Development of fibrinous thrombus analogue for in-vitro abdominal aortic aneurysm studies

The biaxial mechanical behaviour of abdominal aortic aneurysm intraluminal thrombus: Classification of morphology and the determination of layer and region specific properties

“…Upon excision, all samples were stored frozen at À 20 1C until further analysis (van Dam et al, 2006;Hinnen et al, 2007;Gasser et al, 2008).…”

“…Although, several studies have reported a negligible effect on the mechanical properties of arterial tissue due to freezing (Adham et al, 1996;Stemper et al, 2007;Virues Delgadillo et al, 2010) and intraluminal thrombus due to freezing (van Dam et al, 2006;Hinnen et al, 2007), testing the tissue fresh would be more appropriate. Unfortunately, due to logistics this was not an option for this study.…”

The mechanical role of thrombus on the growth rate of an abdominal aortic aneurysm

“…[13][14][15] All studies concluded that thrombus significantly lowers AAA wall stress and that the effect was stronger for thicker and stiffer thrombi. Recently, material properties of thrombus were re-evaluated with compression and shear experiments, [16][17][18] leading to far lower elastic moduli than was determined previously by uniaxial or biaxial stretching experiments. [19][20][21][22] The aim of this study is to evaluate the effect of thrombus on the wall stress in patient-specific AAA models, in light of the recently obtained material properties.…”

Pathopysiology of Abdominal Aortic Aneurysm Rupture and Expansion: New Insight on an Old Problem

“…Vande Geest et al performed planar biaxial testing on the luminal layer of ILT and estimated the maximum tangential modulus to be 23.1 and 20.1 N/cm 2 in the longitudinal and circumferential directions, respectively (Vande Geest et al, 2006b). Di Marino et al (Di Marino et al, 1998) estimated the range of ILT Young's modulus to be 5-20 N/cm 2 , whereas Hinnen et al (Hinnen et al, 2007) 1.3-5.9 N/cm 2 . It is clear that there is a wide variation in the mechanical properties of ILT.…”