Development of generic metabolic Raman calibration models using solution titration in aqueous phase and data augmentation for in‐line cell culture analysis
Zhijun Zhang,
Zhe Lang,
Gong Chen
et al.
Abstract:This study presents a novel approach for developing generic metabolic Raman calibration models for in‐line cell culture analysis using glucose and lactate stock solution titration in an aqueous phase and data augmentation techniques. First, a successful set‐up of the titration method was achieved by adding glucose or lactate solution at several different constant rates into the aqueous phase of a bench‐top bioreactor. Subsequently, the in‐line glucose and lactate concentration were calculated and interpolated … Show more
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