Development of Gold-Coated Magnetic Nanoparticles as a Potential MRI Contrast Agent

Montazerabadi, Alireza; Oghabian, Mohammad Ali; Irajirad, Rasoul; Muhammadnejad, Samad; Ahmadvand, Davoud; Delavari, Hamid; Mahdavi, Seied Rabi

doi:10.1142/s1793292015500484

Cited by 40 publications

(25 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modification of their surface enables SPIONs to be used, e.g., as contrast agents in magnetic resonance imaging [ 19 , 20 ] or as drug delivery systems for the magnetic drug targeting of tumors and vascular injuries [ 21 , 22 , 23 ]. By combining the highly magnetic properties of SPIONs with an easy-to-functionalize gold surface, a fundamental hybrid carrier system (Au-SPIONs) can be generated [ 24 , 25 , 26 , 27 ], on which molecules designed for various medical applications can be attached. Hence, applications such as photothermal or drug delivery therapy may not be limited by the unspecific accumulation of the particles in the tissue as Au-SPIONs can be magnetically guided for a control of their biodistribution and localization of their efficacy in the targeted tissue.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

et al. 2020

View full text Add to dashboard Cite

Surface-functionalized gold-coated superparamagnetic iron oxide nanoparticles (Au-SPIONs) may be a useful tool in various biomedical applications. To obtain Au-SPIONs, gold salt was precipitated onto citrate-stabilized SPIONs (Cit-SPIONs) using a simple, aqueous one-pot technique inspired by the Turkevich method of gold nanoparticle synthesis. By the further stabilization of the Au-SPION surface with additional citrate (Cit-Au-SPIONs), controllable and reproducible Z-averages enhanced long-term dispersion stability and moderate dispersion pH values were achieved. The citrate concentration of the reaction solution and the gold/iron ratio was found to have a major influence on the particle characteristics. While the gold-coating reduced the saturation magnetization to 40.7% in comparison to pure Cit-SPIONs, the superparamagnetic behavior of Cit-Au-SPIONs was maintained. The formation of nanosized gold on the SPION surface was confirmed by X-ray diffraction measurements. Cit-Au-SPION concentrations of up to 100 µg Fe/mL for 48 h had no cytotoxic effect on Jurkat cells. At a particle concentration of 100 µg Fe/mL, Jurkat cells were found to take up Cit-Au-SPIONs after 24 h of incubation. A significantly higher attachment of thiol-containing L-cysteine to the particle surface was observed for Cit-Au-SPIONs (53%) in comparison to pure Cit-SPIONs (7%).

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Asymmetric and symmetric stretching vibrations of the CH 2 of mPEG were observed at 2916 cm −1 and 2916 cm −1 , respectively. Moreover, a carboxylate bond (‐COO) was observed at 1120 cm −1 , which demonstrates the absorption of mPEG with NH 2 group …”

Section: Resultsmentioning

confidence: 99%

A study on the Concentration‐dependent Relaxometric Transition in Manganese Oxide Nanocolloid as MRI Contrast Agent

et al. 2019

View full text Add to dashboard Cite

A green precipitation method has been used for the synthesis of ultra-small APTMS-mPEG conjugated Mn 3 O 4 nanoparticles. Spherical cores in the uniform size of 4 � 1 nm were characterized by HRTEM. Zeta potential of À 45 mV and the invariant turbidimetry results during the time, confirmed super-stability of the colloids. MRI relaxometry by 1.5 T scanner represented two values of r 1 = 8.23 s À 1 mM À 1 and r 1 = 7.3 s À 1 mM À 1 for diluted and concentrated samples. The r 2 /r 1 ratio was also decreased from 11.86 to 6.9 by dilution of colloids. Particle aggregation and motional narrowing phenomena led to a dual T 1 /T 2 contrast agent in the Mn ion concentrations of more than 0.2 mM. The optimum concentration of Mn ion for maximum dual signal intensity was estimated about 0.4 mM which is two times less than commercial Gd-DTPA. Cytotoxicity was examined through MTT assay and respectively, showed high cell viability at 48 h incubation. Overall, a potential dual T 1 /T 2 contrast agent was developed for early-stage detection.

show abstract

“…The use of inorganic compounds such as gold, silver, silica gel and carbon as surfactants not only provides good stability to the nanoparticles but also allows functionalizing their surface by grafting certain biological ligands. Covering of magnetic nanoparticles with gold seems to be ideal because of its low reactivity; however, coating the magnetic nanoparticles directly with gold is very difficult due to the different nature of the two surfaces [86][87][88][89]. The silica gel is the most widely used compound in the preparation of functionalized iron oxide nanoparticles surface, because it has several advantages: excellent biocompatibility, hydrophilicity, the feasibility of integrating other functional groups on the surface due to terminal silanol groups that can react with different coupling agents, provides good stabilization of the magnetic iron oxide nanoparticles in the solution, prevents the interaction between the nanoparticles thus preventing the agglomeration of the particles over time and ensures better encapsulation [90].…”

Section: Ianoş Et Al Reported a New Combustion Synthesis Technique Fmentioning

confidence: 99%

Preclinical Aspects on Magnetic Iron Oxide Nanoparticles and Their Interventions as Anticancer Agents: Enucleation, Apoptosis and Other Mechanism

Moacă¹,

Coricovac²,

MarinelaSoica³

et al. 2018

Iron Ores and Iron Oxide Materials

View full text Add to dashboard Cite

The broad area of magnetic iron oxide nanoparticle (M-IONP) applications and their exclusive physico-chemical characteristics (superparamagnetic properties per se, solubility and stability in aqueous solutions, and high bioavailability in vivo) make these nanoparticles suitable candidates for biomedical uses. The most employed magnetic iron oxides in the biomedical field are magnetite and maghemite. Cancer represents a complex pathology that implies multiple mechanisms and signaling pathways, this complexity being responsible for the increased resistance to therapy and the lack of an effective curative treatment. A potential useful alternative was considered to be the use of magnetic iron nanoparticles. The M-IONPs proved to be effective as contrast agents in magnetic resonance imaging, as drug delivery carriers for different therapeutic agents, in magnetic cell separation assays, and are suitable to be engineered in terms of size, targeted delivery and substance release. Moreover, their in vivo administration was considered safe, and recent studies indicated their efficiency as anticancer agents. This chapter aims to furnish an overview regarding the physico-chemical properties of M-IONPs (mainly magnetite, maghemite and hematite), the synthesis methods and their in vitro biological impact on healthy and cancer cell lines, by describing their potential mechanism of action-enucleation, apoptosis or other mechanisms.

show abstract

Development of Gold-Coated Magnetic Nanoparticles as a Potential MRI Contrast Agent

Cited by 40 publications

References 33 publications

Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

A study on the Concentration‐dependent Relaxometric Transition in Manganese Oxide Nanocolloid as MRI Contrast Agent

Preclinical Aspects on Magnetic Iron Oxide Nanoparticles and Their Interventions as Anticancer Agents: Enucleation, Apoptosis and Other Mechanism

Contact Info

Product

Resources

About