DEVELOPMENT OF HOST RANGE MUTANTS THROUGH THE INTER-ACTION OF TWO CLOSELY RELATED TEMPERATE PHAGES IN CORYNEBACTERIUM DIPHTHERIAE

Abstract

Development of host range mutants of bacteriophage has been believed generally to be a result of the spontaneous mutation of original phage (Luria, 1945). Recently, however, it has been proposed (Hershey et al., 1954) that the host range mutants of T3 phage arose from interactions between phage and bacterial cell, possibly in the nature of genetic substitutions. Fukumi and Nojima (1957) proposed a unitary theory which explained the host range mutation and the host-controlled variation (Luria and Human, 1952; and Bertani and Weigle, 1953) on the basis of the cross-over between host and phage genes (Weigle and Dulbecco, 1953;