Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
Rohan Eapen,
Cynthia Okoye,
Christopher Stubbs
et al.
Abstract:E3 ubiquitin ligases engage their substrates via 'degrons' - short linear motifs typically located within intrinsically disordered regions of substrates. As these enzymes are large, multi-subunit complexes that generally lack natural small-molecule ligands and are hard to drug via conventional means, alternative strategies are needed to target them in diseases, and peptide-based inhibitors derived from degrons represent a promising approach. Here we explore peptide inhibitors of Cdc20, a substrate-recognition … Show more
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