2007
DOI: 10.1590/s0100-879x2006005000094
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Abstract: The role of acetylcholine in the central and peripheral nervous systems is well established in adults. Cholinergic modulation of vascular functions and body fluid balance has been extensively studied. In the embryo-fetus, cholinergic receptors are widespread in the peripheral and central systems, including smooth muscle and the epithelial lining of the cardiovascular, digestive, and urinary systems, as well as in the brain. Fetal nicotine and muscarinic receptors develop in a pattern (e.g., amount and distribu… Show more

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Cited by 6 publications
(9 citation statements)
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“…The α7 nAChR subtype is believed to be involved in the regulation of neuronal growth, differentiation, synapse formation and synaptic plasticity during the development of the human brain (Falk et al, 2002). The α7 receptors, which mediate the effects of developmental neurotoxicants, increase glutamate release onto postsynaptic NMDA receptors (Mao et al, 2007). Overactivation of α7 nAChRs during development results in neuronal cell death, whereas stimulation in adult animals is neuroprotective (Laudenbach et al, 2002) In the murine hippocampal dentate gyrus, α7 subunit appears to be essential for normal survival, maturation and integration of adult-born neurons (Campbell et al 2010).…”
Section: Physiological Role Of Nachrs During Brain Developmentmentioning
confidence: 99%
“…The α7 nAChR subtype is believed to be involved in the regulation of neuronal growth, differentiation, synapse formation and synaptic plasticity during the development of the human brain (Falk et al, 2002). The α7 receptors, which mediate the effects of developmental neurotoxicants, increase glutamate release onto postsynaptic NMDA receptors (Mao et al, 2007). Overactivation of α7 nAChRs during development results in neuronal cell death, whereas stimulation in adult animals is neuroprotective (Laudenbach et al, 2002) In the murine hippocampal dentate gyrus, α7 subunit appears to be essential for normal survival, maturation and integration of adult-born neurons (Campbell et al 2010).…”
Section: Physiological Role Of Nachrs During Brain Developmentmentioning
confidence: 99%
“…The most surprising finding, in fact, was the number of cholinergic genes that decreased at the end of pregnancy (Table 1). While much is known of the changes in the cholinergic system during fetal development [25,26], very little is known of its role in the maternal brain during pregnancy. In sheep and goats, the cholinergic system seems to regulate maternal recognition of offspring and maternal attachment after parturition [27].…”
Section: Resultsmentioning
confidence: 99%
“…The first step was to describe prenatal exposure to atropinic drugs. Then, multinomial logistic regressions were used to compare maternal and child characteristics according to the exposure status (atropinic burden = 0, [1][2][3], [3][4][5][6][7][8][9], ≥9).…”
Section: Discussionmentioning
confidence: 99%