Development of fipronil resistance, fitness cost, cross-resistance to other insecticides, stability, and risk assessment in Oxycarenus hyalinipennis (Costa)

Wazir, Shabana; Shad, Sarfraz Ali

doi:10.1016/j.scitotenv.2021.150026

Cited by 15 publications

(10 citation statements)

References 57 publications

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“…Particularly, MRs of 4w, 5f, and 5g were 56.8, 61.3, and 56.8%, respectively, whereas MR of 1 was only 30.6%. In compounds 4a−4j and 5a−5e, their aphicidal activity was related to the length of the aliphatic chain R 1 or R 2 . Only MRs at 48 h of 4f (R 9.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Human survival is closely related to agricultural production, but the rapid growth of population has caused food supply and security issues. Fortunately, with the characteristics of ensuring food supply, increasing agricultural production and income, and improving the quality of agricultural products, pesticides appear to be particularly crucial in this dilemma. , Nevertheless, due to the ignorance of the amounts and the rational application of chemical pesticides, it has led to the emergence of pesticide resistance, rampant pests and diseases, pesticide residues, and environmental pollution problems. − With the advantages of unique modes of action and good environmental compatibility, natural active products have been used as precursors to discover new pesticide candidates, which is of great significance to the green pesticide developments. − …”

Section: Introductionmentioning

confidence: 99%

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Construction, Pesticidal Activities, Control Effects, and Detoxification Enzyme Activities of Osthole Ester/Amide Derivatives

Meng

Zhou

et al. 2022

J. Agric. Food Chem.

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Pesticide research and development has entered an era of safety, efficiency, and environmental friendliness. Discovery of effective active products directly or indirectly from plant secondary metabolites as pesticide candidates has been one of the current research focuses. Herein, two series of new ester and amide derivatives were prepared by structural modifications of a natural coumarin-type product osthole at its C-4′ position. Their structures were characterized by IR, mp, 1H NMR, and HRMS. Confirmation of steric configuration of seven compounds was based on single-crystal analysis. Against Tetranychus cinnabarinus Boisduval (Acari: Tetranychidae), (2′E)-3′-ethoxycarbonylosthole (4b) and (2′E)-3′-(n)hexyloxycarbonylosthole (4e) exhibited 3.2 and 3.1 times acaricidal activity of osthole, and particularly, they also showed 2.4 and 2.2 times control efficiency on the 5th day of osthole. Against Aphis citricola Van der Goot (Homoptera: Aphididae), (2′E)-3′-(p-CF3)benzyloxycarbonylosthole (4w), (2′E)-3′-benzylaminocarbonylosthole (5f), and (2′E)-3′-phenylethylaminocarbonylosthole (5g) showed 1.9–2.1-fold aphicidal activity of osthole. Furthermore, the changes in two detoxification enzyme [carboxylesterase (CarE) and glutathione S-transferase (GST)] activities over time in treated T. cinnabarinus were investigated. These results can pave the foundation for future design and preparation of osthole derivatives as botanical agrochemicals.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Construction, Pesticidal Activities, Control Effects, and Detoxification Enzyme Activities of Osthole Ester/Amide Derivatives

Meng

Zhou

et al. 2022

J. Agric. Food Chem.

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“…As the global population expands, it is necessary to satisfy an increasing demand for crops. Pests can cause serious decreases in horticulture and agriculture crop yield and quality, threatening worldwide food security, and insecticides are essential to protect crops from pests in modern agriculture. , Nevertheless, the long-term widespread application of older chemical insecticides has led to serious environmental risks and persistent insect resistance issues for integrated pest management (IPM). − The typical example is Plutella xylostella, one of the most destructive insect pests for Brassicaceae crops, which has developed resistance to about 100 insecticides. − Therefore, it is urgent to develop environmentally benign insecticides with high efficiency, low toxicity, and novel modes of action. , …”

Section: Introductionmentioning

confidence: 99%

“…Notably, among compounds Ip−Iu (R 3 = H), the insecticidal activities of Ir (R 3 = H, R 4 = 1-F, 100% at 5 mg/L) were better than those of other compounds, indicating that R 4 = 1-F had a positive effect on the insecticidal activities.On the basis of above research, to further investigate the effects of positions and types of the substituents R 4 on insecticidal activities, Iv−Iaa (2-R 4 ), Iab−Iag (3-R 4 ), and Iah−Im (4-R 4 ) were synthesized. From Table1, after the types of the substituents R 4 were fixed, generally, the sequence of the effects of the position of the substituents R4 on the insecticidal activities was Ip−Iu (1-R 4 ) > Iah−Iam (4-R 4 ) ≈ Iab−Iag (3-R 4 ) > Iv−Iaa (2-R 4 ). For example, Is (R 4 = 1-Cl), Iae (R 4 = 3-Cl), and Iak (R 4 = 4-Cl) exhibited 70, 50, and 50% insecticidal…”

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confidence: 99%

Bioactivity-Guided Synthesis Accelerates the Discovery of Evodiamine Derivatives as Potent Insecticide Candidates

Liu

Shi

Zhong

et al. 2022

J. Agric. Food Chem.

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Pests threaten worldwide food security by decreasing crop yields and damaging their quality. Natural product-based molecular design and structural optimization have been one of the most effective ways to innovate pesticides for integrated insect management. To continue our previous studies on the discovery of insecticidal lead, a series of evodiamine derivatives were designed, synthesized, and evaluated for their insecticidal activities. The bioassay results demonstrated that compounds Ian and Iao exhibited 90 and 80% insecticidal activities against Mythimna separata at 2.5 mg/L, respectively, which were superior to evodiamine (10% at 10 mg/L), matrine (45% at 600 mg/L), and rotenone (30% at 200 mg/L). Compounds Ian−Iap showed 90% insecticidal activities against Plutella xylostella at 1.0 mg/L, far more potent than those of evodiamine, matrine, and rotenone. Compound Ian displayed 60% insecticidal activity against Helicoverpa armigera at 5.0 mg/L, while evodiamine, matrine, and rotenone showed very poor activities. The study on the insecticidal mechanism of action by a calcium imaging experiment indicated that the insect ryanodine receptors (RyRs) could be the potential target of Ian. Furthermore, the molecular docking indicated that Ian anchored in the binding site of the RyR of P. xylostella. The above results manifested the potential of evodiamine derivatives as potent insecticide candidates.

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“…The altered fitness landscape of the drugged environment can promote aggressive biology, but can also induce "collateral sensitivities" to novel agents [27]. This concept, also known as negative cross resistance, has been applied to identify new strategies to treat the evolution of resistance in bacterial infections [28], malaria [29], herbicides [30], and pesticides [31].…”

Section: Introductionmentioning

confidence: 99%

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Ware

Thomas

Olawuni

et al. 2022

Preprint

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Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone therapy-resistant and metastatic prostate cancer remains a major cause of cancer-related death globally. The mainstay of treatment for advanced prostate cancer is targeting of androgen receptor signaling, including androgen deprivation therapy plus second-generation androgen receptor blockade (e.g., enzalutamide, apalutamide, darolutamide), and/or androgen synthesis inhibition (abiraterone). While these agents have significantly prolonged the lives of patients with advanced prostate cancer, the evolution of resistance to these treatments in nearly universal. This therapy resistance is mediated by diverse mechanisms, including both androgen receptor-dependent mechanisms, such as androgen receptor mutations, amplifications, alternative splicing, and amplification, as well as non-androgen receptor-mediated mechanisms, such as lineage plasticity toward neuroendocrine-like or epithelial-mesenchymal transition (EMT)-like lineages. Our prior work identified the EMT transcriptional regulator Snail as critical to hormonal therapy resistance and is commonly detected in human metastatic prostate cancer. In the current study, we sought to interrogate the actionable landscape of EMT-mediated hormone therapy resistant prostate cancer to identify synthetic lethality and collateral sensitivity approaches to treating this aggressive, therapy-resistant disease state. Using a combination of high-throughput drug screens and multi-parameter phenotyping by confluence imaging, ATP production, and phenotypic plasticity reporters of EMT, we identified candidate synthetic lethalities to Snail-mediated EMT in prostate cancer. These analyses identified multiple actionable targets, such as XPO1, PI3K/mTOR, aurora kinases, c-MET, polo-like kinases, and JAK/STAT as synthetic lethalities in Snail+ prostate cancer. We validated these targets in a subsequent validation screen in an LNCaP-derived model of resistance to sequential androgen deprivation and enzalutamide. This follow-up screen provided validation of inhibitors of JAK/STAT and PI3K/mTOR as therapeutic vulnerabilities for both Snail+ and enzalutamide-resistant prostate cancer.

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Development of fipronil resistance, fitness cost, cross-resistance to other insecticides, stability, and risk assessment in Oxycarenus hyalinipennis (Costa)

Cited by 15 publications

References 57 publications

Construction, Pesticidal Activities, Control Effects, and Detoxification Enzyme Activities of Osthole Ester/Amide Derivatives

Construction, Pesticidal Activities, Control Effects, and Detoxification Enzyme Activities of Osthole Ester/Amide Derivatives

Bioactivity-Guided Synthesis Accelerates the Discovery of Evodiamine Derivatives as Potent Insecticide Candidates

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

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