Development of experimental techniques for antibiotics detection in aqueous solutions: Real-time microwave dielectrometry and UV-Vis spectrophotometry study

Abstract

Microwave dielectrometry and UV/Vis spectrophotometry methods have been used to study the aqueous solutions of selected antibiotics of different classes: lincomycin hydrochloride, levofloxacin hemihydrate, amikacin sulfate, and gentamicin sulfate. The microwave dielectrometry technique demonstrates high sensitivity of complex permittivity values of antibiotics water solutions from antibiotics concentration in such solutions. In our study, the microwave dielectrometry data are validated by the UV-Vis spectrophotometry results for levofloxacin and lincomycin aqueous solutions. The Fisher’s correlation coefficients for the electromagnetic waves absorbance values, obtained by the different methods, are close to unity for the mentioned antibiotics. The obtained experimental results confirm that the microwave dielectrometry method developed by us is prospective to be applied for antibiotics determination in aqueous solutions including environmental water samples.