Development of Fast Disintegration Tablets As Oral Drug Delivery System-A Review

Beri, Chiman; Sacher, Isha

doi:10.30750/ijpbr.1.3.13

Cited by 10 publications

(4 citation statements)

References 22 publications

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“…For drugs that are just marginally soluble in water, this technique is very helpful. Fast nanoparticle dissolution, which increases absorption and, in turn, increases bioavailability and lowers dose requirements, are two further benefits of this technique [16].…”

Section: Nanonizationmentioning

confidence: 99%

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

PREETI¹,

AGARWAL²,

AGARWAL³

2022

Asian J Pharm Clin Res

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Due to the oral route’s comfort, convenience, and patient compliance, it is the most important and advised method for administering medications. The typical oral unit dosage form that is most frequently employed is the tablet. The patients experience problems swallowing during pill administration. Tablets called mouth dissolving tablets (MDTs) that quickly dissolve in the mouth without the need of water can lessen this issue. As a new drug delivery system, MDTs have begun to acquire recognition and appeal. By developing a simple-to-use dosage form that will increase compliance, they hope to increase the safety and efficiency of therapeutic molecules. For individuals with dysphasia, such as children, the elderly, and those who are mentally ill, mouth dispersing medications are becoming more reliable. The introduction, benefits, drawbacks, excipients employed, different formulation procedures, and evaluation factors are all covered in this review.

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Section: Nanonizationmentioning

confidence: 99%

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

PREETI¹,

AGARWAL²,

AGARWAL³

2022

Asian J Pharm Clin Res

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“…To use these types of disintegrating agents, the ODT should possess certain ideal characteristics. [4][5][6][7] Ideal Character of Different Disintegrating Agent:…”

Section: Introductionmentioning

confidence: 99%

Review Article A Detailed Study on Disintegrating Agents and an Overview on Oral Disintegration Tablet

Sneha

2024

IJSREM

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Nowadays, the administration of drugs through the oral route is becoming less common, accounting for only about 75% of all drug administrations compared to other routes. A new type of dosage form called oral disintegrating tablets has gained popularity in recent decades due to their rapid disintegration and dissolution. These tablets disintegrate in the mouth within seconds (25-40 seconds) without the need for water, as the oral mucosa alone is sufficient for the tablet to dissolve. The selection of a suitable disintegrating agent is crucial to achieve optimal bioavailability. A preparation may contain one or multiple disintegrating agents to ensure maximum disintegration and bioavailability. These tablets are also known as Oro disintegration tablets. Disintegrating agents are rarely used in solid unit dosage forms, typically comprising only 1-10% of the total dosage unit. The use of super disintegrates in these tablets enhances the drug's efficacy by promoting rapid dissolution. Various disintegrating agents, super disintegrates, and excipients are employed in the formulation of oral disintegrating tablets. This review article provides an overview of different types of disintegrates, including natural, polymer, and synthetic ones, as well as formulation methods, applications, and various parameters of oral disintegrating tablets. These tablets are particularly well-liked by pediatric patients and those who prefer generic medications. Oral disintegrating tablets are highly preferred in the treatment of dysphagia and oral disorders among patients. Keywords: - Oral disintegrating tablets, Oro disintegrating tablets, Disintegrates, Super disintegrates and Fast dissolution tablet.

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“…16 There are various techniques and approaches used in improving FDTs such as lyophilization, spray drying, sublimation, molding, mass extrusion, cotton candy process, melt granulation, phase transition process, effervescent method, floss blend, floss processing, floss chopping and conditioning, direct compression, nanonization, and fast dissolving films. 17,18 19 This study was conducted with the objectives to improve patient compliance with an effective drug delivery system by formulating and evaluating the oral FDTs of ondansetron HCl using natural polymers.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants

Maharjan,

HS,

Gururaj S.

et al. 2023

Journal of Karnali Academy of Health Sciences

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Background: Fast disintegrating tablet (FDT) of ondansetron has better patient compliance as it is easy to swallow for the treatment of nausea and vomiting. Moreover, fast absorption, rapid onset, reduced loss of drugs, and enhanced bioavailability are making oral dispersible systems a better drug delivery system. This research was conducted with the objective to formulate and evaluate the oral FDT of ondansetron HCl using natural polymers. Methods: The tablets were formulated employing the direct compression technique using different ratios of natural super disintegrants such as spray-dried banana powder, ispaghula husk powder, and combination of both polymers. The developed powders were subjected to the pre-compression parameters and the powders were punched using a single-head rotatory compression machine. The formulated 200 mg tablets were subjected to post-compression evaluation. Results: The Fourier-transform infrared spectroscopy studies showed no chemical interaction between pure drugs, natural super disintegrants, and other excipients. Formulation F6 containing ispaghula husk powder in a 1:4 ratio demonstrated 98.60±0.003% of drug release within 10 minutes indicating the best formulation. Conclusion: FDT of ondansetron was considered the best formulation in the drug delivery system which followed the Higuchi model with the Fickian release.

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Development of Fast Disintegration Tablets As Oral Drug Delivery System-A Review

Cited by 10 publications

References 22 publications

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

An Overview on Mouth Dissolving Tablet: From Manufacturing and Patented Technique to Quality Control Test

Review Article A Detailed Study on Disintegrating Agents and an Overview on Oral Disintegration Tablet

Formulation and Evaluation of Fast Disintegrating Tablets of Ondansetron Using Natural Superdisintegrants

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