Development of <i>Acanthocheilonema viteae</i> in <i>Meriones shawi</i>: Absence of microfilariae and production of active ES‐62

Lumb, Felicity E.; Doonan, James; Corbet, Marlene; Pineda, Miguel A.; Harnett, Margaret M.; Harnett, William

doi:10.1111/pim.12803

Cited by 1 publication

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References 16 publications

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“…The parasite is transmitted via the tick Ornithodorus tartakovskyi . Under laboratory conditions, the parasite can also infect other rodents, such as the Mongolian jird Meriones unguiculatus (Johnson et al 1974 ), the golden hamster Mesocricetus auratus (Pacheco 1970 ; Neilson and Forrester 1975 ), rats, the multimammate rat Mastomys nataliensis (Holdstock 1974 ; Sänger and Lämmler 1979 ), and to a limited extend mouse strains (Haque et al 1980; Storey et al 1989 ) as well as Shaw’s jird Meriones shawi (Lumb et al 2020 ). A. viteae adult worms reside in the subcutaneous tissue and start releasing microfilariae (MF) 6–9 weeks postinfection.…”

Section: Human Filarial Speciesmentioning

confidence: 99%

Human filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model

et al. 2021

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Filariae are vector-borne parasitic nematodes that are endemic worldwide, in tropical and subtropical regions. Important human filariae spp. include Onchocerca volvulus, Wuchereria bancrofti and Brugia spp., and Loa loa and Mansonella spp. causing onchocerciasis (river blindness), lymphatic filariasis (lymphedema and hydrocele), loiasis (eye worm), and mansonelliasis, respectively. It is estimated that over 1 billion individuals live in endemic regions where filarial diseases are a public health concern contributing to significant disability adjusted life years (DALYs). Thus, efforts to control and eliminate filarial diseases were already launched by the WHO in the 1970s, especially against lymphatic filariasis and onchocerciasis, and are mainly based on mass drug administration (MDA) of microfilaricidal drugs (ivermectin, diethylcarbamazine, albendazole) to filarial endemic areas accompanied with vector control strategies with the goal to reduce the transmission. With the United Nations Sustainable Development Goals (SDGs), it was decided to eliminate transmission of onchocerciasis and stop lymphatic filariasis as a public health problem by 2030. It was also requested that novel drugs and treatment strategies be developed. Mouse models provide an important platform for anti-filarial drug research in a preclinical setting. This review presents an overview about the Litomosoides sigmodontis and Acanthocheilonema viteae filarial mouse models and their role in immunological research as well as preclinical studies about novel anti-filarial drugs and treatment strategies.

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Section: Human Filarial Speciesmentioning

confidence: 99%

Human filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model

et al. 2021

View full text Add to dashboard Cite

show abstract

Development of Acanthocheilonema viteae in Meriones shawi: Absence of microfilariae and production of active ES‐62

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 16 publications

Human filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model

Human filariasis—contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model

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