Development of contact-killing non-leaching antimicrobial guanidyl-functionalized polymers via click chemistry

Abstract

A new contact-killing and non-leaching antimicrobial polymer was prepared by a robust, efficient and orthogonal click-chemistry.

In Vitro and In Vivo Evaluation of the Toxic Effects of Dodecylguanidine Hydrochloride

“…Cationic active biocides, such as quaternary ammonium compounds (QACs), guanidine derivatives, and amphoteric surfactants, have been widely used for a long time. Many biocides use high binding affinity with a containing cationic group to capture negatively charged bacteria, resulting in disruption of their membrane [ 41 , 42 , 43 , 44 ]. Having a highly positively charged part is the typical chemical characteristic of guanidine-based chemicals, and it is well known that positively charged parts of chemicals can penetrate the cell membrane easily, inducing systemic toxicity in vivo [ 45 , 46 , 47 ].…”

Development of self-stratified antibacterial polymers via click chemistry

“…The T g s of PU-F were larger than PU-Al, and they increased with the proceeding of click reaction, which was attributed to the formation of rigid triazole rings by CuAAC click reaction. 23,39 TGA results provide the information, including volatile content and decomposition temperature (T d ). The degradation of polyurethane is a step-by-step process.…”

“…21,22 Therefore, fabricating the antibacterial materials with contact-killing capability (without releasing toxic agents) is a concern. 23,24 Polyurethanes are a versatile class of materials due to the ability to tailor their properties via introducing wide range of chemicals into the polyurethane composition. [25][26][27] QACs graed antibacterial polymers have been successfully prepared and studied extensively.…”

Electricity generation in microbial fuel cell from wet torrefaction wastewater and locally developed corncob electrodes

“…Additionally, it is also "sterile" containing no living agents which might serve as contaminants/competitors during the MFC operation as compared to wastewaters of other origins such as the domestic wastewater and biogasdigestate. This is simply because the wet torrefaction wastewater resulted from a thermal process carried out at 200 • C to 300 • C [23], which eliminates all living agents [24] This study focused on the conversion of dry solid biomass of corncobs by slow pyrolysis into pyrochar which was then activated by steam. Electrodes were prepared from the steam-activated pyrochar and their performance in electricity generation was assessed in a dual-chambered MFC.…”

“…Additionally, it is also “sterile” containing no living agents which might serve as contaminants/competitors during the MFC operation as compared to wastewaters of other origins such as the domestic wastewater and biogas‐digestate. This is simply because the wet torrefaction wastewater resulted from a thermal process carried out at 200°C to 300°C [23], which eliminates all living agents [24]…”