Development of hybrid multi-head, multi-material paste and ink extrusion type 3D printer for biomedical applications

Ravoor, Jishita; Elsen, S.Renold; Thangavel, Mahendran; Arumugam, Dhanabal; Karuppan, Deepan

doi:10.1080/21870764.2023.2247210

Cited by 1 publication

(3 citation statements)

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“…Moreover, it's noteworthy that the FCT strand stability isn't merely material-dependent. Aspects like the nozzle diameter and filament thickness play a pivotal role, as illustrated recently by Ravoor et al 18 . On the other hand, the nozzle dimensions and the applied pressure have a significant impact on cell survival, as recently shown in a study by Han et al They managed to establish an experimentally verified model to quantitatively describe the ratio of damaged cells 24 .…”

Section: Introductionmentioning

confidence: 93%

“…7b. Equations (18)(19)(20) are then employed to determine the elongation viscosity as a function of strain rate (Fig. 7c) for 3 and 4 w/v% alginate solutions.…”

Section: Practical Example: Alginate-based Bioinksmentioning

confidence: 99%

“…Another version involves the printing of a rectangular pore to determine material spreading, comparing the theoretical to the actual perimeter area within the pore. Since these tests are not typically recorded in a time-dependent manner, they seldom provide insights into the viscoelastic properties of the material 12,[15][16][17][18][19][20] . The Filament Collapse Test (FCT) utilizes a substrate with pillars spaced at varying gap lengths.…”

mentioning

confidence: 99%

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Advanced optical assessment and modeling of extrusion bioprinting

Lamberger,

Schubert,

Buechner

et al. 2024

Sci Rep

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In the context of tissue engineering, biofabrication techniques are employed to process cells in hydrogel-based matrices, known as bioinks, into complex 3D structures. The aim is the production of functional tissue models or even entire organs. The regenerative production of biological tissues adheres to a multitude of criteria that ultimately determine the maturation of a functional tissue. These criteria are of biological nature, such as the biomimetic spatial positioning of different cell types within a physiologically and mechanically suitable matrix, which enables tissue maturation. Furthermore, the processing, a combination of technical procedures and biological materials, has proven highly challenging since cells are sensitive to stress, for example from shear and tensile forces, which may affect their vitality. On the other hand, high resolutions are pursued to create optimal conditions for subsequent tissue maturation. From an analytical perspective, it is prudent to first investigate the printing behavior of bioinks before undertaking complex biological tests. According to our findings, conventional shear rheological tests are insufficient to fully characterize the printing behavior of a bioink. For this reason, we have developed optical methods that, complementarily to the already developed tests, allow for quantification of printing quality and further viscoelastic modeling of bioinks.

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Section: Introductionmentioning

confidence: 93%

“…7b. Equations (18)(19)(20) are then employed to determine the elongation viscosity as a function of strain rate (Fig. 7c) for 3 and 4 w/v% alginate solutions.…”

Section: Practical Example: Alginate-based Bioinksmentioning

confidence: 99%