Development of Electrospun Three‐arm Star Poly(<i>ε</i>‐caprolactone) Meshes for Tissue Engineering Applications

Puppi, Dario; Detta, Nicola; Piras, Anna Maria; Chiellini, Federica; Clarke, Dave; Reilly, Gwendolen C.; Chiellini, Emo

doi:10.1002/mabi.200900422

Cited by 44 publications

(37 citation statements)

References 73 publications

(122 reference statements)

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“…In fiber form, PCL and its copolymers have been investigated as drug delivery systems, ‘long‐lasting’ absorbable sutures, and 3‐D scaffolds for tissue engineering applications . Extrusion of PCL into monofilaments and multifilaments may be achieved by fiber formation mechanisms, such as melt spinning, electrospinning, and solution spinning . There are distinct features of each of these processes that are subsequently reflected in fiber properties.…”

Section: Introductionmentioning

confidence: 99%

Application of response surface methodology to evaluate the effect of dry‐spinning parameters on poly (ε‐caprolactone) fiber properties

Azimi

Nourpanah

Rabiee

et al. 2015

J of Applied Polymer Sci

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Poly (e-caprolactone) fibers were prepared by dry-spinning method. The effect of processing parameters on linear density, mechanical, and morphological properties of fibers was investigated using the response surface methodology (RSM). This method allowed evaluating a quantitative relationship between polymer concentrations, spinning speed, and draw ratio on the properties of the fibers. Polynomial regression model was fitted to the experimental data to generate predicted response. The results were subjected to analysis of variance to determine significant parameters. It was found that all three parameters had significant effect on linear density of fibers. Combined effect of concentration and spinning speed was observed in which the linear density of fiber was more sensitive to changes in the solution concentration at lower spinning speed. Polymer concentration had the largest influence on the mechanical properties of fibers. An average cross-sectional radius of fibers was affected by concentration and draw ratio in opposite manner. Among all three parameters, only polymer concentration had significant effect on circularity of fiber cross sections. By applying the RSM, it was possible to obtain a mathematical model that can be used to better define processing parameters to fabricate dry-spun PCL fiber in a more rational manner.

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Section: Introductionmentioning

confidence: 99%

Application of response surface methodology to evaluate the effect of dry‐spinning parameters on poly (ε‐caprolactone) fiber properties

Azimi

Nourpanah

Rabiee

et al. 2015

J of Applied Polymer Sci

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“…Several polymeric materials and processing methodologies have been investigated for the development of scaffolds with different architecture [1,2,3]. In particular, 3D networks of polymeric structural elements of different geometry and size, such as fibers or filaments with a diameter in the micro and nanoscale, have been proposed as suitable scaffolds due to their high and interconnected porosity as well as high surface area to volume ratio that can promote the adhesion and migration of cells, and the mass transport phenomena associated with cellular activity and material degradation [4,5,6,7,8]. …”

Section: Introductionmentioning

confidence: 99%

Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering

et al. 2011

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This research activity was aimed at the development of dual-scale scaffolds consisting of three-dimensional constructs of aligned poly(ε-caprolactone) (PCL) microfilaments and electrospun poly(lactic-co-glycolic acid) (PLGA) fibers. PCL constructs composed by layers of parallel microsized filaments (0/90° lay-down pattern), with a diameter of around 365 μm and interfilament distance of around 191 μm, were produced using a melt extrusion-based additive manufacturing technique. PLGA electrospun fibers with a diameter of around 1 μm were collected on top of the PCL constructs with different thicknesses, showing a certain degree of alignment. Cell culture experiments employing the MC3T3 murine preosteoblast cell line showed good cell viability and adhesion on the dual-scale scaffolds. In particular, the influence of electrospun fibers on cell morphology and behavior was evident, as well as in creating a structural bridging for cell colonization in the interfilament gap.

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“…Hence, aliphatic polyesters are widely used to prepare polyurethane [1,2], elastomers [3], drug delivery materials [4,5] and scaffold for tissue engineering [6,7]. Among these, poly(ε-caprolactone) is of great interest due to that εCL is commercially available, biocompatible and readily polymerizable.…”

Section: Introductionmentioning

confidence: 99%

Organocatalyzed ring-opening copolymerization of α-bromo-γ-butyrolactone with ε-caprolactone for the synthesis of functional aliphatic polyesters – pre-polymers for graft copolymerization

Gao

Tsou

Zeng

et al. 2018

Designed Monomers and Polymers

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Diphenyl phosphate (DPP) was exploited as an organocatalyst to synthesize copolymers by ring-opening polymerization with α-bromo-γ-butyrolactone (αBrγBL) and ε-caprolactone (εCL) as monomers and polyethylene glycol (PEG) as initiator. The conversion rates of monomers and molecular weights of copolymers synthesized under different conditions were determined by 1H-NMR. The 1H-NMR results showed that the copolymers of αBrγBL and εCL initiated by PEG (PEGCB) were successfully synthesized and the conversions of εCL were relatively high (＞70%), while the conversions of αBrγBL were relatively low (＜26%). The highest molar ratio of αBrγBL to εCL units in these copolymers is 0.17, when the copolymerization was carried out at 100℃ for 17h.The bromine atoms hanged on the chain of the copolymers PEGCB provide a good opportunity to construct graft copolymers via atom transfer radical polymerization (ATRP). The subsequent grafting of 2-(dimethylamino)ethyl methacrylate (DMAEMA) was conducted by using PEGCB3 as macroinitiator, CuBr/N,N’,N’,N”,N”- pentamethyldiethylenetriamine (PMDETA) as catalysts and toluene/anisole as solvents via ATRP. According to the analysis of 1H-NMR, the grafting efficiency, grafting ratio and grafting frequency were 22.4%, 160.7% and 1133.8, respectively.

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Development of Electrospun Three‐arm Star Poly(ε‐caprolactone) Meshes for Tissue Engineering Applications

Cited by 44 publications

References 73 publications

Application of response surface methodology to evaluate the effect of dry‐spinning parameters on poly (ε‐caprolactone) fiber properties

Application of response surface methodology to evaluate the effect of dry‐spinning parameters on poly (ε‐caprolactone) fiber properties

Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering

Organocatalyzed ring-opening copolymerization of α-bromo-γ-butyrolactone with ε-caprolactone for the synthesis of functional aliphatic polyesters – pre-polymers for graft copolymerization

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