Development of frontotemporal dementia in a case of bipolar affective disorder: is there a link?

Pavlovic, Aleksandar; Marley, Justin; Sivakumar, V.

doi:10.1136/bcr.09.2010.3303

Cited by 22 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There appears to be an increased risk of bvFTD and nfvPPA before age 60 in those with BD, with documented cases of patients with a lifelong diagnosis of BD evolving to these frontotemporal degenerations. 20 – 22 In these patients, there may be a shared genetic predisposition to both BD and bvFTD, as previously noted from C9orf72 mutations. 23 Investigators have reported C9orf72 mutations in patients with BD preceding bvFTD, with possible genetic expansion from BD to bvFTD.…”

Section: Discussionsupporting

confidence: 53%

Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

Mendez¹

2018

NDT

View full text Add to dashboard Cite

Studies suggest a relationship of manic behavior and bipolar disorder (BD) with behavioral variant frontotemporal dementia (bvFTD). The nature of this relationship is unclear. This report presents a patient with initial manic behavior as the main manifestation of familial bvFTD from a novel progranulin (GRN) mutation. In contrast, there are other reports of a long background of BD preceding a diagnosis of bvFTD. A review of the literature and this patient suggest that manic symptoms result from damage to right frontotemporal neural structures from longstanding BD, as well as from bvFTD and other focal neurological disorders. In addition, there is a subgroup of patients with a probable genetic predisposition to both BD and bvFTD.

show abstract

Section: Discussionsupporting

confidence: 53%

Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

Mendez¹

2018

NDT

View full text Add to dashboard Cite

show abstract

“…A possible link between bipolar disorder and bvFTD has also been suggested by case reports on patients presenting with manic symptoms as a first manifestation of bvFTD 28 , 29 and patients with a lifetime diagnosis of bipolar disorder evolving into bvFTD. 30 , 31 This large clinical overlap in social cognition, executive disturbances, and behavioral profiles might be explained by the involvement of common functional neuroanatomical networks. 32 – 34 …”

Section: Discussionmentioning

confidence: 99%

Late life bipolar disorder evolving into frontotemporal dementia mimic

Dols¹,

Krudop²,

Möller³

et al. 2016

NDT

View full text Add to dashboard Cite

ObjectivesAlthough bipolar disorder has been understood classically as a cyclic disease with full recovery between mood episodes, in the last decade, evidence has accumulated supporting progressive features. The clinical picture of advanced or end-stage bipolar disorder is heterogeneous with possible deficits in cognition and behavior, as illustrated by our case series.CasesFrom our neuropsychiatric outpatient clinic, we describe four cases with bipolar disorder gradually developing a clinical syndrome, including apathy, disinhibition, loss of empathy, stereotypical behavior, and compulsiveness, fulfilling the criteria for possible behavioral variant frontotemporal dementia. All cases were diagnosed with bipolar 1 disorder at least 10 years before the onset of the current symptoms, which were not due to recent mood episodes or switches of medication. In all cases, 3–7 years of follow-up yielded no progression. Repeated neuroimaging was within normal limits. Cerebrospinal fluid biomarker studies were not supportive of underlying neurodegenerative pathology. C9orf72 mutation status was negative in all cases.ConclusionSymptoms fitting the criteria for possible behavioral variant frontotemporal dementia may be present in end-stage of bipolar disorder. An alternative neurodegenerative nature seems unlikely based on repeated normal neuroimaging and the absence of clinical progression. Functional involvement of the frontal-subcortical networks might play a role.

show abstract

“…The initial presentation in both generations is bipolar disorder, suggesting an etiological relationship with the C9ORF72 repeat expansion. Published examples of individuals with bipolar disorder who later developed FTD have not included genetic characterization . Intergenerational expansion of repeated elements in other genes is associated with genetic anticipation and increased disease severity in successive generations .…”

Section: Discussionmentioning

confidence: 99%

C9ORF72 expansion in a family with bipolar disorder

et al. 2013

View full text Add to dashboard Cite

ObjectiveTo investigate the role in bipolar disorder of the C9ORF72 hexanucleotide repeat expansion responsible for frontotemporal lobe dementia and amyotrophic lateral sclerosis.MethodsEighty-nine subjects from a previously described panel of individuals with bipolar disorder ascertained for genetic studies were screened to detect expansion of the C9ORF72 repeat. One two-generation family with bipolar disorder and an expanded repeat was characterized in depth using molecular diagnostics, imaging, histopathology, and neurological and neuropsychological evaluation.ResultsOne proband, with the typical clinical presentation of bipolar disorder, carried an expanded C9ORF72 allele of heterogeneous length between 14 and 20 kilobases (kb) as assessed by Southern blot. The expanded allele was inherited from a parent with atypical, late onset clinical features of bipolar disorder, who subsequently progressed to frontotemporal lobe dementia. The expansion in peripheral blood of the parent ranged from 8.5 to 20 kb. Cultured lymphoblastoid cells from this parent exhibited a homogeneous expansion of only 8.5 kb.ConclusionsThe disease course in the two generations described here demonstrates that expansion of the C9ORF72 may be associated with a form of bipolar disorder that presents clinically with classic phenomenology and progression to neurodegenerative disease. The frequency in our bipolar disorder cohort was only 1%, indicating that C9ORF72 is not a major contributor to bipolar disorder. DNA from cultured cells may be biased towards shorter repeats and nonrepresentative of the endogenous C9ORF72 expansion.

show abstract

Development of frontotemporal dementia in a case of bipolar affective disorder: is there a link?

Cited by 22 publications

References 18 publications

Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

Manic behavior and asymmetric right frontotemporal dementia from a novel progranulin mutation

Late life bipolar disorder evolving into frontotemporal dementia mimic

C9ORF72 expansion in a family with bipolar disorder

Contact Info

Product

Resources

About