Development of hamster circadian rhythms: Role of the maternal suprachiasmatic nucleus

Davis, Fred C.; Gorski, Roger A.

doi:10.1007/bf01342635

Cited by 115 publications

(68 citation statements)

References 24 publications

(30 reference statements)

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“…1. Previous studies have suggested that the fetus in the uterus uses maternal signals to adapt the fetal biological clock to the maternal environment (Reppert and Schwartz 1983;Davis and Gorski 1988;Parraguez et al 1996;Kennaway 2002;Ohta et al 2002Ohta et al , 2003Ohta et al , 2008Sládek et al 2004;Li and Davis 2005;Saxena et al 2007). These signals are considered to be a variety of nonphotic stimuli including circadian fluctuations in hormonal and nutritional signals from the mother, placental filtering of those signals, and uterine motility (Serón-Ferré et al 2007).…”

Section: Discussionmentioning

confidence: 99%

The Uterus Sustains Stable Biological Clock during Pregnancy

Akiyama

Ohta

Watanabe

et al. 2010

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

The Uterus Sustains Stable Biological Clock during Pregnancy

Akiyama

Ohta

Watanabe

et al. 2010

Tohoku J. Exp. Med.

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“…ablated suprachiasmatic nuclei and subsequently raised in constant dim light are rhythmic with scattered phases (29). However, earlier studies of the ontogeny of Drosophila rhythms have been inconclusive (25,30,31).…”

Section: Discussionmentioning

confidence: 99%

Ontogeny of a biological clock in Drosophila melanogaster.

Sehgal

Price

Young

1992

Proc. Natl. Acad. Sci. U.S.A.

116

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Drosophila melanogaster born and reared in constant darkness exhibit circadian locomotor activity rhythms as adults. However, the rhythms of the individual flies composing these populations are not synchronized with one another. This lack of synchrony is evident in populations of flies commencing development at the same time, indicating that a biological clock controlling circadian rhythmicity in Drosophila begins to function without a requirement for light and without a developmentally imparted phase. It is possible to synchronize the phases of rhythms produced by dark-reared flies with light treatments ending as early as the developmental transition from embryo to first-instar larva: Light treatments occurring at developmental times preceding hatching of the first-instar larva fail to synchronize adult locomotor activity rhythms, while treatments ending at completion of larval hatching entrain these rhythms. The synchronized rhythmic behavior of adult flies receiving such light treatments suggests that a clock controlling circadian rhythms may function continuously from the time of larval hatching to adulthood.

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“…Studies in other species indicate that entrainment during the fetal and early postnatal period is produced by cues derived from the mother (reviewed in Reppert et al, 1989;Takahashi et al, 1989). For example, lesioning of the maternal SCN in the Syrian hamster or rat early in gestation produces litters with asynchronous rhythms (Davis and Gorski, 1988;Reppert and Schwartz, 1986b). Therefore, synchrony shown by the litters in the current study is probably a result of maternal entrainment and not produced by an unknown environmental zeitgeber.…”

Section: Maternal Entrainment In the Siberian Hamstermentioning

confidence: 63%

“…In fact, the potential for entrainment during the postnatal period clearly does exist in the Syrian hamster, as revealed by the synchronizing effects of timed melatonin treatments during the first postnatal week (Grosse et al, 1996). One likely explanation for this species difference may relate to litter size, which is generally smaller for Siberian hamsters (typically 4-5) (Ebling, 1994) than for Syrian hamsters (typically 6-10) (Davis and Gorski, 1988;Davis and Mannion, 1988;Grosse et al, 1996). Honma and colleagues (1987) revealed a litter size effect on the ability of a foster mother to re-entrain the phases of rat pups, in that a greater proportion of pups were synchronized to the phase of the foster mother when the litter size was small than when it was large.…”

Section: Maternal Entrainment During the Preand Postnatal Periodsmentioning

confidence: 99%

“…Behavioral studies in the Syrian hamster examined the effect of weaning on pup phases by weaning animals from the same litter at two different times of the day, approximately 12 h apart (Davis and Gorski, 1985Viswanathan and Davis, 1992;Grosse et al, 1996). This revealed either a small effect (Davis andGorski, 1985, 1986) or no effect (Davis and Gorski, 1988;Viswanathan and Davis, 1992;Grosse et al, 1996), depending on the individual study.…”

Section: Other Effects Of the Experimental Paradigms On The Developinmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Entrainment of the Developing Circadian System in the Siberian Hamster (Phodopus sungorus)

Duffield¹,

Ebling

1998

J Biol Rhythms

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The aim of these studies was to investigate maternal entrainment of developing circadian locomotor activity rhythms in the Siberian hamster. In Experiment 1, mothers were transferred from a 16:8 LD cycle into constant dim red light (DD) from the day of parturition, and wheel-running activity of the mother and pups was individually monitored from the time of weaning. The phases of the individual pups' rhythms were found to be synchronized both to the phase of the mother and to the phase of lights off (ZT 12) of the photo cycle that the mother was exposed to until the day of parturition. To investigate whether this synchrony might reflect direct effects of light acting upon the fetal circadian system in late gestation, the experiment was repeated but with mothers placed into DD early in pregnancy (≤ day 7 of gestation). The results were similar to the first study, suggesting that the mother rather than the photo cycle during the latter part of gestation entrains the developing circadian system. The third experiment investigated whether this entrainment occurred during the postnatal period. Breeding pairs were maintained on alternative light-dark cycles, LD and DL, that were 12 h out of phase. Litters born to mothers on one light-dark cycle were exchanged on the day of birth with foster mothers from the reversed light-dark cycle, then raised in DD. Control litters exchanged between mothers from the same light-dark cycle had similar litter synchrony as shown by nonfostered litters of Experiment 1. However, pups cross-fostered with mothers on reversed LD cycles showed a very different distribution of pup phases. Pups were not synchronized to their natural mother but to their foster mother. Moreover, pups were more scattered over the 24-h period and were found to be significantly synchronized to the phase of the reversed LD cycle. These results demonstrate the occurrence of postnatal entrainment in the Siberian hamster. The increased scatter produced by the cross-fostering paradigm results from some litters being completely entrained to the phase of the foster mother, some with an intermediate distribution between the phases of the natural and foster mothers, and a minority being associated with the phase of the natural mother. These results suggest that Siberian hamster pups are initially synchronized either prenatally or at birth but that the mother continues to provide entrainment signals during the postnatal period.

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Development of hamster circadian rhythms: Role of the maternal suprachiasmatic nucleus

Cited by 115 publications

References 24 publications

The Uterus Sustains Stable Biological Clock during Pregnancy

The Uterus Sustains Stable Biological Clock during Pregnancy

Ontogeny of a biological clock in Drosophila melanogaster.

Maternal Entrainment of the Developing Circadian System in the Siberian Hamster (Phodopus sungorus)

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