Development of Ethyl Cellulose-based Formulations: A Perspective on the Novel Technical Methods

Ahmadi, Parisa; Jahanban-Esfahlan, Ali; Ahmadi, Azam; Tabibiazar, Mahnaz; Mohammadifar, Mohammad Amin

doi:10.1080/87559129.2020.1741007

Cited by 56 publications

(20 citation statements)

References 155 publications

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“…These properties enable ethyl cellulose in applications such as food packaging, drug delivery, and emulsion fabrication. [14,15] The high mechanical tensile strength of 47-72 MPa of ethyl cellulose benefits the robustness when compositing it with other materials. [16] Inspired by these merits, we utilized ethyl cellulose to prepare the thin SE membrane.…”

Section: Introductionmentioning

confidence: 99%

Amphipathic Binder Integrating Ultrathin and Highly Ion‐Conductive Sulfide Membrane for Cell‐Level High‐Energy‐Density All‐Solid‐State Batteries

Cao

Sun

et al. 2021

Advanced Materials

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Current sulfide solid‐state electrolyte (SE) membranes utilized in all‐solid‐state lithium batteries (ASLBs) have a high thickness (0.5–1.0 mm) and low ion conductance (<25 mS), which limit the cell‐level energy and power densities. Based on ethyl cellulose's unique amphipathic molecular structure, superior thermal stability, and excellent binding capability, this work fabricates a freestanding SE membrane with an ultralow thickness of 47 µm. With ethyl cellulose as an effective disperser and a binder, the Li6PS5Cl is uniformly dispersed in toluene and possesses superior film formability. In addition, an ultralow areal resistance of 4.32 Ω cm−2 and a remarkable ion conductance of 291 mS (one order higher than the state‐of‐the‐art sulfide SE membrane) are achieved. The ASLBs assembled with this SE membrane deliver cell‐level high gravimetric and volumetric energy densities of 175 Wh kg−1 and 675 Wh L−1, individually.

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Section: Introductionmentioning

confidence: 99%

Amphipathic Binder Integrating Ultrathin and Highly Ion‐Conductive Sulfide Membrane for Cell‐Level High‐Energy‐Density All‐Solid‐State Batteries

Cao

Sun

et al. 2021

Advanced Materials

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“…It is also soluble in ethanol and methanol yielding solutions with lower viscosity [ 13 ]. Moreover, because ethylcellulose is insoluble in water it is widely used for the controlled release of hydrophobic bioactive compounds [ 14 , 15 ]. Ethylcellulose is approved as a food additive in Europe (E462) [ 16 ], considered “Generally Recognised as Safe” GRAS and approved by the FDA (The United States Food and Drug Administration) as safe for human consumption [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Nanoparticles as a Carrier of β-Carotene: Production, Characterisation and In Vitro Gastrointestinal Digestion

et al. 2020

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β-carotene loaded bio-based nanoparticles (NPs) were produced by the solvent-displacement method using two polymers: zein and ethylcellulose. The production of NPs was optimised through an experimental design and characterised in terms of average size and polydispersity index. The processing conditions that allowed to obtain NPs (<100 nm) were used for β-carotene encapsulation. Then β-carotene loaded NPs were characterised in terms of zeta potential and encapsulation efficiency. Transmission electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction analysis were performed for further morphological and chemical characterisation. In the end, a static in vitro digestion following the INFOGEST protocol was performed and the bioaccessibility of β-carotene encapsulated in both NPs was determined. Results show that the best conditions for a size-controlled production with a narrow size distribution are lower polymer concentrations and higher antisolvent concentrations. The encapsulation of β-carotene in ethylcellulose NPs resulted in nanoparticles with a mean average size of 60 ± 9 nm and encapsulation efficiency of 74 ± 2%. β-carotene loaded zein-based NPs resulted in a mean size of 83 ± 8 nm and encapsulation efficiency of 93 ± 4%. Results obtained from the in vitro digestion showed that β-carotene bioaccessibility when encapsulated in zein NPs is 37 ± 1%, which is higher than the value of 8.3 ± 0.1% obtained for the ethylcellulose NPs.

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“…Ethyl cellulose is a linear, non-toxic, non-swellable polysaccharide [211] derivative of cellulose [149], it is insoluble in water and soluble in organic solvents, and has great mechanical properties [212]. It can be produced by Williamson etherification of cellulose and ethyl chloride.…”

Section: Ethyl Cellulosementioning

confidence: 99%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.

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Development of Ethyl Cellulose-based Formulations: A Perspective on the Novel Technical Methods

Cited by 56 publications

References 155 publications

Amphipathic Binder Integrating Ultrathin and Highly Ion‐Conductive Sulfide Membrane for Cell‐Level High‐Energy‐Density All‐Solid‐State Batteries

Amphipathic Binder Integrating Ultrathin and Highly Ion‐Conductive Sulfide Membrane for Cell‐Level High‐Energy‐Density All‐Solid‐State Batteries

Bio-Based Nanoparticles as a Carrier of β-Carotene: Production, Characterisation and In Vitro Gastrointestinal Digestion

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

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