Development of gliomas: potential role of asymmetrical cell division of neural stem cells

Berger, François; Pelletier, Laurent; Tropel, Philippe; Wion, Didier

doi:10.1016/s1470-2045(04)01531-1

Cited by 65 publications

(46 citation statements)

References 41 publications

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“…[2][3][4] It has been hypothesized that glioblastoma CSCs may arise from the malignant transformation of neural stem cells (SCs) that are resident in the subventricular zone and that the migration of these cells may lead to the development of glioma in different areas of the brain. 5 Although tumorigenicity may be not confined entirely to the CD133-positive cell fraction of glioblastoma, [6][7][8][9] growing data demonstrate that CD133 expression is related to an adverse prognosis [10][11][12][13][14] and that the CD133-expressing glioblastoma cells contribute to radiochemoresistance and tumor aggressiveness. [15][16][17][18][19] For example, Liu and colleagues demonstrated a positive selection for CD133-positive tumor cells in patients with glioblastoma after chemotherapy.…”

mentioning

confidence: 99%

Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis

Pallini

Ricci–Vitiani²,

Montano

et al. 2010

Cancer

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BACKGROUND: Experimental data suggest that glioblastoma cells expressing the stem cell marker CD133 play a major role in radiochemoresistance and tumor aggressiveness. To date, however, there is no clinical evidence that the fraction of CD133-positive cells in glioblastoma that recurs after radiochemotherapy may be relevant for prognosis. METHODS: The authors used immunohistochemistry to assess CD133 expression in 37 paired glioblastoma samples, including 1 primary tumor sample and 1 recurrent tumor sample, after patients received adjuvant radiochemotherapy. To assess the actual composition of the CD133-positive glioblastoma cell population, fluorescence-associated cell sorting (FACS) analysis was used to sort CD133-positive/CD45-negative cells that were assayed for tumor-specific chromosomal aberrations using interphase fluorescence in situ hybridization. To rule out endothelial precursor cells, CD133-positive fractions also were assayed with anti-CD34 by FACS. RESULTS: In recurrent glioblastomas, the percentage of CD133-positive cells was increased by 4.6-fold compared with the percentage in primary glioblastomas, although, in some tumors, it increased up to 10-fold and 20-fold. Unexpectedly, the increase in CD133 expression was associated significantly with longer survival after tumor recurrence. An analysis of tumor-specific chromosomal aberrations and in vivo studies revealed that the CD133-positive cell compartment of recurrent glioblastoma was composed of both cancer stem cells and nontumor neural stem cells. The latter cells represented from 20% to 60% of the CD133-positive cell population, and their relative percentage favorably affected the survival of patients with recurrent glioblastoma. Endothelial CD133-positive/CD34-positive precursors did not contribute to the CD133-positive cell population. CONCLUSIONS: The authors hypothesized that, similar to the phenomenon described in glioblastoma models, neural stem/progenitor cells that are recruited by the tumor from surrounding brain may exert an antitumorigenic effect. Cancer 2011;117:162-74.

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mentioning

confidence: 99%

Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis

Pallini

Ricci–Vitiani²,

Montano

et al. 2010

Cancer

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“…Given their ability to proliferate, self-renew, and migrate, these cells have also the potential to undergo neoplastic transformation (Recht et al, 2003), and a large body of evidence supports this concept, although the identity of the transformed cells is not well defined (Rao, 1999;Holland, 2000;Berger et al, 2004;Jang et al, 2004). Four distinct cell types reside in the adult SVZ (Doetsch et al, 1997(Doetsch et al, , 1999a.…”

Section: Introductionmentioning

confidence: 99%

Loss ofp53Induces Changes in the Behavior of Subventricular Zone Cells: Implication for the Genesis of Glial Tumors

Gil-Perotín¹,

Marin-Husstege²,

Li³

et al. 2006

J. Neurosci.

196

182

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The role of multipotential progenitors and neural stem cells in the adult subventricular zone (SVZ) as cell-of-origin of glioblastoma has been suggested by studies on human tumors and transgenic mice. However, it is still unknown whether glial tumors are generated by all of the heterogeneous SVZ cell types or only by specific subpopulations of cells. It has been proposed that transformation could result from lack of apoptosis and increased self-renewal, but the definition of the properties leading to neoplastic transformation of SVZ cells are still elusive. This studyaddressesthesequestionsinmicecarryingthedeletionofp53,atumor-suppressorgeneexpressedintheSVZ.Weshowherethat,although loss of p53 by itself is not sufficient for tumor formation, it provides a proliferative advantage to the slow-and fast-proliferating subventricular zone (SVZ) populations associated with their rapid differentiation. This results in areas of increased cell density that are distributed along the walls of the lateral ventricles and often associated with increased p53-independent apoptosis. Transformation occurs when loss of p53 is associated with a mutagenic stimulus and is characterized by dramatic changes in the properties of the quiescent adult SVZ cells, including enhanced self-renewal, recruitment to the fast-proliferating compartment, and impaired differentiation.Together, these findings provide a cellular mechanism for how the slow-proliferating SVZ cells can give rise to glial tumors in the adult brain.

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“…In their work the authors suggested that cancer stem cells reside in their niche, which clinically can be a silent area, while the cancer progenitor cells would migrate away from the SVZ and give rise to a tumour. 21 This migratory capability of stem cells is further supported by several animal studies. 6,7 Also in humans SVZ stem cells have been shown to be capable of producing neuroblasts that can migrate away from the SVZ to areas of injured brain tissue.…”

Section: Discussionmentioning

confidence: 72%

“…20 Contrary to this, Berger and colleagues proposed, cells can, besides normal mitosis, undergo an asymmetrical division. 21 In stem cells this means that the mother stem cell divides into one self-renewing stem cell and one progenitor cell which can further differentiate. In their work the authors suggested that cancer stem cells reside in their niche, which clinically can be a silent area, while the cancer progenitor cells would migrate away from the SVZ and give rise to a tumour.…”

Section: Discussionmentioning

confidence: 99%

Subventricular Zone Involvement Characterized by Diffusion Tensor Imaging in Glioblastoma

et al. 2017

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Development of gliomas: potential role of asymmetrical cell division of neural stem cells

Cited by 65 publications

References 41 publications

Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis

Expression of the stem cell marker CD133 in recurrent glioblastoma and its value for prognosis

Loss ofp53Induces Changes in the Behavior of Subventricular Zone Cells: Implication for the Genesis of Glial Tumors

Subventricular Zone Involvement Characterized by Diffusion Tensor Imaging in Glioblastoma

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