Abstract:Using quality by design approaches (dispersion analysis and random balance method), the formulation and technology of powder for oral solution in sachets were developed. It includes paracetamol, ascorbic acid, phenylephrine hydrochloride, and pheniramine maleate. The influence of 27 excipients from 5 functional groups on 11 quality attributes was established by the dispersion analysis. The preferred excipients were selected using the utility function. The quantities of preferable excipients (7 quantitative fac… Show more
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