Development of Improved Process with Treatment of Cellulase for Isolation of Ampelopsin from Dried Fruits of Ampelopsis grossedentata

Gao, Wa; Lee, Sang-Un; Li, Jianghong; Lee, Jin Woo

doi:10.15376/biores.11.1.2712-2722

Cited by 12 publications

(8 citation statements)

References 23 publications

(35 reference statements)

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“…Dihydromyricetin (3,5,7,3 ′ ,4 ′ ,5 ′ -hexahydroxy-2,3-dihydroflavonol (DHM)) ( Figure 1), also known as ampelopsin, is a major flavonoid extracted from the leaves and stems of A. grossedentata. The content of DHM in A. grossedentata ranges from 30% to 40% (dry weight), which is considered to have the highest flavonoid content in natural plants [1]. Several scientific investigations reported that DHM possesses various biological activities such as anti-inflammatory [2,3], antioxidative [4,5], anticancer [6,7], antidiabetic [8][9][10], antiatherosclerosis [11,12], and cardioprotective effects [13,14].…”

Section: Introductionmentioning

confidence: 99%

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Chen

Shi

et al. 2021

Mediators of Inflammation

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Dihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese Traditional Medicine. It has attracted considerable attention from consumers due to its beneficial properties including anticancer, antioxidative, and anti-inflammatory activities. Continuous oxidative stress caused by intracellular redox imbalance can lead to chronic inflammation, which is intimately associated with the initiation, promotion, and progression of cancer. DHM is considered a potential redox regulator for chronic disease prevention, and its biological activities are abundantly evaluated by using diverse cell and animal models. However, clinical investigations are still scanty. This review summarizes the current potential chemopreventive effects of DHM, including its properties such as anticancer, antioxidative, and anti-inflammatory activities, and further discusses the underlying molecular mechanisms of DHM in cancer chemoprevention by targeting redox balance and influencing the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Chen

Shi

et al. 2021

Mediators of Inflammation

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“…DMY was first isolated from Ampelopsis meliaefolia by Kotake and Kubota in 1940, and was later reported as a major bioactive component in A. grossedentata (Zhang, Yang, & Xiong, 2001;Kou & Chen, 2012). The content of DMY was as high as 30-40% (w/w) in A. grossedentata (Tian, Zhang, Yang, Yang, & Gong, 2002;Gao, Lee, Li, & Lee, 2016). Other major sources of DMY also include medical plants such as Hovenia dulcis (Yoo, Mun, & Kim, 2006;Chaturvedula & Ruo, 2013) and Cedrus deodara (Liang, Shen, et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

Liú

Mao

Ding

et al. 2019

Trends in Food Science & Technology

105

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Background: Dihydromyricetin (DMY) is an important plant flavonoid, which has received great attention due to its health-benefiting activities, including antioxidant, antimicrobial, anti-inflammatory, anticancer, antidiabetic and neuroprotective activities. DMY capsules have been sold in US as a nutraceutical supplement to prevent alcoholic hangovers. The major disadvantage associated with DMY is its chemical instability and poor bioavailability caused by the combined effects of its low solubility and poor membrane permeability. This limits its practical use in the food and pharmaceutical fields. Scope and approach: The present paper gives an overview of the current methods for the identification and quantification of DMY. Furthermore, recent findings regarding the main biological properties and chemical stability of DMY, the metabolism of DMY as well as different approaches to increase DMY bioavailability in both aqueous and lipid phases are discussed. Key findings and conclusions: Current trends on identification and quantification of DMY have been focused on spectral and chromatographic techniques. Many factors such as heat, pH, metal ions, could affect the chemical stability of DMY. Despite the diverse biological effects of DMY, DMY faces with the problem of poor bioavailability. Utilization of different delivery systems including solid dispersion, nanocapsule, microemuslion, cyclodextrin inclusion complexes, co-crystallization, phospholipid complexes, and chemical or enzymatic acylation has the potential to improve both the solubility and bioavailability. DMY digested in laboratory animals undergoes reduction, dehydroxylation, methylation, glucuronidation, and sulfation. Novel DMY delivery systems and basic pharmacokinetic studies of encapsulated DMY on higher animals and humans might be required in the future.

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“…Cellulase is one of the common used hydrolytic enzymes to hydrolyze and decompose the components of cell wall and enhance the release of intracellular constituents (Fu et al, 2008). Furthermore, cellulase has been proved to be efficient for the extraction of flavonoids from different kinds of plant materials including Illicium verum (Huang et al, 2016), Ampelopsis grossedentata (Gao et al, 2016), Larix gmelini (Wang et al, 2011) and Geranium sibiricum L. (Yang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Cellulase-Assisted Extraction of Total Flavonoids from Corn Bract and Evaluation of Antioxidant and Antibacterial Aactivities

Yang¹,

Lü²,

Ben³

et al. 2019

American Journal of Biochemistry and Biotechnology

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Corn bract is a corn-based agricultural waste material that distributed worldwide. In present work, response surface methodology was applied to optimize the cellulase-assisted extraction of Total Flavonoids from Corn Bract (TFCB), the in vitro antioxidant and antibacterial as well as the in vivo antioxidant activities of TFCB were investigated. Results showed that the optimal conditions for TFCB extraction were as follows: Amount of cellulase, 0.4% (w/w); incubation time, 2 h; liquid-to-solid ratio, 35: 1 mL/g; ethanol concentration, 71% (v/v); TFCB yield was 1.284±0.01%, which was 25.39% higher than that of heat reflux extraction. In addition, when compared with vitamin C, TFCB showed weaker in vitro free radical-scavenging capacities, but stronger antioxidant activities in mice. Moreover, TFCB also exerted certain inhibitory effects against Gram-positive bacteria. This study will provide an evidence for the potential of comprehensive utilization of discarded corn bract.

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Development of Improved Process with Treatment of Cellulase for Isolation of Ampelopsin from Dried Fruits of Ampelopsis grossedentata

Cited by 12 publications

References 23 publications

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Dihydromyricetin: A review on identification and quantification methods, biological activities, chemical stability, metabolism and approaches to enhance its bioavailability

Optimization of Cellulase-Assisted Extraction of Total Flavonoids from Corn Bract and Evaluation of Antioxidant and Antibacterial Aactivities

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