Development of Core@Shell γ-Fe₂O₃@Mn_xO_y@SiO₂ Nanoparticles for Hyperthermia, Targeting, and Imaging Applications

Abstract

Monodispersed core@shell γ-Fe2O3@Mn x O y nanoparticles have been prepared through thermolysis of iron and manganese oleate. Further, these prepared nanoparticles are coated with biocompatible substances such as silica and polyethylene glycol. These particles are highly biocompatible for different cell lines such as normal and cancer cell lines. The nanoparticles are used as hyperthermia agents, and successful hyperthermia treatment in cancer cells is carried out. As compared to γ-Fe2O3@SiO2, γ-Fe2O3@Mn x O y @SiO2 shows the enhanced killing of cancer cells through hyperthermia. In order to make them potential candidates for targeting to cancer cells, folic acid (FA) is tagged to the nanoparticles. Fluorescein isothiocyanate (FITC) is also tagged onto these nanoparticles for imaging. The developed γ-Fe2O3@Mn x O y @SiO2 nanoparticle can act as a single entity for therapy through AC magnetic field, imaging through FITC and targeting through folic acid simultaneously. This is the first report on this material, which is highly biocompatible for hyperthermia, imaging, and targeting.

Review on Medical Applications of Manganese Oxide (Mn2+, Mn3+, and Mn4+) Magnetic Nanoparticles

“…In another work, MnFe 2 O 4 NPs were modified with polyethylene glycol (PEG) loaded with glucose oxidase and exhibited good magnetic susceptibility with M s of ∼75 emu/g and SAR of 296 W/g [124]. Joshi et al [125] developed Core@Shell NPs, i.e., γ-Fe 2 O 3 @Mn x O y @SiO 2 by thermolysis of iron and manganese oleate. The hyperthermia studies of the prepared on γ-Fe 2-O 3 @Mn x O y @SiO 2 MCF-7 and A549 cell lines revealed that cell viability is decreased after treating the cells with an AC magnetic field.…”

The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review

“…These advancements in nanomedicine have yielded promising results in preclinical and clinical trials of chemotherapy [ 10 , 11 ], RT [ 12 , 13 ], and HT [ 14 , 15 ], opening up new possibilities for cancer diagnosis and treatment. NP-based strategies can also be applied for simultaneous imaging with MRI [ 16 ] or CT [ 17 ], offering dual functionality.…”