Development of cyclopentadienyl tricarbonyl metal complexes as radiopharmaceuticals for the estrogen receptor using an “integrated” design

Abstract

The need for imaging agents for estrogen receptor positive (ER+) tumors that are both cost effective and widely available has prompted us to search for cyclopentadienyl tricarbonyl metal (CpTM, M=Mn, Tc, Re) complexes that bind well to the ER. The nuclide Tc-99m is known for its convenient 6hr half-life and benchtop