2021
DOI: 10.1128/aac.02522-20
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Development of High-Level Daptomycin Resistance in Abiotrophia and Granulicatella Species Isolates from Patients with Infective Endocarditis

Abstract: Abiotrophia and Granulicatella species are fastidious organisms, representing around 1%–3% of infective endocarditis (IE). Little is known about the optimal antibiotic treatment of these species, and daptomycin has been suggested as a therapeutic option. We describe the antimicrobial profile in Abiotrophia and Granulicatella IE isolates, investigate high-level daptomycin resistance (HLDR) development and evaluate daptomycin act… Show more

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Cited by 3 publications
(2 citation statements)
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“…After being incubated with inhibitory concentrations of DAP, all strains rapidly increased the baseline MIC of daptomycin and showed resistance with either a DNS or HLDR profile. Even combination therapy did not prevent the development of DAP resistance with AMP (2/3 strains), CN (2/3 strains), CRO (2/3 strains), or ceftaroline (2/3 strains), thus rising further doubts about the optimal antibiotic treatment for these species [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…After being incubated with inhibitory concentrations of DAP, all strains rapidly increased the baseline MIC of daptomycin and showed resistance with either a DNS or HLDR profile. Even combination therapy did not prevent the development of DAP resistance with AMP (2/3 strains), CN (2/3 strains), CRO (2/3 strains), or ceftaroline (2/3 strains), thus rising further doubts about the optimal antibiotic treatment for these species [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…Among the few reported cases of infective endocarditis due to A. defectiva, the majority underwent valvular replacement despite adequate antibiotic therapy (15)(16)(17). A. defectiva strains that are highly resistant to Penicillin G or multidrug-resistant have also been reported (18), and patients with penicillin-resistant A. defectiva IE may experience worse outcomes with a higher rate of recurrence in comparison to patients with IE caused by other viridans group streptococci. Blood cultures do not always predict the appropriate antibiotic treatment for this pathogen as it is difficult to culture on standard blood agar media without supplementation, which may lead to false-negative results.…”
Section: Discussionmentioning
confidence: 99%