Development of humanised mouse model for DC based immunotherapy

Abstract

Dendritic cells (DCs) are professional antigen presenting cells (APC) that orchestrate the immune response. These cells play a major role in inducing primary immune response by activating naïve CD8 + and CD4 + T cells. In mice, CD8 + DC is the major DC subset that excels in priming CD8 + T cells to become cytotoxic T cells (CTL), critical to induce anti-tumour and anti-viral immunity. Human peripheral blood, lymphoid and nonlymphoid organs contain 3 major DC subsets, plasmacytoid dendritic cells (pDCs), CD1c + and CD141 + myeloid DCs, each with distinct functional characteristics. Comparative transcriptome analysis enabled close alignment of human