Development of Early Diagnosis of Parkinson’s Disease Using Premotor Symptoms and Blood Changes as Biomarkers

Гусев, Е. И.; Katunina, E A; Martinov, M. Yu.; Блохин, В. Е.; Калинкин, А. Л.; Alesenko, A. V.; Nodel, M. R.; Малыхина, Е. А.; Titova, Nataliya; Katunin, D.A.; Shupik, M. A.; Gutner, U. A.; Maloshitskaya, O. A.; Sokolov, Sergey; Kucheryanu, V. G.; Pavlova, Ekaterina; Ugrumov, M. V.

doi:10.1007/s11055-021-01164-5

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…This study showed for the rst time that PD patients had increased expression of SM in CSF, including SM (d18:1/20:1), SM (d18:2/14:0), SM (d18:0/16:0) and SM (d18:2/24:1). In another study, SM (d18:1/20:1) was found to have increased expression in serum from PD patients but not the whole SM family 40 . It was supposed that SM in CSF does not have a strong enough in uence to change its concentration in serum.…”

Section: Discussionmentioning

confidence: 90%

Lipid metabolism disorder in cerebrospinal fluid related to Parkinson’s disease

Qiu

Tang

et al. 2022

Preprint

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Background: Abnormal accumulation of lipids is found in dopamine neurons and resident microglia in the substantia nigra of patients with Parkinson’s disease (PD). The accumulation of lipids is an important risk factor for PD. Previous studies havemainly focused on lipid metabolism in peripheral blood, but little attention has been givento cerebrospinal fluid (CSF). Objective: We drew the lipidomic signature in CSF from PD patients and evaluated the role of lipids in CSF as biomarkers for PD diagnosis. Methods: Based on lipidomic approaches, we investigated and compared lipid metabolism in CSF from PD patients and healthy controls without dyslipidaemia in peripheral blood and explored the relationship of lipids between CSF and serum by Pearson correlation analysis. Results: A total of 231 lipid species were detected and classified into 13 families in the CSF. The lipid families, including phosphatidylcholine (PC), sphingomyelinase (SM) and cholesterol ester (CE), had significantly increased expressioncompared withthecontrol. Hierarchical clustering was performed to distinguish PD patients based on the significantly changed expression of 37 lipid species. Unsupervisedand supervised methods were used to refine this classification. A total of 12 lipid species, including 3-hydroxy-dodecanoyl-carnitine, PC (O-18:3/20:3), PC (O-20:2/24:3), PC (14:0/18:2), PC (O-18:3/20:2), Cer (d18:1/24:1), CE (22:6), CE (20:4), SM (d18:1/20:1), SM (d18:2/14:0), SM (d18:0/16:0) and SM (d18:2/24:1), were selected to draw the lipidomic signature of PD. Correlation analysis was performed and showed that the CE family and CE (22:6) in CSF had a positive association with TC in the peripheral blood from PD patientsbut not from healthy controls. Conclusions Our results revealed that thelipidomic signature in CSF may be considered a potential biomarker for PD diagnosis, and increased CE, PC and SM in CSF may reveal pathological changes,such as blood‒brainbarrier leakage,in the brainsof PD patients.

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Section: Discussionmentioning

confidence: 90%

Lipid metabolism disorder in cerebrospinal fluid related to Parkinson’s disease

Qiu

Tang

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Lipid Metabolism Disorder in Cerebrospinal Fluid Related to Parkinson’s Disease

Qiu

Wei

et al. 2023

Brain Sciences

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Background: Abnormal accumulation of lipids is found in dopamine neurons and resident microglia in the substantia nigra of patients with Parkinson’s disease (PD). The accumulation of lipids is an important risk factor for PD. Previous studies have mainly focussed on lipid metabolism in peripheral blood, but little attention has been given to cerebrospinal fluid (CSF). We drew the lipidomic signature in CSF from PD patients and evaluated the role of lipids in CSF as biomarkers for PD diagnosis. Methods: Based on lipidomic approaches, we investigated and compared lipid metabolism in CSF from PD patients and healthy controls without dyslipidaemia in peripheral blood and explored the relationship of lipids between CSF and serum by Pearson correlation analysis. Results: A total of 231 lipid species were detected and classified into 13 families in the CSF. The lipid families, including phosphatidylcholine (PC), sphingomyelin (SM) and cholesterol ester (CE), had significantly increased expression compared with the control. Hierarchical clustering was performed to distinguish PD patients based on the significantly changed expression of 34 lipid species. Unsupervised and supervised methods were used to refine this classification. A total of 12 lipid species, including 3-hydroxy-dodecanoyl-carnitine, Cer(d18:1/24:1), CE(20:4), CE(22:6), PC(14:0/18:2), PC(O-18:3/20:2), PC(O-20:2/24:3), SM(d18:0/16:0), SM(d18:2/14:0), SM(d18:2/24:1), SM(d18:1/20:1) and SM(d18:1/12:0), were selected to draw the lipidomic signature of PD. Correlation analysis was performed and showed that the CE family and CE (22:6) in CSF had a positive association with total cholesterol in the peripheral blood from PD patients but not from healthy controls. Conclusions: Our results revealed that the lipidomic signature in CSF may be considered a potential biomarker for PD diagnosis, and increased CE, PC and SM in CSF may reveal pathological changes in PD patients, such as blood–brain barrier leakage.

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Development of Early Diagnosis of Parkinson’s Disease Using Premotor Symptoms and Blood Changes as Biomarkers

Cited by 2 publications

References 51 publications

Lipid metabolism disorder in cerebrospinal fluid related to Parkinson’s disease

Lipid metabolism disorder in cerebrospinal fluid related to Parkinson’s disease

Lipid Metabolism Disorder in Cerebrospinal Fluid Related to Parkinson’s Disease

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