Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient

Vanrossomme, Axel; Chodzynski, Kamil; Boudjeltia, Karim Zouaoui

doi:10.1038/s41598-021-88420-3

Cited by 2 publications

(1 citation statement)

References 23 publications

(3 reference statements)

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“…A previous pilot study evaluated cerebral aneurysm volume changes, showing the ability of 4D CTA to capture volume changes of approximately 3 mm 3 , where a sinusoidal pressure wave of 90 bpm was applied to a spherical phantom. [8] This study related the measured expansion to the input settings, instead of using a reference imaging technique. A validation study for 4D CTA for capturing vessel movement using a phantom with a reference measurement is lacking in literature.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Computed Tomography Angiography for capturing vessel wall motion: A phantom study for optimal image reconstruction

Stam,

Linden,

Oostveen

et al. 2023

PLoS ONE

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Background Reliably capturing sub-millimeter vessel wall motion over time, using dynamic Computed Tomography Angiography (4D CTA), might provide insight in biomechanical properties of these vessels. This may improve diagnosis, prognosis, and treatment decision making in vascular pathologies. Purpose The aim of this study is to determine the most suitable image reconstruction method for 4D CTA to accurately assess harmonic diameter changes of vessels. Methods An elastic tube (inner diameter 6 mm, wall thickness 2 mm) was exposed to sinusoidal pressure waves with a frequency of 70 beats-per-minute. Five flow amplitudes were set, resulting in increasing sinusoidal diameter changes of the elastic tube, measured during three simulated pulsation cycles, using ECG-gated 4D CTA on a 320-detector row CT system. Tomographic images were reconstructed using one of the following three reconstruction methods: hybrid iterative (Hybrid-IR), model-based iterative (MBIR) and deep-learning based (DLR) reconstruction. The three reconstruction methods where based on 180 degrees (half reconstruction mode) and 360 degrees (full reconstruction mode) raw data. The diameter change, captured by 4D CTA, was computed based on image registration. As a reference metric for diameter change measurement, a 9 MHz linear ultrasound transducer was used. The sum of relative absolute differences (SRAD) between the ultrasound and 4D CTA measurements was calculated for each reconstruction method. The standard deviation was computed across the three pulsation cycles. Results MBIR and DLR resulted in a decreased SRAD and standard deviation compared to Hybrid-IR. Full reconstruction mode resulted in a decreased SRAD and standard deviations, compared to half reconstruction mode. Conclusions 4D CTA can capture a diameter change pattern comparable to the pattern captured by US. DLR and MBIR algorithms show more accurate results than Hybrid-IR. Reconstruction with DLR is >3 times faster, compared to reconstruction with MBIR. Full reconstruction mode is more accurate than half reconstruction mode.

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Section: Introductionmentioning

confidence: 99%

Dynamic Computed Tomography Angiography for capturing vessel wall motion: A phantom study for optimal image reconstruction

Stam,

Linden,

Oostveen

et al. 2023

PLoS ONE

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Feasibility of capturing vessel expansion with 4D‐CTA: Phantom study to determine reproducibility, spatial and temporal resolution

Linden,

Stam,

Aquarius

et al. 2024

Medical Physics

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BackgroundDynamic Computed Tomography Angiography (4D CTA) has the potential of providing insight into the biomechanical properties of the vessel wall, by capturing motion of the vessel wall. For vascular pathologies, like intracranial aneurysms, this could potentially refine diagnosis, prognosis, and treatment decision‐making.PurposeThe objective of this research is to determine the feasibility of a 4D CTA scanner for accurately measuring harmonic diameter changes in an in‐vitro simulated vessel.MethodsA silicon tube was exposed to a simulated heartbeat. Simulated heart rates between 40 and 100 beats‐per‐minute (bpm) were tested and the flow amplitude was varied, resulting in various changes of tube diameter. A 320‐detector row CT system with ECG‐gating captured three consecutive cycles of expansion. Image registration was used to calculate the diameter change. A vascular echography set‐up was used as a reference, using a 9 MHz linear array transducer. The reproducibility of 4D CTA was represented by the Pearson correlation (r) between the three consecutive diameter change patterns, captured by 4D CTA. The peak value similarity (pvs) was calculated between the 4D CTA and US measurements for increasing frequencies and was chosen as a measure of temporal resolution. Spatial resolution was represented by the Sum of the Relative Percentual Difference (SRPD) between 4D CTA and US diameter change patterns for increasing amplitudes.ResultsThe reproducibility of 4D CTA measurements was good (r ≥ 0.9) if the diameter change was larger than 0.3 mm, moderate (0.7 ≤ r < 0.9) if the diameter change was between 0.1 and 0.3 mm, and low (r < 0.7) if the diameter change was smaller than 0.1 mm. Regarding the temporal resolution, the amplitude of 4D CTA was similar to the US measurements (pvs ≥ 90%) for the frequencies of 40 and 50 bpm. Frequencies between 60 and 80 bpm result in a moderate similarity (70% ≤ pvs < 90%). A low similarity (pvs < 70%) is observed for 90 and 100 bpm. Regarding the spatial resolution, diameter changes above 0.30 mm result in SRPDs consistently below 50%.ConclusionIn a phantom setting, 4D CTA can be used to reliably capture reproducible tube diameter changes exceeding 0.30 mm. Low pulsation frequencies (40 or 50 bpm) provide an accurate measurement of the maximum tube diameter change.

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Development of experimental ground truth and quantification of intracranial aneurysm pulsation in a patient

Cited by 2 publications

References 23 publications

Dynamic Computed Tomography Angiography for capturing vessel wall motion: A phantom study for optimal image reconstruction

Dynamic Computed Tomography Angiography for capturing vessel wall motion: A phantom study for optimal image reconstruction

Feasibility of capturing vessel expansion with 4D‐CTA: Phantom study to determine reproducibility, spatial and temporal resolution

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