Development of fabrication technique in nano-scale resveratrol by collagen

Cherng, Juin–Hong; Chang, Shu–Jen; Yeh, Jue–Zong; Hung, Yao‐Wen; Lai, Hsin‐Chih; Liou, Nien-Hsien; Li, Chung–Hsing; Tsao, Chung–Ang; Liu, Cheng–Che

doi:10.1504/ijnt.2013.058124

Cited by 3 publications

(13 citation statements)

References 22 publications

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“…RSV reduces levels of pro-inflammatory cytokines, thus inhibiting PAP and P2-receptor signalling through MAPK, cJun, and JNK. It promotes an anti-inflammatory response 27,30 by inhibiting PG synthesis through the inhibitory effect of cyclooxygenase-1 with RSV. 31 We thus believe that collagen/RSV scaffolds facilitate epithelium repair, while RSV inhibits proliferation and increases differentiation of osteoblasts from stem cells.…”

Section: Discussionmentioning

confidence: 99%

“…24 The pharmacological enrichment of hASCs for osteoprogenitors could thus potentially provide a novel treatment for critical bone defects and for regenerative medicine. [25][26][27] The present study investigated the effects of RSV in combination with a collagen scaffold on hASC differentiation through in vitro and in vivo experiments on engineering tissue for the craniofacial structure.…”

Section: Introductionmentioning

confidence: 99%

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Combination of resveratrol‐containing collagen with adipose stem cells for craniofacial tissue‐engineering applications

Wang

et al. 2018

International Wound Journal

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Repair and regeneration of craniofacial tissues is particularly challenging because they comprise a complex structure of hard and soft tissues involved in intricate functions. This study combined collagen scaffolds and human adipose stem cells (hASCs) for oral mucosal and calvarial bone regeneration by using resveratrol (RSV), which affects the differentiation of mesenchymal stem cells. We have evaluated the effect of collagen scaffold-containing RSV (collagen/RSV) scaffolds both in vitro and in vivo for their wound healing and bone regeneration potential. Scanning electron microscopy and immunostaining results reveal that hASCs adhere well to and proliferate on both collagen scaffolds and collagen/RSV scaffolds. Oral mucosal lesion experiments demonstrated that the collagen/RSV scaffold is more effective in wound closure and contraction than the collagen scaffold. The micro-computed tomography (μCT) images of calvarial bone display regenerating bone in defects covered with hASCs on collagen/RSV scaffolds that are more visible than that in defects covered with hASCs on a collagen scaffolds. RSV was more effective at inducing hASC differentiation on the collagen scaffold, suggesting that collagen/RSV scaffolds can provide useful biological cues that stimulate craniofacial tissue formation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination of resveratrol‐containing collagen with adipose stem cells for craniofacial tissue‐engineering applications

Wang

et al. 2018

International Wound Journal

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“…[12][13][14][15] At present, nanotechnology-based Res include nanoemulsion, [16][17][18] nanoethosomes and transfersomes, 19 halloysite clay nanotubes, 20 polymeric nanoparticles, 21-24 solid lipid nanoparticles 25 and collagen nanoparticles. 26 It could be seen that all above nano-Res contain inert carrier. However, the usage of carriers suffers many drawbacks.…”

Section: Introductionmentioning

confidence: 96%

Carrier-Free, Pure Resveratrol Micro-/Nanoribbon: Simple Preparation and Enhanced Bioactivity

Lu¹,

Zhao²,

Che³

et al. 2014

mater focus

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Drugs in nanoscale are often encapsulated in inert carriers, and problems such as low drug loading content and possible undesirable side effects caused by the carriers remain a serious challenge. In this work, a carrier-free, pure micro-/nano resveratrol (m-Res) were prepared by a simple calcination method. The scanning electron microscopy (SEM) image showed that the as-prepared Res appeared ribbon-like with widths range from 200 to 800 nm. The powder X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) analysis confirmed that the molecular structure and thermal behavior of the m-Res were not changed in compared to that of raw Res. Further studies show that the m-Res appeared significantly increased solubility and enhanced cytotoxicity against cancer cell. The solubility of the m-Res is about 7 times increased and the value of IC 50 decreased about 42% for HeLa cells and 44% for HepG2 cells when compared to that of raw Res. The results suggesting that this carrier-free, pure m-Res could has potential application in inhibiting cancer growth.

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confidence: 99%

“…Collagen is a sturdy emulsifier made in the human body (Cherng et al, 2013). RSV is an antioxidant which has anti-inflammatory properties (Cherng et al, 2013), allowing it to reduce reactive oxygen species (ROS) levels, which can induce cancer when in excess (Arnarson, 2019). However, RSV is not absorbed easily by the human body since it is excreted easily, making it less effective (Cherng et al, 2013).…”

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confidence: 99%

Collagen as a Nanonization Strategy for Enhancing Natural Antioxidants in Cancer Treatment

Lin,

Cherng

2023

J Stud Res

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The purpose of this research was to determine whether nanoscale resveratrol (RSV), collagen added to RSV, is more effective than regular RSV. Collagen is a sturdy emulsifier made in the human body. RSV is an antioxidant which has anti-inflammatory properties, allowing it to reduce reactive oxygen species (ROS) levels, which can induce cancer when in excess. However, RSV is not absorbed easily by the human body since it is excreted easily, making it less effective. This research paper was focused on overcoming the low bioavailability of RSV through reducing particle size. The concept behind this is nanotechnology, using technology to study 1 to 100 nanometer structures. Smaller RSV particles have increased surface area, which dissolves faster in the bloodstream. The hypothesis is that RSV particles would decrease by 8 times the volume, while the ROS levels in 3T3L1 cells would decrease with nanoscale RSV by 50%. The particle size distribution of RSV was measured with a spectrophotometer, while the ROS levels in 3T3L1 cells were measured by ELISA. The collagen-RSV solution had a greater peak than the regular RSV solution, indicating the particle size of RSV decreased after adding collagen. Also, the nanoscale RSV could reduce ROS levels more than regular RSV. This evidence supports the hypothesis that nanoscale RSV is effective in reducing ROS levels, and is smaller than regular RSV.

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Development of fabrication technique in nano-scale resveratrol by collagen

Cited by 3 publications

References 22 publications

Combination of resveratrol‐containing collagen with adipose stem cells for craniofacial tissue‐engineering applications

Combination of resveratrol‐containing collagen with adipose stem cells for craniofacial tissue‐engineering applications

Carrier-Free, Pure Resveratrol Micro-/Nanoribbon: Simple Preparation and Enhanced Bioactivity

Collagen as a Nanonization Strategy for Enhancing Natural Antioxidants in Cancer Treatment

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