Development of favipiravir loaded PLGA nanoparticles entrapped in in-situ gel for treatment of Covid-19 via nasal route

Gattani, Vaishnavi; Dawre, Shilpa

doi:10.1016/j.jddst.2022.104082

Cited by 8 publications

(1 citation statement)

References 48 publications

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“… 163 Lopinavir (LPV), an antiviral drug, could be loaded into PLGA nanoparticles coated with macrophage membranes (PLGA-LPV@M) to reduce tissue viral loads in mouse models. 164 Other anti-inflammatory and antiviral drugs, such as celecoxib, 165 quinine, 166 oseltamivir-phosphate, 167 favipiravir, 168 and fingolimod, 169 could be coated on or encapsulated into PLGA polymeric nanoparticles.…”

Section: Biomaterials Help To Anti-sars-cov-2 Strategiesmentioning

confidence: 99%

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

Hu,

Liu,

Zhang

et al. 2024

ACS Omega

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The coronavirus disease-19 (COVID-19) pandemic has had a significant impact on human life worldwide since 2019. Specific vaccines and antiviral agents are the most effective means of preventing and treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Additionally, antiviral protective equipment and early diagnosis also contribute to controlling the spread of COVID-19. The utilization of biomaterials in medicine and pharmaceuticals is crucial to ensure the positive impact of vaccines, antiviral agents, and protective equipment. In this review, we discuss the application of various types of biomaterials, including polymers, lipid nanoparticles, inorganic biomaterials, protein-or peptide-associated biomaterials, selfassembled biomaterials, and other biomaterials, for the vaccine, treatment, and prevention of COVID-19. Finally, we provide a perspective on future opportunities and challenges for developing biomaterials to combat other viral outbreaks and diseases.

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Section: Biomaterials Help To Anti-sars-cov-2 Strategiesmentioning

confidence: 99%

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

Hu,

Liu,

Zhang

et al. 2024

ACS Omega

View full text Add to dashboard Cite

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Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control

Araste,

Bakker,

Zandieh-Doulabi

2023

J Nanopart Res

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The ongoing battle against viral infections highlighted so recently by the COVID-19 pandemic demonstrates the need to develop new approaches using nanotechnology in antiviral strategies. Nanoparticles have emerged as promising tools in the fight against viral outbreaks, offering various options for application such as biosensors, vaccine nanoparticles, disinfectants, and functionalized nanoparticles. In this comprehensive review, we evaluate the role of nanoparticles in pandemic control, exploring their potential applications, benefits, and associated risks. We first discuss the importance of nanotechnology in viral outbreak management, particularly in vaccine development. Although lipid nanoparticles play a crucial role in mRNA vaccines, there are concerns about their potential side effects. Although functionalization of protective face masks using metallic nanoparticles has emerged as a sustainable alternative to disposable masks, reducing waste production and enhancing virus filtration, improper disposal of such masks leads to environmental contamination and potential ecological harm. Second, we address the potential adverse effects associated with nanoparticle-based vaccines containing polyethylene glycol and other vaccine components, which trigger autoimmune diseases and alter menstrual cycles. To manage outbreaks effectively, we must minimize such potential risks and environmental impacts. Thus, when developing effective strategies for future pandemic control, it is crucial to understand the advantages and challenges associated with nanoparticle usage.

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Nanomaterials as a Versatile Tool for COVID-19 Treatment

Zeinali,

Moafian,

Arshad

et al. 2024

BioNanoSci.

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Development of favipiravir loaded PLGA nanoparticles entrapped in in-situ gel for treatment of Covid-19 via nasal route

Cited by 8 publications

References 48 publications

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

The Application of Biomaterials for the Vaccine, Treatment, and Detection of SARS-CoV-2

Potential and risks of nanotechnology applications in COVID-19-related strategies for pandemic control

Nanomaterials as a Versatile Tool for COVID-19 Treatment

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