Development of cytocompatible antibacterial electro-spun nanofibrous composites

Abstract

This study presents a method of producing biocompatible nanofibrous composites containing antimicrobial polymers which have excellent antimicrobial efficacy. Specifically, antimicrobial cellulose acetate (CA) nanofibrous composites were prepared by adding poly[5,5-dimethyl-3-(3 0 -triethoxysilylpropyl)hydantoin] (PBA) to the CA solution using the electro-spinning technique followed with curing and exposure to diluted sodium hypochlorite.Scanning electron microscopy images demonstrated that CA nanofibers formed with diameters of 172 ± 62 nm. The chlorinated CA nanofibrous mats showed good UVA stability. The chlorinated CA nanofibrous mats completely inactivated Staphylococcus aureus (gram-positive) and Escherichia coli O157:H7 (gramnegative) within 30 min of contact time. The cell culture assay showed that the N-halamine-modified CA nanofibrous composites are non-toxic in vitro.

Antibacterial functionalization of cotton fabrics by electric‐beam irradiation

“…The chlorine contents of the cotton fibers grafted with TMPA (cotton–IP–Cl) and TMPA/AA were 0.11 and 0.03%, respectively, and their graft yields were 9.3 and 3.2%, respectively. The reason for the lower chlorine content of the cotton grafted with TMPA/AA was that the initiated AA aggregated easily, and the poly(acrylic acid) prevented the monomers from grafting onto the cotton fibers in the extended time reaction.…”

“…Recently, polymeric antibacterial N ‐halamines, such as poly[1,3‐dichloro‐5‐methyl‐(4′‐vinyl phenyl) hydantoin], have been synthesized and have been shown to have good antibacterial efficacy . N ‐Halamine polymers might be superior to other antibacterial polymers, such as polymeric phosphonium materials and polymeric quaternary ammonium compounds, in terms of their antibacterial efficacy, stability, rechargeability, and lack of toxicity . To bond the polymeric antibacterial agents to existing polymeric backbones, both conventional chemical grafting techniques and radiation grafting methods have been used.…”

“…27 N-Halamine polymers might be superior to other antibacterial polymers, such as polymeric phosphonium materials and polymeric quaternary ammonium compounds, in terms of their antibacterial efficacy, stability, rechargeability, and lack of toxicity. 1,[28][29][30] To bond the polymeric antibacterial agents to existing polymeric backbones, both conventional chemical grafting techniques and radiation grafting methods have been used. Radiation grafting has some advantages over conventional chemical grafting methods in the modification of fibers.…”

Concentration- and roughness-dependent antibacterial and antifungal activities of CuO thin films and their Cu ion cytotoxicity and elution behavior

“…The antimicrobial activities of Cu ions are proportionate to their concentration and surface roughness, because these factors increase the contact surface between Cu ions and microbes. Therefore, the use of Cu ions as an antimicrobial coating method has been investigated in several studies [11,[17][18][19][20].Abstract In this study, we aimed to evaluate the antibacterial and antifungal properties, cytotoxicity, and elution behavior of copper oxide (CuO) thin films with varying concentrations and roughness values. CuO films greater than 0.2 mol % showed 99.9 % antimicrobial activity against Escherichia coli, Staphylococcus aureus, Campylobacter jejuni, and Penicillium funiculosum.…”

“…The antimicrobial activities of Cu ions are proportionate to their concentration and surface roughness, because these factors increase the contact surface between Cu ions and microbes. Therefore, the use of Cu ions as an antimicrobial coating method has been investigated in several studies [11,[17][18][19][20].…”