Development of encapsulation technique for curcumin loaded O/W emulsion using chitosan based cryotropic gelation

Encapsulation of Curcumin Loaded Oil Droplets with Chitosan Based Cryogel: Influence of Freezing Condition on Nanocapsule Properties

“…Effect of the post-freezing incubation on swelling and the yields of gel fraction and encapsulation Sowasod et al (2012) reported that the slower the cooling rate, the bigger the swelling ratio of freeze-dried cryogels, and surprisingly this phenomenon was essentially independent of the introduced oil phase composition. Generally, a bigger swelling ratio means that the microstructure of the cryogel matrix has fewer cross-links and less bonding strength.…”

“…On the other hand, curcumin shows low bioavailability inside the human body because of its low intrinsic activity and poor absorption, and these shortcomings have retarded development of new curcumin formulations. We have successfully prepared a cryogel system based on chitosan-carrageenan-carboxymethylcellulose (CMC) for the encapsulation of an oil phase (Sowasod et al, 2012) by selecting their proper composition and freezing condition. In order to induce gelation on the surface of oil droplets, the ternary system was designed to induce gelation through freezing, that is, cryotropic gelation.…”

Development and Validation of an HPLC Method Using Fluorescence Detection for the Quantitative Determination of Curcumin in PLGA and PLGA-PEG Nanoparticles

“…But in this method the run time for analysis was 27 min. A recent work of Sowasod et al (2012) [43] relates the development of a hydrogel containing curcumin and used an HPLC-UV method to determine the curcumin encapsulation yield measurement. The mobile phase consisted of a mixture of acetonitrile and 10% acetic acid in water (50:50, v/v) at a Also has been observed that in the most studies using HPLC-UV/Vis detection the authors only cites the chromatographic parameters and does not give any information about the method validation and even the retention time of curcumin.…”

Characteristics of eugenol loaded chitosan-tripolyphosphate particles as affected by initial content of eugenol and their in-vitro release characteristic

“…The clumping of particles occured due to effect of centrifugation and freeze drying which cause the agglomerated particles. The freeze drying results of the colloidal suspension produce a porous surface, the pores being generated from water crystals formed during freezing, which are subsequently removed by sublimation [11]. The surface morphology of the eugenol-loaded particles, at 1000 x magnification was rough and more pores and hollow form than the chitosan-TPP.…”