Development of dietary fiber psyllium based hydrogel for use in drug delivery applications

Singh, Baljit; Sharma, Vikrant; Kumar, Rajender; Mohan, Man

doi:10.1016/j.fhfh.2022.100059

Cited by 9 publications

(7 citation statements)

References 42 publications

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“…along with C=O stretching of galacturonic acid (Fig. 3) (Singh et al, 2022;Singh b et al, 2007). Psyllium with its -OH stretching group has been prominently witnessed to form more hydrogen bond associations with its probability to form less and wider intense band (Zhang et al, 2021).…”

Section: Plausible Mechanism For Grafting Uranium Ion Uptake and Dye ...mentioning

confidence: 99%

Synergistic effect of bio-inspired Psyllium/Okra hybrid backbone based hydrogel using RSM optimization for efficient removal of toxic malachite green dye and sequestration of uranium (VI) ions from water

Singh

Kaith

Mehra

et al. 2022

Preprint

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The objective of the present work is to fabricate environment-friendly biosorbent semi-Interpenetrating Network Device based on Psyllium-Okra hybrid backbone and acrylamide by using citric acid and ammonium persulphate as the crosslinker and initiator respectively. Response Surface Methodology (RSM) was used for the optimization of different reaction parameters that sequentially maximized the percentage swelling of the fabricated gel. Amalgamation of acrylamide chains onto Psyllium-Okra based hybrid backbone functional groups present and crosslinking between the different polymeric chains were further confirmed through techniques like FTIR, SEM-EDX and PXRD. The sample showed better thermal stability with decomposition of different phases at higher temperatures. The synthesized semi-IPN was successfully proved to be the proficient candidate for the removal of cationic toxic malachite green dye (62.38 %) with an adsorbent dose of 1.0 g, initial concentration of 10 mg L-1 and time interval of five minute at ambient temperature. Langmuir and Freundlich adsorption isotherm models were studied in order to determine the nature of adsorption took place and it was analysed that Langmuir adsorption isotherm was the best fit model for the removal of toxic cationic malachite green dye. Kinetic studies for the sorption of dyes favoured the reaction mechanism to occur via a pseudo second order pathway with R2 value about 0.99. The synthesized semi-IPN was also utilized in uranium (VI) uptake with an adsorbent dose of 1.0 g, initial concentration of 100 ppb, time interval of 55 minutes at room temperature. The semi-IPN could uptake 97.10 ppb uranium (VI) and was observed highly efficient in uranium (VI) ions removal from aqueous medium. Thus, adsorption studies indicated that semi-IPN prepared out of natural blend was found effective in the sequestration of toxic dyes and heavy metal ions.

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Section: Plausible Mechanism For Grafting Uranium Ion Uptake and Dye ...mentioning

confidence: 99%

Synergistic effect of bio-inspired Psyllium/Okra hybrid backbone based hydrogel using RSM optimization for efficient removal of toxic malachite green dye and sequestration of uranium (VI) ions from water

Singh

Kaith

Mehra

et al. 2022

Preprint

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“…Psyllium husk is the main source of arabinoxylan (Li, Q., Wang, S., Jin, X., Huang, C., & Xiang, Z., 2020) and is of laxative nature so used for the treatment of constipation and diarrhoea due to its water-solubility and gel-forming capacity. Psyllium-based polymeric materials and hydrogels have been reported for various therapeutic and pharmaceutical applications like cholesterol reduction (Uehleke, B., Ortiz, M., & Stange, R., 2008), wound dressing (Ahmad, N., et al , 2021), drug delivery (Singh, B., Sharma, et al, 2022, Kotta, S., et al,2022 tissue regeneration (Poddar, S., et al, 2021), cancer treatment (Kumar, D., Gautam, A., & Kundu, P. P., 2022, Masood, R., & Miraftab, M., 2010) lower normal LDL level (Jovanovski, E., et al, 2018, Everson, G. T., et al, 1992 and Industrial applications like treating of coloured effluents from water (Druzian, S. P., 2021), wastewater treatment (Das, N., Ojha, N., & Mandal, S. K., 2021, Singh, J., Kumar, S., & Sharma, S. 2022) such as removal of Hg(II) from the solution (Kumar, D., Pandey, J., Khan, N., Kumar, P., & Kundu, P. P. 2019) to mention a few. The hydrophilic nature of the psyllium husk imparting its excellent swell ability is one of the defining properties for its varied applications (Singh, B., Chauhan, G. S., Bhatt, S. S., & Kumar, K. (2006), Singh, B., Sharma, N., & Chauhan, N. (2007, Singh, B., & Chauhan, N., 2009).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterisation and Comparative Study of Hydrogel and Nanogels of Psyllium

Kumar

Dharela

Chauhan

2023

Am. J. Innov. Sci. Eng.

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Natural polysaccharides are being explored as the matrices for attaining speciality materials for pharmaceutical, medicinal and environmental applications via chemical modification such as grafting. Psyllium polysaccharide-based hydrogels and nanogels have potential biomedical and water purification applications due to their advantageous properties such as stimulus responsiveness, biocompatibility, target drug delivery and stability. The present study aims to synthesise hydrogel and nanogels of psyllium and attain comparative data for the two to undermine their potential applications. Psyllium– cl –N,N–MBAm–poly(AAm) hydrogel (Psy-MBAm-AAm – hg) and Psyllium– cl –N,N–MBAm–poly(AAm) nanogel (Psy-MBAm-AAm – ng) were synthesised by grafting acrylamide (AAm) onto psyllium using ammonium persulphate (APS) as a free radical initiator in a redox system where N, N-methylene bisacrylamide acted as a crosslinker. The comparative study of synthesised gels was carried out by studying swelling characteristics at acidic and basic pH (7 and 4) and at varied temperatures for both matrices. The synthesised hydrogel and nanogels were subjected to characterisation by Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), and Zeta Potential Analysis to get evidence for successful synthesis and nanogel formation.

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“…The encapsulation of the active compound and its release from the polymer have been influenced by the porosity and cross-linking density of the hydrogel, which could be modified by changing the composition and cross-linking of the CDD. 4 Aouada and coworkers 5 prepared cellulose−polyacrylamide CDDs for the pesticide paraquat, and they observed a declined release with an increased cellulose content in the formulation, ascribing it to the increased network density of the polymer chains. They also observed a sustained release of the pesticide from the 15th to 46th day, which was attributed to the composition of formulation that modified the diffusion mechanism of the pesticide from the formulations.…”

Section: Introductionmentioning

confidence: 99%

“…The release of agrochemicals from the polymer-based CDD delivers the chemical slowly. The encapsulation of the active compound and its release from the polymer have been influenced by the porosity and cross-linking density of the hydrogel, which could be modified by changing the composition and cross-linking of the CDD . Aouada and co-workers prepared cellulose–polyacrylamide CDDs for the pesticide paraquat, and they observed a declined release with an increased cellulose content in the formulation, ascribing it to the increased network density of the polymer chains.…”

Section: Introductionmentioning

confidence: 99%

Designing Starch–Alginate Hydrogels for Controlled Delivery of Fungicide for the Alleviation of Environmental Pollution

Singh

Vishavnath

2022

ACS Agric. Sci. Technol.

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In this work, a controlled delivery system for the fungicide thiophanate-methyl (TM) was developed for the alleviation of environmental pollution using starch–alginate–polyacrylamide hydrogels as a sustainable agricultural development approach. The polymer hydrogel was synthesized by grafting poly(acrylamide) onto starch–alginate using N,N-methylenebisacrylamide (NNMBA) as the cross-linker. The copolymers were confirmed by characterization techniques including scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared analysis, X-ray diffraction, 13C NMR, TGA-DTG, and differential scanning calorimetry. SEM confirmed the heterogeneity, and AFM showed the rough surface morphology of the copolymeric hydrogels. The thermogravimetric analysis results indicated the increase in the thermal stability of the cross-linked polymers after modification. Evaluation was carried out on the water absorption capacity of the polymer and the release of the encapsulated fungicide. The swelling of the hydrogel decreased with the increment in cross-linking density with a rise in [NNMBA]. It also influenced the diffusion of the fungicide from the encapsulated copolymer, wherein the increase in the cross-linker content decreased the fungicide release from the copolymer. Hydrogels absorbed 18.30 ± 1.40 (g/g of gel) water, indicating the water retention capacity of the hydrogel material which could be useful for plant growth in the arid regions. The release profile followed the non-Fickian diffusion mechanism with a sustained delivery of TM. Water retention and the controlled release properties of the hydrogel indicated its usefulness in sustainable agricultural development and alleviation of environmental pollution caused by the fungicide use. Overall, the formation of a controlled pesticide delivery system based on natural polysaccharides with polyacrylamide-based hydrogels which act as nutrients for plants on degradation is a unique approach, implying that the slow release of the pesticide will reduce environmental pollution and pesticide cost.

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Development of dietary fiber psyllium based hydrogel for use in drug delivery applications

Cited by 9 publications

References 42 publications

Synergistic effect of bio-inspired Psyllium/Okra hybrid backbone based hydrogel using RSM optimization for efficient removal of toxic malachite green dye and sequestration of uranium (VI) ions from water

Synergistic effect of bio-inspired Psyllium/Okra hybrid backbone based hydrogel using RSM optimization for efficient removal of toxic malachite green dye and sequestration of uranium (VI) ions from water

Synthesis, Characterisation and Comparative Study of Hydrogel and Nanogels of Psyllium

Designing Starch–Alginate Hydrogels for Controlled Delivery of Fungicide for the Alleviation of Environmental Pollution

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