this virus is prevalent among farmed and free‐ranging cervids in the ROK. The results revealed that age class and geographic location affected seroprevalence. Older age and the presence of neighbouring ruminant farms were significant risk factors (odds ratio [OR] = 2.394, 95% CI = 1.195–4.796) and (OR = 1.533, 95% CI = 1.026–2.288), respectively. We also observed that the individual likelihood of positivity in the southern provinces was significantly higher than that in the northern provinces (OR = 1.744, 95% CI = 1.001–3.037). There were also significant differences in the seroprevalence of cervids between the western and eastern provinces (OR = 2.021, 95% CI = 1.047–3.900). Factors that were not significantly associated with BEFV antibody prevalence included herd size and species ( p > 0.05). Conclusions These results suggest that cervid species may serve as important reservoirs for the transmission of BEFV, highlighting the need for closer monitoring of BEFV infections in cervids in the ROK.

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Development of inactivated trivalent vaccine for the teratogenic Aino, Akabane and Chuzan viruses

Cited by 52 publications

References 23 publications

Epidemiology and Emergence of Schmallenberg Virus Part 1: Origin, Transmission and Differential Diagnosis

Epidemiology and Emergence of Schmallenberg Virus Part 1: Origin, Transmission and Differential Diagnosis

Schmallenberg virus: continuing a trend?

Role of cervids in the epidemiology of bovine ephemeral fever virus infection in the Republic of Korea: A cross‐sectional retrospective study

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