Development of GSK's acid and base selection guides

Abstract

Common acids and bases were ranked based on their EHS profile and the impact of their use in typical reactions.

Green Chemistry in Higher Education: State of the Art, Challenges, and Future Trends

“…[41] The first, crucial step in the application of anyk ind of metric is balancing chemical equations. To select more benign reagents, [45] solvents, [46,47] and auxiliary substances, [48] selection systems should be discussed. [42] The application of as ynthesis treed iagram is an easy way to identify all substrates, intermediates, and reaction steps in mass efficiency assessment.…”

“…For propere nergy consumption assessment, it is obligatory to incorporate thermodynamics into curricula. To select more benign reagents, [45] solvents, [46,47] and auxiliary substances, [48] selection systems should be discussed. They are basic tools in searching for greener alternatives that provide ag reat overview of alternatives and, most importantly,a re ag ood startingp oint for discussions on criteria that reflect the greenness of chemicals.…”

Brønsted Acid Catalyzed Tandem Defunctionalization of Biorenewable Ferulic acid and Derivates into Bio‐Catechol

“…HCl was chosen for further optimization, given its abundance and low cost. Moreover, it is recommended based on a green acid selection guide . Optimization revealed the yield of 2 was increased by decreasing the concentration of 1 a (Entries 7, 8) and increasing HCl loading (Entries 7, 12), with, respectively 0.13 m and 50 mol % as optimal parameters.…”

Bio‐Based Chiral Amines via Aza‐Michael Additions to (–)‐Levoglucosenone Under Aqueous Conditions

“…[11] Moreover, the resulting aza-Michael products folds 5 as a single diastereomer (Scheme 1, C). [22] We were specifically interested in developing an aza-Michael addition to LGO that was wide in scope and free from organic solvents and toxic bases. Diethyl ether, acetonitrile and chloroform perform badly in environmental and safety assessment rankings.…”

“…Although these metal hydroxides are considered to be green bases, potassium and sodium hydroxide can cause severe burns, [22] so it is preferable to avoid their use if possible. Lithium, sodium and potassium hydroxide all gave near identical yields of 2a (entries 5-7), but with inferior results to potassium carbonate.…”