Development of Cutaneous Sensory Receptors Birds

Saxod, Raymond

doi:10.1007/978-3-642-66880-7_8

Cited by 46 publications

(53 citation statements)

References 119 publications

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“…Furthermore, at least for sensory corpuscles, there was an apparent colocalization of p75 and TrkA immunoreactivities. The occurrence of low-affinity neurotrophin receptors in sensory corpuscles is not surprising because of the origin (Saxod, 1978(Saxod, , 1996Halata et al, 1990) and relationship of corpuscular constituents with nerve fibers. The lamellar cells of Meissner corpuscles and the inner core originate from the neural crest and are regarded as Schwannrelated cells; the outer core and the capsule of Pacinian corpuscles originate from the perineurium.…”

Section: Nerves and Sensory Corpusclesmentioning

confidence: 99%

p75 and TrkA neurotrophin receptors in human skin after spinal cord and peripheral nerve injury, with special reference to sensory corpuscles

et al. 1998

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Human skin, including nerves and sensory corpuscles, displays immunoreactivity (IR) for low-(p75) and high-affinity (TrkA-like) receptors for nerve growth factor (NGF), the best characterized member of the family of neurotrophins. This study was designed to analyze the changes induced by spinal cord and peripheral nerve injuries in the expression of neurotrophin receptors in digital skin, with special reference to nerves and sensory corpuscles.Skin biopsy samples were obtained from 1) the hand and toes of normal subjects, 2) below the level of the lesion of patients with spinal cord injury affecting dorsal and lateral funiculi, 3) the cutaneous territory of entrapped peripheral nerves (median and ulnar nerves), and 4) the cutaneous territory of sectioned and grafted nerves (median nerve). The pieces were formalinfixed and paraffin-embedded, cut in serial sections, and processed for immunohistochemistry using antibodies against human p75 and TrkA proteins. The percentage of sensory corpuscles displaying IR for p75 and TrkA-like, as well as the intensity of IR developed within them, was assessed using quantitative image analysis.Spinal cord severance causes a decrease in p75 IR in Meissner and Pacinian corpuscles, whereas TrkA-like IR did not vary. In other nonnervous tissues (i.e., epidermis, sweat glands), both p75 and TrkA-like IR was diminished or even absent. Similar but more severe changes were encountered in the skin from the territory of entrapped nerves. Finally, in subjects with sectioned-grafted nerves, p75 IR was found close to controls in nerves, reduced in Meissner corpuscles, and absent in the inner core of the Pacinian ones; TrkA-like IR was in the perineurium, a small percentage of Meissner corpuscles (about 7%), and the outer core and capsule of the Pacinan corpuscles. In the nonnervous tissues, p75 IR was practically absent, whereas TrkA-like IR did not change. No changes in the expression of neurotrophin receptors were observed in Merkel cells of the different groups.Present results show the following: 1) expression of nerve p75 IR in human cutaneous sensory corpuscles is sensitive to central deafferentation, to blockade or difficulty in axonal transport, and to disruption of axonal

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Section: Nerves and Sensory Corpusclesmentioning

confidence: 99%

p75 and TrkA neurotrophin receptors in human skin after spinal cord and peripheral nerve injury, with special reference to sensory corpuscles

et al. 1998

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“…Intervening basal lamina or collagen fibrils between the individual lamellae have been observed in Meissner corpuscles (IDE, 1976), Krause simple Endkolben , Pacinian corpuscles (CHOUCxxov, 1978), genital end bulbs (MUNGER, 1971), and lamellated receptors of frog skin (DURING and SEILER, 1974). It has been reported that the interlamellar space of the Herbst corpuscle contains collagen fibrils, but not basal lamina (ANDERSEN and NAFSTAD , 1968;SAXOD, 1978). The lamellar cells in the mechanoreceptors described above were thought to have been derived from the Schwann cell (HALATA , 1975;IDE, 1977;SAXOD, 1978).…”

Section: Discussionmentioning

confidence: 96%

“…1968;HALATA, 1971;SAXOD, 1978;CHOUCnxov, 1978), Meissner corpuscles (IDE , 1976, Krause simple Endkolben, Pacinian and Golgi-Mazzoni corpuscles (CHOUCxkov , 1978). On the other hand varicosity-like expansions of axon terminals within the corpuscle have been observed only in the lamellated mechanoreceptors of reptilian skin (DURING , 1973).…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the interlamellar space of the Herbst corpuscle contains collagen fibrils, but not basal lamina (ANDERSEN and NAFSTAD , 1968;SAXOD, 1978). The lamellar cells in the mechanoreceptors described above were thought to have been derived from the Schwann cell (HALATA , 1975;IDE, 1977;SAXOD, 1978). The lack of basal lamina and the incompleteness of the capsule of the lamellated corpuscle in turtle lymph heart coincide with the findings in the Meissner corpuscle HALATA, 1975;IDE, 1976) and the lamellated nerve endings in reptilian skin (DURING, 1973(DURING, , 1974.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study it is uncertain whether the capsule is continuous with the perineurium. The lamellated corpuscles as described above have been considered to be mechanoreceptors (probably pressoreceptors in this case) which have rapidly-adapting characteristics (MUNGER, 1971;DURING and SEILER, 1974;CHOUCHKOV, 1978;SAXOD, 1978). Although physiological details of the pressoreceptor of a reptilian lymph heart have not been studied, the receptor seems to contribute to the control of the lymph heart activity.…”

Section: Discussionmentioning

confidence: 99%

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