Development of fast and three-dimensional focused x-ray luminescence tomography system

Fang, Yile; Zhang, Yibing; Lun, Michael C.; Anker, Jeffrey N.; Wang, Ge; Li, Changqing

doi:10.1117/12.2654091

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Our experiments have shown that we have achieved good DICE similarity coefficients, especially for the case with four detectors. In future studies, we plan to apply this imaging system in preclinical applications [10], [11].…”

Section: Discussionmentioning

confidence: 99%

Quantitative study of x-ray luminescence computed tomography

Fang,

Zhang,

2024

Medical Imaging 2024: Clinical and Biomedical Imaging

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Pencil beam X-ray luminescence computed tomography (XLCT) is a developing hybrid molecular imaging modality combining the merits of both x-ray imaging (high spatial resolution) and optical imaging (high sensitivity). Narrow x-ray beam based XLCT imaging has shown promise for high spatial resolution imaging and high molecular sensitivity, but so far there is no quantitative study of XLCT imaging for x-ray excitable nanophosphor targets in deep tissue. In this study, we have for the first time performed quantitative study on the reconstructed nanophosphor target concentrations through phantom experiments. We have upgraded our XLCT imaging system by mounting four optical fiber cables to increase the efficiency in collecting x-ray induced optical photons. We also used a piece of scintillator crystal to monitor the x-ray pencil beam's intensity to sense automatic phantom boundary and to perform parallel beam based CT imaging simultaneously, which can be used to verify the true locations of the reconstructed XLCT targets. We have scanned a cylindrical agar phantom containing twelve targets filled with three different nanophosphor concentration (2.5 mg/ml, 5 mg/ml, and 10 mg/ml) and reconstructed XLCT images with the filtered back-projection (FBP) algorithm. We have conducted quantitative analysis of the phantom experimental results employing different numbers of optical fiber cables and found the reconstructed signals ratio is calculated to be 1: 2.17: 3.55, which is close to the ground truth target concentrations ratio of 1:2:4.

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Section: Discussionmentioning

confidence: 99%

Quantitative study of x-ray luminescence computed tomography

Fang,

Zhang,

2024

Medical Imaging 2024: Clinical and Biomedical Imaging

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“…Based on the previous studies [15][19], we built a pencil beam based XLCT imaging system with four detectors. In the following numerical simulations, we investigated the effect of detector number up to 16 detectors, while in the physical experimental setup, we only utilized 4 detectors due to the limited resource.…”

Section: Methodsmentioning

confidence: 99%

“…Fig. 1 shows the schematics of the four- channel XLCT system which was developed from the single-channel XLCT system in our lab [16][15][13]. Fig.…”

Section: Methodsmentioning

confidence: 99%

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Pencil Beam Based X-ray Luminescence Computed Tomography Imaging of Deep Targets Three-dimensionally and Quantitatively

Fang,

Zhang,

2024

Preprint

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X-ray luminescence computed tomography (XLCT), especially pencil beam based XLCT, has been emerged for more than 15 years because it can image deep targets in tissue with high spatial resolution and high measurement sensitivity. However, its application is limited by long scanning time and the tedious efforts of finite element mesh generation for model based reconstruction. Our previous study has addressed the imaging speed issue. In this study, we propose to reconstruct XLCT with weighted filtered back projection (wFBP) which makes it possible to perform XLCT imaging three dimensionally for complex objects at a high spatial resolution. We have also proposed measurements with multiple detectors to obtain quantitative XLCT images. To evaluate the proposed methods, we have performed numerical simulations and different sets of phantom experiments including phantom experiments with a control contrast target, different concentrations, and different target sizes. We have also successfully reconstructed deep targets with a diameter of approximately 0.15 mm. For the phantom experiments with targets of different concentrations, using a 4-channel XLCT system and the wFBP, we achieved the ratio of 3.8:1.79:1, closely resembling the ground truth ratio of 4:2:1. Lastly, we have, for the first time, reconstructed different 3D targets at high spatial resolution, successfully, including a printed M target, a triangular hollow bar, and a hot background cuboid with “UCM Li Lab” slots. Our results indicate that the proposed wFBP advances the promising XLCT technology and makes it ready for in vivo studies in the future.

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Superfast Scan of Focused X-Ray Luminescence Computed Tomography Imaging

Fang,

Zhang,

Lun

et al. 2023

IEEE Access

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X-ray luminescence computed tomography (XLCT) is a hybrid molecular imaging modality having the high spatial resolution of x-ray imaging and high measurement sensitivity of optical imaging. Narrow x-ray beam based XLCT imaging has shown promise for high spatial resolution imaging of luminescent targets in deep tissues, but the slow acquisition speed limits its applications. In this work, we have introduced a superfast XLCT scan scheme based on the photon counter detector and a fly-scanning method. The new scan scheme is compared with three other scan methods. We have also designed and built a single-pixel x-ray detector to detect object boundaries automatically. With the detector, we can perform the parallel beam CT imaging with the XLCT imaging simultaneously. We have built the prototype XLCT imaging system to verify the proposed scan scheme. A phantom embedded with a set of four side-by-side cylindrical targets was scanned. With the proposed superfast scan scheme, we have achieved 43 seconds per transverse scan, which is 28.6 times faster than before with slightly better XLCT image quality. The superfast scan allows us to perform 3D pencil beam XLCT imaging in the future.INDEX TERMS X-ray luminescence computed tomography, optical imaging, x-ray imaging, optical tomography, scanning schemes.

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Development of fast and three-dimensional focused x-ray luminescence tomography system

Cited by 5 publications

References 19 publications

Quantitative study of x-ray luminescence computed tomography

Quantitative study of x-ray luminescence computed tomography

Pencil Beam Based X-ray Luminescence Computed Tomography Imaging of Deep Targets Three-dimensionally and Quantitatively

Superfast Scan of Focused X-Ray Luminescence Computed Tomography Imaging

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