“…The bonds around 2925, 2815, 1384, 1650 cm −1 are related to the vitamin D3. Figure 1(c) (Vit D3) confirmed this result 19,33,34 . According to the Figure 1(b), the peaks around 1722, 1287, 1380and 1450 cm −1 are related to the carbonyl, ester and alkyl functional groups of PHB 23 .…”
Section: Resultssupporting
confidence: 68%
“…Figure 1(c) (Vit D3) confirmed this result. 19,33,34 According to the Figure 1(b), the peaks around 1722, 1287, 1380and 1450 cm À1 are related to the carbonyl, ester and alkyl functional groups of PHB. 23 On the other hand, the bonds around 1624 and 1707 cm À1 related to the carboxyl groups of ciprofloxacin.…”
Periodontal tissue engineering has made a tremendous change in the treatment of periodontal disease. In this study, electrophoresed poly-hydroxy-butyrate (PHB) scaffold, beta-three calcium phosphate (β-TCP) nano powder in 3, 5 and 7% wt, ciprofloxacin antibiotics, and vitamin D3 as the major materials along with electrospinning method are selected for remaking the scaffold. The fibers are smooth and beads-free and have a good diameter (around 700 nm) and porosity (above 80%) indicates ideal conditions for the treatment of damaged tissue. The membrane with 5% ceramic has been selected as ideal membrane. The mention membrane has suitable mechanical properties. Studies have shown that adding ciprofloxacin to the membrane increases the rate of hydrophilicity. The addition of β-TCP nano powder increased the bioactivity of this membrane. In terms of the drug release of ciprofloxacin and vitamin D3, 45% and 60% of drugs released within the first 24 h which in turn it shows the ability of the drugs controlled deliveration by the membrane. Accordingly, it could be concluded that this bilayer composite membrane with high bioactivity, high hydrophilicity, suitable mechanical properties, suitable morphology, and appropriate porosity has the ideal conditions for increased bone growth as well as proliferation and treatment the periodontal disease.
“…The bonds around 2925, 2815, 1384, 1650 cm −1 are related to the vitamin D3. Figure 1(c) (Vit D3) confirmed this result 19,33,34 . According to the Figure 1(b), the peaks around 1722, 1287, 1380and 1450 cm −1 are related to the carbonyl, ester and alkyl functional groups of PHB 23 .…”
Section: Resultssupporting
confidence: 68%
“…Figure 1(c) (Vit D3) confirmed this result. 19,33,34 According to the Figure 1(b), the peaks around 1722, 1287, 1380and 1450 cm À1 are related to the carbonyl, ester and alkyl functional groups of PHB. 23 On the other hand, the bonds around 1624 and 1707 cm À1 related to the carboxyl groups of ciprofloxacin.…”
Periodontal tissue engineering has made a tremendous change in the treatment of periodontal disease. In this study, electrophoresed poly-hydroxy-butyrate (PHB) scaffold, beta-three calcium phosphate (β-TCP) nano powder in 3, 5 and 7% wt, ciprofloxacin antibiotics, and vitamin D3 as the major materials along with electrospinning method are selected for remaking the scaffold. The fibers are smooth and beads-free and have a good diameter (around 700 nm) and porosity (above 80%) indicates ideal conditions for the treatment of damaged tissue. The membrane with 5% ceramic has been selected as ideal membrane. The mention membrane has suitable mechanical properties. Studies have shown that adding ciprofloxacin to the membrane increases the rate of hydrophilicity. The addition of β-TCP nano powder increased the bioactivity of this membrane. In terms of the drug release of ciprofloxacin and vitamin D3, 45% and 60% of drugs released within the first 24 h which in turn it shows the ability of the drugs controlled deliveration by the membrane. Accordingly, it could be concluded that this bilayer composite membrane with high bioactivity, high hydrophilicity, suitable mechanical properties, suitable morphology, and appropriate porosity has the ideal conditions for increased bone growth as well as proliferation and treatment the periodontal disease.
“…These results indicated that the modest sonication treatment (200 W, 5 min) could promote the interaction between maltodextrin and betalains, thereby limiting the vibration of the characteristic functional groups of maltodextrin, especially the groups of –OH and C-O-C that have the ability to form hydrogen bonds. Eslami, et al [37] also reported that the optimal ultrasound treatment (200 W, 13.7 min) could promote the interactions between alginate-chitosan and the component (Vitamin D 3 ), such as hydrogen bonds or electrostatic forces, and increase the microencapsulation efficiency (92.86%) and loading capacity (30.1%) of vitamin D 3 . Fig.…”
“…This can be achieved by ensuring that the pore size remains smaller that the size of the lipid‐based nanoparticles, and/or there is a strong attractive interaction between the polymer network and the lipid‐based nanoparticles. Several researchers have already used shown that vitamin D can be successfully encapsulated within hydrogels (Demisli et al., 2020; Eslami et al., 2018). One of the main drawbacks of this approach is that it is often challenging to produce large quantities of hydrogel particles on an industrial scale.…”
Over the past few decades, vitamin D deficiency has been recognized as a serious global public health challenge. The World Health Organization has recommended fortification of foods with vitamin D, but this is often challenging because of its low water solubility, poor chemical stability, and low bioavailability. Studies have shown that these challenges can be overcome by encapsulating vitamin D within well‐designed delivery systems containing nanoscale or microscale particles. The characteristics of these particles, such as their composition, size, structure, interfacial properties, and charge, can be controlled to attain desired functionality for specific applications. Recently, there has been great interest in the design, production, and application of vitamin‐D loaded delivery systems. Many of the delivery systems reported in the literature are unsuitable for widespread application due to the complexity and high costs of the processing operations required to fabricate them, or because they are incompatible with food matrices. In this article, the concept of “fortification by design” is introduced, which involves a systematic approach to the design, production, and testing of colloidal delivery systems for the encapsulation and fortification of oil‐soluble vitamins, using vitamin D as a model. Initially, the challenges associated with the incorporation of vitamin D into foods and beverages are reviewed. The fortification by design concept is then described, which involves several steps: (i) selection of appropriate vitamin D form; (ii) selection of appropriate food matrix; (iii) identification of appropriate delivery system; (iv) identification of appropriate production method; (vii) establishment of appropriate testing procedures; and (viii) system optimization.
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