Development of height and weight in children with diabetes mellitus: Report on two prospective multicentre studies, one cross-sectional, one longitudinal

Thon, A.; Heinze, E.; Feilen, K.; Holl, Reinhard W.; Schmidt, H; Koletzko, Sibylle; Wendel, U.; Nothjunge, J

doi:10.1007/bf02072224

Cited by 72 publications

(50 citation statements)

References 28 publications

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“…Similar data have been reported by other authors (62). It has also been shown that height at diagnosis in a group of 89 children with duration of diabetes of more than 3 years and a mean age of 8.9^2.2 years was not different compared with 102 healthy control children (63). In a longitudinal study, it has been shown that height at diagnosis in a total of 436 children with diabetes was significantly above the reference population.…”

Section: Growth and Developmentsupporting

confidence: 87%

Growth, growth factors and diabetes

Chiarelli

Giannini²,

Mohn³

2004

European Journal of Endocrinology

107

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Type 1 diabetes mellitus (T1DM) and other chronic diseases in children are well known to adversely affect linear growth and pubertal development. In the years immediately following the introduction of insulin therapy, short stature was consistently reported in children with T1DM. However, over the past 50 years significant improvement in the prognosis for growth and final height in children with diabetes has been achieved. Although pre-pubertal and post-pubertal growth are important phases in growth, puberty and its related hormonal changes represent a critical phase for growth gain and final height particularly in patients with T1DM. Growth impairment reported in diabetic patients is dependent on abnormalities in physiological bone growth and corresponds to abnormalities of the growth hormone -insulin-like growth-I (GH -IGF-I) axis. These alterations seem to be related to appropriate insulin levels and thereby to glycaemic control as judged by haemoglobin levels. Modern diabetes care, particularly intensified insulin regimens, might improve metabolic control in patients with T1DM, therefore preventing abnormalities of the GH -IGF-I axis and leading to normal growth and final height similar to that of their unaffected peers. European Journal of Endocrinology 151 U109-U117

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Section: Growth and Developmentsupporting

confidence: 87%

Growth, growth factors and diabetes

Chiarelli

Giannini²,

Mohn³

2004

European Journal of Endocrinology

107

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“…Several studies have suggested that leptin also influences sexual progression through puberty (6)(7)(8). Impaired growth and pubertal delay have been observed in children with diabetes (9)(10)(11). Also, these children tend to develop obesity, even if they are treated with modern insulin therapy.…”

Section: Introductionmentioning

confidence: 99%

Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor

Kratzsch

Knerr²,

Galler³

et al. 2006

eur j endocrinol

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Objective: Type 1 diabetes mellitus (T1DM) leads to increased serum levels of the soluble leptin receptor (sOB-R) by an as yet unknown cellular mechanism. The aim of our study was to investigate potential metabolic factors that may be associated with the induction of the sOB-R release from its membrane receptor. Materials and methods: Twenty-five children (aged between 1.5 and 17.0 years) were studied at the onset of T1DM. Blood samples were collected before (nZ25), during the first 18 h (meanGS.D. 11.1G 4.3 h, nZ16) and 92 h (47.5G22.5 h; nZ14) after beginning insulin therapy. Serum sOB-R and leptin levels were determined by in-house immunoassays. Results: The sOBR-level and the molar sOB-R/leptin ratio were significantly higher before than after starting insulin treatment (P!0.05). In contrast, leptin levels were significantly lower (P!0.05) before insulin therapy. The correlation between sOB-R and blood glucose (rZ0.49; P!0.05), as well as sOB-R with parameters of ketoacidosis, such as pH (rZK0.72), base excess (rZK0.70), and bicarbonate (rZK0.69) (P!0.0001) at diagnosis of T1DM remained significant during the first 18 h of insulin treatment. Multiple regression analysis revealed that base excess predicted 41.0% (P!0.001), age 16.4% (P!0.05), and height SDS 13.9% (P!0.01) of the sOB-R variance. Conclusions: Metabolic decompensation in children with new onset T1DM is associated with dramatic changes of the leptin axis; serum levels of sOB-R are elevated and of leptin are reduced. The molar excess of sOB-R over leptin (median 11.3) in this condition may contribute to leptin insensitivity. Upregulation of the soluble leptin receptor appears to be a basic mechanism to compensate for intracellular substrate deficiency and energy-deprivation state.European Journal of Endocrinology 155 609-614

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“…The question whether diabetes, well treated with conventional means, still compromises the growth of diabetic children, remains controversial. Many studies claim that longitudinal growth is impaired in diabetic children (1)(2)(3)(4)(5)(6)(7). Some investigators have observed catch-up growth in poorly controlled diabetic children after a better degree of control had been achieved (8)(9)(10).…”

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confidence: 99%