Development of high-voltage pulse generator with variable amplitude and duration

Upadhyay, J.; Sharma, Mrinalini; Ahuja, Aakash B.; Navathe, C. P.

doi:10.1063/1.4884883

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Another study modified the Marx structure by using a solid-state boosting front-end and H-bridge output stage to enable modification of pulse duration and polarity for microsecond pulses [43]. Another approach generated 100–3000 V, 100–200 μs pulses by modifying the biasing supply of the high voltage MOSFET based switch [44]. …”

Section: Introductionmentioning

confidence: 99%

“…Often, the approaches used for creating adjustable submicrosecond pulses are not easily adapted to generating longer pulses [44] and vice versa. Thus, this paper focuses on developing a novel modification of a Marx bank architecture for flexible selection of pulse parameters from nanoseconds to microseconds while also being able to apply electric pulses to low (buffer solution) and high (blood, platelet rich plasma—PRP) conductivity solutions without requiring an external matching resistor.…”

Section: Introductionmentioning

confidence: 99%

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Design, characterization and experimental validation of a compact, flexible pulsed power architecture for ex vivo platelet activation

et al. 2017

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Electric pulses can induce various changes in cell dynamics and properties depending upon pulse parameters; however, pulsed power generators for in vitro and ex vivo applications may have little to no flexibility in changing the pulse duration, rise- and fall-times, or pulse shape. We outline a compact pulsed power architecture that operates from hundreds of nanoseconds (with the potential for modification to tens of nanoseconds) to tens of microseconds by modifying a Marx topology via controlling switch sequences and voltages into each capacitor stage. We demonstrate that this device can deliver pulses to both low conductivity buffers, like standard pulsed power supplies used for electroporation, and higher conductivity solutions, such as blood and platelet rich plasma. We further test the effectiveness of this pulse generator for biomedical applications by successfully activating platelets ex vivo with 400 ns and 600 ns electric pulses. This novel bioelectrics platform may provide researchers with unprecedented flexibility to explore a wide range of pulse parameters that may induce phenomena ranging from intracellular to plasma membrane manipulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Design, characterization and experimental validation of a compact, flexible pulsed power architecture for ex vivo platelet activation

et al. 2017

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An overvoltage driver with inductive adder pulse for fast switching of series-connected MOSFETs module

et al. 2019

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A novel overvoltage driver is proposed to speed up the turn-on transition of series-connected MOSFETs module which serves as the main switch in high voltage pulse generator. In order to realize the overvoltage driver, a nanosecond pulse with the amplitude of hundreds of volts is superposed on a square driving signal by linear transformer driver scheme. The results show that, comparing to the commercial high current driver, the turn-on time of a 10kV MOSFETs module including ten devices with the proposed driving scheme can be shortened from ∼25ns to ∼7ns. The proposed overvoltage driver can be used to conveniently modulate the rise time and pulse width of high voltage nanosecond pulse generator constructed by MOSFETs. In addition, it is demonstrated that there is almost no influence of the overvoltage driver on the gate-source characteristics of device by analyzing the variation of C-f curves of input capacitances.

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Design and development of water-immersible two-channel high-voltage spike pulser for under-water inspection and gauging of pipes

Kumar

Patankar

2022

Review of Scientific Instruments

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A water-immersible two-channel high-voltage (HV) spike pulser has been designed, developed, and mounted inside the IP 67 (Ingress Protection 67) grade enclosure, and it is suitable for the ultrasonic Pipe Inspection and Gauging (PIG) system utilized in the petrochemical industry. Such a critical and strategic application requires a portable, miniaturized, and water-immersible water-tight pulser module, which resides inside the pipe carrying water or liquid petrochemicals. The developed spike pulser printed circuit board (PCB) generates a HV negative spike pulse up to −300 V and 100 ns half-amplitude pulse width, required for the energization of ultrasonic immersion transducers of 5–10 MHz frequency. The water-immersible pulser is mounted inside the water-tight IP 67 grade enclosure, and it is operated through an external DC power supply/lithium batteries. The evaluation of the module was carried out using a two-channel water-immersible HV spike pulser, in-house developed preamplifier, and inspection head supported by four sets of spring-loaded Teflon balls for centering, and the inspection head carries two ultrasonic immersion transducers placed 180° apart and a sample SS pipe with a length of 400 mm, Inner Diameter of 200 mm, and Wall Thickness of 9 mm. The two-channel pulser module was evaluated in water to measure the dimensions of the sample SS pipe. This two-channel water-immersible novel spike pulser has dedicated circuitry, and each channel is a standalone PCB and it operates through external LV and HV DC supplies. The module can be scaled up to 256 channels for dimension measurement and flaw detection of long length pipes. In the absence of any literature available on the water-immersible pulser for PIG systems, the present two-channel pulser module has been designed and developed, and the module was evaluated by gauging of the SS pipe from inside. This paper provides the details of the water-immersible HV spike pulser module suitable for the gauging of metallic pipes.

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Development of high-voltage pulse generator with variable amplitude and duration

Cited by 4 publications

References 6 publications

Design, characterization and experimental validation of a compact, flexible pulsed power architecture for ex vivo platelet activation

Design, characterization and experimental validation of a compact, flexible pulsed power architecture for ex vivo platelet activation

An overvoltage driver with inductive adder pulse for fast switching of series-connected MOSFETs module

Design and development of water-immersible two-channel high-voltage spike pulser for under-water inspection and gauging of pipes

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