Development of hearing in neonatal rats: Air and bone conducted ABR thresholds

Geal-Dor, Miriam; Freeman, Sharon; Li, G.; Sohmer, Haim

doi:10.1016/0378-5955(93)90113-f

Cited by 192 publications

(163 citation statements)

References 23 publications

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“…Auditory cortical IRFs were far more heterogeneous and irregular than those described for the auditory nerve, which shows the opposite trend of bandwidth changes with age (25). Moreover, the auditory nerve and brainstem mature very early in the course of development compared with what we observed in the cortex (25)(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 41%

Development of spectral and temporal response selectivity in the auditory cortex

Chang

Bao²,

Imaizumi³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

146

160

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The mechanisms by which hearing selectivity is elaborated and refined in early development are very incompletely determined. In this study, we documented contributions of progressively maturing inhibitory influences on the refinement of spectral and temporal response properties in the primary auditory cortex. Inhibitory receptive fields (IRFs) of infant rat auditory cortical neurons were spectrally far broader and had extended over far longer duration than did those of adults. The selective refinement of IRFs was delayed relative to that of excitatory receptive fields by an Ϸ2-week period that corresponded to the critical period for plasticity. Local application of a GABA A receptor antagonist revealed that intracortical inhibition contributes to this progressive receptive field maturation for response selectivity in frequency. Conversely, it had no effect on the duration of IRFs or successive-signal cortical response recovery times. The importance of exposure to patterned acoustic inputs was suggested when both spectral and temporal IRF maturation were disrupted in rat pups reared in continuous, moderate-intensity noise. They were subsequently renormalized when animals were returned to standard housing conditions as adults.

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Section: Discussionmentioning

confidence: 41%

Development of spectral and temporal response selectivity in the auditory cortex

Chang

Bao²,

Imaizumi³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

146

160

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“…It was notable that immunolabeling of all five P2Y receptors emerged in the late embryonic period. Subsequently, rapid divergence of expression by these receptors corresponded to the period of cellular differentiation from P0 to the onset of hearing (approximately P12, [30]). Beyond the second postnatal week to the adult, the P2Y receptor expression profile exhibited only minor changes within the cochlear tissues.…”

Section: Resultsmentioning

confidence: 99%

Differential expression of P2Y receptors in the rat cochlea during development

Huang

Thorne

Vlajkovic

et al. 2010

Purinergic Signalling

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Purinergic signaling has broad physiological significance to the hearing organ, involving signal transduction via ionotropic P2X receptors and metabotropic G-protein-coupled P2Y and P1 (adenosine), alongside conversion of nucleotides and nucleosides by ectonucleotidases and ecto-nucleoside diphosphokinase. In addition, ATP release is modulated by acoustic overstimulation or stress and involves feedback regulation. Many of these principal elements of the purinergic signaling complex have been well characterized in the cochlea, while the characterization of P2Y receptor expression is emerging. The present study used immunohistochemistry to evaluate the expression of five P2Y receptors, P2Y 1 , P2Y 2 , P2Y 4 , P2Y 6 , and P2Y 12 , during development of the rat cochlea. Commencing in the late embryonic period, the P2Y receptors studied were found in the cells lining the cochlear partition, associated with establishment of the electrochemical environment which provides the driving force for sound transduction. In addition, early postnatal P2Y 2 and P2Y 4 protein expression in the greater epithelial ridge, part of the developing hearing organ, supports the view that initiation and regulation of spontaneous activity in the hair cells prior to hearing onset is mediated by purinergic signaling. Sub-cellular compartmentalization of P2Y receptor expression in sensory hair cells, and diversity of receptor expression in the spiral ganglion neurons and their satellite cells, indicates roles for P2Y receptormediated Ca 2+ -signaling in sound transduction and auditory neuron excitability. Overall, the dynamics of P2Y receptor expression during development of the cochlea complement the other elements of the purinergic signaling complex and reinforce the significance of extracellular nucleotide and nucleoside signaling to hearing.

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“…Areas that contain TIP39 neurons are involved in sexual (Coolen et al, 2004;Holstege et al, 2003) and maternal functions (Li et al, 1999;Lin et al, 1998), suggesting that TIP39 may be as well. Nociception (Hamm and Knisely, 1988), hearing (Geal-Dor et al, 1993), endocrine functions (Eden, 1979;Moguilevsky and Wuttke, 2001) and clearly sexual functions (Lamming, 1994), undergo profound postnatal development in the rat. Bearing in mind that TIP39's homologue, PTHrP, has well-established effects on the development of many tissues (Kronenberg et al, 1998) and that TIP39 can affect the proliferation of some cell types in vitro (Misiano et al, 2003), the transient expression of TIP39 during postnatal development suggests that this peptide may be involved in developmental aspects of the above mentioned brain functions.…”

Section: Potential Functions Of Tip39mentioning

confidence: 99%

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

Dobolyi

Wang

Irwin

et al. 2006

J of Comparative Neurology

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Tuberoinfundibular peptide of 39 residues (TIP39) is a selective agonist of the parathyroid hormone 2 (PTH2) receptor. The topographical distributions of TIP39 and the PTH2 receptor in the brain, described in young male rats, suggested that TIP39 has limbic and endocrine functions. In the present study, we investigated the expression of TIP39 and the PTH2 receptor in male and female rat brain during postnatal development by means of in situ hybridization histochemistry, quantitative RT-PCR and immunocytochemistry. TIP39's distribution and expression levels are similar in young female and male brains. TIP39 mRNA levels peak at postnatal day 14 and subsequently decline both in the subparafascicular area and the medial paralemniscal nucleus, the two major sites where TIP39 is synthesized. A greater developmental decrease in TIP39 expression in males leads to greater levels in older females than older males. The decrease is partially reversed by pre-pubertal but not post-pubertal gonadectomy. TIP39 peptide levels in cell bodies change in parallel with mRNA levels, while TIP39 appears and disappears somewhat later in nerve fibers. In addition, TIP39 peptide levels are also sexually dimorphic in older rats. In contrast, PTH2 receptor expression in the brain does not decrease during puberty and is not sexually dimorphic even in old animals. The appearance of TIP39 during early, and decline during late, postnatal development together with the gender dependent levels in mature animals suggest that TIP39 may play a role in sexual maturation or gender specific functions. Indexing termstuberoinfundibular peptide of 39 residues; parathyroid hormone 2 receptor; TIP39 and PTH2 receptor in situ hybridization and immunocytochemistry and quantitative

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Development of hearing in neonatal rats: Air and bone conducted ABR thresholds

Cited by 192 publications

References 23 publications

Development of spectral and temporal response selectivity in the auditory cortex

Development of spectral and temporal response selectivity in the auditory cortex

Differential expression of P2Y receptors in the rat cochlea during development

Postnatal development and gender‐dependent expression of TIP39 in the rat brain

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