Development of energy‐rich protein bars and in vitro determination of angiotensin I‐converting enzyme inhibitory antihypertensive activities

Jabeen, Sidra; Javed, Faiqa; Hettiarachchy, Navam; Sahar, Amna; Sameen, Aysha; Khan, Moazzam Rafiq; Siddeeg, Azhari; Riaz, Ayesha; Aadil, Rana Muhammad

doi:10.1002/fsn3.2756

Cited by 11 publications

(8 citation statements)

References 53 publications

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“…The composition, absorption, bioavailability, and taste of food depend on its ingredients. These ingredients can deliver functional attributes, but novel ingredients like plant seeds and fruit polyphenol extracts can provide much higher qualities [ 13 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Postprandial Antioxidative Response to Ingestion of Formulated Date- and Fruit-Based Nutritional Bars by Healthy Individuals

Alolyan,

Alfheeaid,

Alhowail

et al. 2024

Nutrients

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Nutritional bars (NBs) are gaining popularity among healthy and athletic individuals, but postprandial antioxidative response has not been investigated. Therefore, the current study examined the postprandial alterations in total phenolic content (TPC), total antioxidant capacity (T-AOC), malondialdehyde (MDA), and Superoxide dismutase (SOD) in the plasma of healthy individuals after the ingestion of 140 g (510 Kcal) from formulated date-based bars (DBBs) or fruit-based bars (FBBs). Firstly, the free and bound phenolic contents (PCs) were determined to be 10.15 and 12.98 and 6.19 and 3.57 mg GAE g−1, respectively. FBBs were significantly higher in free PC than DBBs, while DBBs were considerably higher in bound PC than FBBs. Secondly, twenty participants with age, height, weight, body mass index (BMI), fat mass, and fat-free mass averages of 21.4 years, 170.0 cm, 66.3 kg, 22.9 kg m2, 14.5, and 29.2 kg, respectively, were subjected to metabolic experiments (ISRCTN19386758). Ingestion of 140 g of FBB or DBB resulted in 288.50 or 302.14 µg TPC mL−1 blood, respectively. Postprandial TPC content increased with time progression and peaked after 120 min. T-AOC contents averaged 22.63 and 23.61 U mL−1 before ingestion of FBBs or DBBs, respectively. The T-AOC content increased significantly 120 and 180 min after ingestion of DBBs, while no significant change was noted after consuming FBBs. A significant decrease in MDA content was observed 180 min after consuming DBBs, while no significant change was noted after consuming FBBs. SOD concentrations ranged from 193.99 to 201.07 U L−1 in FBBs and DBBs, respectively. No considerable response was noted up to 3 h after ingestion of FBBs. On the contrary, a significant response was found 120 min after consuming DBBs. Pearson’s correlation coefficient indicated a highly significant positive correlation coefficient (p < 0.01) between T-AOC and either MDA or SOD, as well as between MDA and SOD. The principal component analysis demonstrated a strong and positive relationship between SOD and TPC at 60 and 120 min after DBB ingestion. In conclusion, the relative changes in postprandial responses in T-AOC and MDA did not significantly (p > 0.05) differ between DBBs and FBBs, except for TPC (p = 0.04, paired t-test) and SOD (p = 0.003, paired t-test). Further studies with an extended experimental time are needed to confirm the current findings.

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Section: Discussionmentioning

confidence: 99%

Postprandial Antioxidative Response to Ingestion of Formulated Date- and Fruit-Based Nutritional Bars by Healthy Individuals

Alolyan,

Alfheeaid,

Alhowail

et al. 2024

Nutrients

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“…The Citrus fruit peels inhibit the activity of ACE In-vitro was measured according to the spectrophotometric method of [27][28][29][30] . Briefly, 50μl of Orange, Kinnow, and Mosambi autolysate and150 μl of hippuryl-L-histidyl-L-leucine (HHL, 12.5 mM in 0.010 M sodium borate buffer containing NaCl 0.4 M, pH 8.3) were incubated at 37°C for 5 min.…”

Section: Angiotensin-converting Enzyme Inhibition Assaymentioning

confidence: 99%

Untitled

2023

IJPSR

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Orange (Citrus sinensis), Kinnow (Citrus reticuleta), and Mosambi (Citrus limetta) methanolic, the aqueous extract showed the inhibitory activity on α-amylase and α-glucosidase assay where methanolic, acetone and aqueous extract of these fruit peels exhibited the anti-hypertensive activities. The results showed that the methanol and aqueous extract of Orange, Kinnow, and Mosambi peels inhibited αamylase and α-glucosidase activities. However, Orange peels (IC 50 = 18.4 and 9.43 µg/mL) and Kinnow peels (IC 50 = 12.6 and 6.09 µg/mL) exhibited higher capacity to inhibit α-amylase activity compared to Mosambi peels (IC 50 = 11.6 and 6.54 µg/mL) and Orange peels (IC 50 =12.5 and 8.67 µg/mL) methanol and aqueous extract exhibited higher inhibitory effects on α-glucosidase activity compared to Kin now (IC50= 9.78 and 7.65 µg/mL) and Mosambi peel (IC 50 =4.56 and 10.6 µg/mL).respectively. Similarly, methanol, acetone, and aqueous extract of Orange, Kin now and Mosambi inhibit the angiotensin-1-converting enzyme (ACE) activity. Moreover, methanol and acetone extract of Orange (IC 50 =0.38 and 0.40 ug /mL) and Mosambi (IC 50 = 0.44 and 0.46ug /mL) showed significant inhibitory capacity on ACE and aqueous extract of Orange (IC 50 = 0.42 ug /mL), Kinnow (IC 50 = 0.45 ug /mL) and Mosambi (IC 50 = 0.48 ug /mL) showed significant inhibitory capacity on ACE. The study found that methanol and aqueous extract of Orange, Kinnow, and Mosambi peels showed great potential for anti-diabetic and methanol, acetone, and aqueous peels extract anti-hypertensive activities. Moreover, methanol and aqueous extract of Orange peels were more potent than Kinnow and Mosambi peels. INTRODUCTION:Citrus fruit is an important medicinal plant that belongs to the Rutaceae family. These are the most popular fruits worldwide due to their delicious taste and pleasant QUICK RESPONSE CODE

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“…In a similar formulation of date bars, Munir et al (2018) utilized roasted oatmeal flour, chickpea flour, skimmed milk powder, almonds, pistachios, cardamom, and carboxymethyl cellulose (CBC). Recently, cheddar cheese and whey protein isolate were tried with roasted chickpea flour, rice flour, and dried apricots (Jabeen et al, 2020(Jabeen et al, , 2022. Adding healthful components improves date bars.…”

Section: Introductionmentioning

confidence: 99%

The organoleptic and nutritional characteristics of innovative high-fiber khalas date-based bar

Barakat,

S.M. Almutairi

2024

Ital. J. Food Sci.

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Making functional and nutritionally balanced date bars is of innovative concern. The current study intends to create a novel high-fiber and nutritious Khalas date-based bar (KDBB). The proximate composition, mineral contents, sugar profile, amino and fatty acids profile, volatiles and phytochemicals, antioxidant activity, and an in vitro digestion of protein and carbohydrates for bar formula containing 50% Khalas dates (KD) were investigated. Results indicated that protein, fat, ash, fiber, available carbohydrates, and vitamin C were 9.34, 4.93, 2.05, 8.01, 54.04 g 100 g-1, and 16.67 mg, respectively. Potassium, magnesium, phosphorus, and calcium were present in abundance. Sucrose had the highest sugar concentration at 246.35 mg g-1. Total phenolic content (TPC) was 547.19 mg gallic acid equivalent 100 g-1, giving 719.39 and 815.98 µmol of Trolox equivalent (TE) 100 g-1 for 2,2-diphenylpicrylhy-drazyl radical scavenging activity (DPPH-RSA) and 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)-RSA, respectively. Total carotenoids, flavonoids, and flavonols were 327.19 mg 100 g-1, 998.25 mg quercetin equivalent 100 g-1, and 749.57 mg QE 100 g-1, respectively. The highest discovered phenolics, flavonoids, and isoflavone were pyrocatechol (10249.73 μg g-1), catechin (193.50 μg g-1), and daidzein (18.77 μg g-1), respectively. Lysine was the highest among the essential amino acids. Saturated and unsaturated fatty acids were 43.73% and 56.27%, respectively. The omega-6 fatty acid, cis-8,11,14-eicosatrienoic, was predominant with a 31.08% valuation. The gas chromatography–mass spectrometry analysis identified 17 compounds, with a predominant presence of 9,12-octadecadienoyl chloride (38.13 g 100 g-1). The glycemic index (GI) of KDBB was 39.97, which was lower than KD’s score (54.12). In conclusion, prepared KDBB could present a good idea for consuming dates and the based products with high fiber content and lower GI. Scaling up such products could be helpful to health-conscious individuals.

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Development of energy‐rich protein bars and in vitro determination of angiotensin I‐converting enzyme inhibitory antihypertensive activities

Cited by 11 publications

References 53 publications

Postprandial Antioxidative Response to Ingestion of Formulated Date- and Fruit-Based Nutritional Bars by Healthy Individuals

Postprandial Antioxidative Response to Ingestion of Formulated Date- and Fruit-Based Nutritional Bars by Healthy Individuals

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The organoleptic and nutritional characteristics of innovative high-fiber khalas date-based bar

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