Development of in situ ion selective sensors for dissolution

Bohets, Hugo; Vanhoutte, Koen; Maesschalck, Roy De; Cockaerts, P; Vissers, Bert; Nagels, L.J.

doi:10.1016/j.aca.2006.07.079

Cited by 38 publications

(25 citation statements)

References 32 publications

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“…The results illustrate that the modification via electro-deposition has increased the QCM affinity for Hg compared to the non-modifed QCM. It is well known that sensitivity is analyte concentration dependent [9,10]. The sensitivity of the electro-deposited device is shown to be 157, 180 and 212% larger than the nonmodified for the three tested concentrations of 3.65, 5.70 and 10.55mg/m 3 Hg, respectively.…”

Section: Resultsmentioning

confidence: 89%

Electro-deposition of gold nano-structures on gold Quartz Crystal Microbalance (QCM) electrodes for enhanced mercury vapour sensitivity in the presence of interferent gases

Sabri

Ippolito

Tardio

et al. 2008

2008 International Conference on Nanoscience and Nanotechnology

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Section: Resultsmentioning

confidence: 89%

Electro-deposition of gold nano-structures on gold Quartz Crystal Microbalance (QCM) electrodes for enhanced mercury vapour sensitivity in the presence of interferent gases

Sabri

Ippolito

Tardio

et al. 2008

2008 International Conference on Nanoscience and Nanotechnology

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“…It is difficult to expect that an array of poorly working sensor will behave better than one ISE with high selectivity to analyte. Nevertheless surprises the amount of publications where different solid-contact ISEs (SCE) or coated wire electrodes (CWE) [139][140][141][142][143][144][145][146][147]86] or even pure metals [148][149][150][151] are used as potentiometric sensor array elements. As it was discussed earlier in the text, most of the SCE [13] and CWE [17] have poor stability due to the absence of a thermodynamically defined reversibility at the membrane/solid-contact interface and many reviews on potentiometric sensors state limited practical application of such electrodes [152,76].…”

Section: Applications Of Potentiometric Sensor Arraysmentioning

confidence: 98%

Recent trends in potentiometric sensor arrays—A review

Bratov

Abramova

Ipatov

2010

Analytica Chimica Acta

221

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“…The cylindrical body (10 mm diameter) of the working electrode consists of Delrin (Dupont). It contains a cylindrical substrate electrode (3 mm diameter), which is an electronically conducting material such as glassy carbon (glassy carbon coated-wire electrode (CW)), or a graphite/PVC composite (Comp) [19]. The substrate electrode is coated with a PVC-based liquid membrane (so-called "coated wire" electrodes [18 -22]).…”

Section: Substrate Electrodesmentioning

confidence: 99%

“…To obtain the composite graphite/PVC substrate electrode, a suspension of 60% graphite and 40% high molecular weight PVC in THF (1 vol of graphite/PVC per 3 vol of THF) was applied in a cylindrical hole (3 mm diameter, 2 mm depth) at the sensing end of the working electrode. After drying, the graphite/PVC was polished with a 0.5 lm grid polishing sheet (3 M, St. Paul, MN, USA) [19]. The PVC-based coating was applied on this polished substrate electrode (see Section 2.3.2).…”

Section: Substrate Electrodesmentioning

confidence: 99%

Unique potentiometric detection systems for HPLC determination of some steroids in human urine

Vissers¹,

Everaert²,

Sekuła³

et al. 2009

J of Separation Science

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Unique potentiometric detection systems for HPLC determination of some steroids in human urineIsocratic HPLC with potentiometric detection is used for the determination of some 17-ketosteroids (17-KS), e.g., androsterone, dehydroepiandrosterone and estrone, and their respective sulfated conjugates (17-KSS). Glassy carbon or composite electrodes containing a mixture of graphite and poly(vinyl chloride), PVC, were used as substrate electrodes. These substrates were covered either by montmorillonite or potassium tetrakis(p-chlorophenyl) borate containing PVC-based rubber phase membranes. The neutral 17-KS compounds were derivatized with Girard's reagent P (GP) to obtain cationic pyridinium acetohydrazones prior to the HPLC/potentiometric detection assay. No side reactions were observed, and the GP itself was not interfering. The method yielded accurate and reproducible results and was applicable to samples containing down to micromolar concentrations. Next, the 17-KSS compounds, acting as anionic charged molecules, were determined directly in human urine samples with the HPLC/potentiometry combination without preliminary derivatization. For this purpose, a new anion-sensitive potentiometric electrode was developed using a macrocyclic polyamine containing, PVC-based, rubber phase membrane. The three 17-KSS compounds were also determined accurately down to micromolar concentrations. Especially, the main androgen metabolites as dehydroepiandrosterone sulfate and androsterone sulfate could be selectively determined with a developed potentiometric sensor in human urine samples without time-consuming cleanup and preconcentration step. IntroductionThe 17-ketosteroids (17-KS) are steroids with a ketone functional group at position 17 in their polycyclic carbon skeleton. Typical examples are dehydroepiandrosterone (DHEA), estrone (E 1 ), and androsterone (AD), see Scheme (1) for their structures. DHEA, a representative 17-KS, is synthesized by the adrenal gland and then converted into active hormones, estrogens, and androgens, in the peripheral tissues. Most of the DHEA (over 99%) is present in the blood as the sulfated conjugate (dehydroepiandrosterone sulfate (DHEAS)), which is second to cholesterol in abundance for circulating steroids in humans. In both sexes, serum DHEA levels vary profoundly throughout life. Levels start to increase in children, peakCorrespondence: Professor Grzegorz Bazylak, Department of Pharmaco-Bromatology & Molecular Nutrition, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jagiellonska 13, PL-85-067 Bydgoszcz, Poland E-mail: gbazylak@cm.umk.pl Fax: +4852-585-3817Abbreviations: AD, androsterone; AD-GP, androsterone derivatized with Girard's reagent P; ADS, androsterone sulfate; BOR_-Comp, TCPB containing graphite/PVC composite electrode used in repeated over several days measurements of sequence of different injected concentration of the analyte; BOR_Comp_1-day, TCPB containing graphite/PVC composite electrode used in consequtive measurements of the same injected concent...

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Development of in situ ion selective sensors for dissolution

Cited by 38 publications

References 32 publications

Electro-deposition of gold nano-structures on gold Quartz Crystal Microbalance (QCM) electrodes for enhanced mercury vapour sensitivity in the presence of interferent gases

Electro-deposition of gold nano-structures on gold Quartz Crystal Microbalance (QCM) electrodes for enhanced mercury vapour sensitivity in the presence of interferent gases

Recent trends in potentiometric sensor arrays—A review

Unique potentiometric detection systems for HPLC determination of some steroids in human urine

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