Development of conditioned place preference induced by intra-accumbens infusion of amphetamine is attenuated by co-infusion of dopamine D1 and D2 receptor antagonists

Liao, Ruey-Ming

doi:10.1016/j.pbb.2008.01.009

Cited by 23 publications

(15 citation statements)

References 34 publications

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“…In this study, we replicate our previous finding that AMPH exposure induces CPP in male prairie voles (22) and demonstrate that D1R activation in the NAcc is necessary for this behavior, a result consistent with studies in other rodent species (28). This finding, together with earlier studies, suggests that distinct DAergic mechanisms in the NAcc regulate AMPH-and partner-motivated behaviors: AMPH-motivated behavior (CPP) is mediated by D1R, whereas partner-motivated behavior (partner preferences) is facilitated by D2R activation and inhibited by D1R activation within the NAcc (13)(14)(15).…”

Section: Discussionsupporting

confidence: 91%

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Liang

Aragona

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

119

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The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating, a behavior in which central dopamine (DA) has been implicated. Here, we used male prairie voles to examine the effects of drug exposure on pair bonding and related neural circuitry. In our first experiment, amphetamine (AMPH) motivated behavior was examined using a conditioned place preference (CPP) paradigm and was shown to be mediated by activation of D1-like DA receptors. Next, we examined the effects of repeated AMPH exposure on pair bonding. Intact and saline pretreated control males displayed mating-induced partner preferences, whereas males pretreated with AMPH at the doses effective to induce CPP failed to show mating-induced partner preferences. Such AMPH treatment also enhanced D1, but not D2, DA receptor expression in the nucleus accumbens (NAcc). Furthermore, pharmacological blockade of D1-like DA receptors in the NAcc rescued mating-induced partner preferences in AMPH-treated males. Together, our data indicate that repeated AMPH exposure may narrow the behavioral repertoire of male prairie voles via a DA receptor-specific mechanism in the NAcc, resulting in the impairment of pair bond formation.vole | CPP | D1 Receptor I t is widely accepted that motivated and emotional behaviors that promote fitness are regulated by brain reward circuitry including the mesolimbic dopamine (DA) system (1, 2). Although this system is often implicated in food intake and sexual behavior (3, 4), it has also been implicated in other naturally occurring motivated behaviors, such as social play between juveniles and social bonding between parent and offspring (5-9). Often underrepresented in research are the social bonds formed between adult mates, i.e., pair bonds. Recent investigation using a socially monogamous rodent species, the prairie vole (Microtus ochrogaster) (10-12), indicate that a great deal of the neural regulation underlying pair bond formation and maintenance occurs within the nucleus accumbens (NAcc) (13-15)-a mesolimbic brain region critical for mediating motivated behaviors (1, 2, 16).Although motivational circuitry evolved to promote fitness enhancing behavior such as feeding, mating, and social bonding (1, 17), it is vulnerable to artificial usurpation by drugs of abuse (8). For example, administration of psychostimulant drugs of abuse, such as cocaine and amphetamine (AMPH), results in persistent alterations of mesolimbic DA activity (18,19). The intense impact on this circuit by these and other addictive drugs has been suggested to decrease the perceived value of natural incentives (20), including those of a social nature (8). Although it is known that drug addicts show impaired social behavior (21), the neural regulation of interactions between drug experience and social attachment is poorly understood. This is because, in part, such interactions are difficult to model in traditional laboratory rodents that do not exhibit social bonding between adult conspecifics.The neurobiology of su...

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Section: Discussionsupporting

confidence: 91%

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Liang

Aragona

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

119

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“…Experiments 1 and 2 examined the effects of intra-Acb injection of the D1-receptor antagonist SCH23390 or the D2-receptor antagonist raclopride, respectively, on the acquisition of ethanol-induced CPP in DBA/2J mice, an inbred strain that is known to be especially sensitive to ethanol reward in this procedure (Cunningham, Niehus, Malott, & Prather, 1992). On the basis of previous studies we predicted that Acb D1-receptor blockade would interfere with CPP acquisition, but we were uncertain about effects of Acb D2-receptor blockade since previous CPP studies have shown both positive (Fenu et al, 2006; Liao, 2008; Kurokawa et al, 2012; Taslimi, Arezoomandan, Omranifard, Ghalandari-Shamami, Riahi, Vafaei, Rashidy-Pour & Haghparast, 2012) and negative (Baker, Khroyan, O'Dell, Fuchs & Neisewander, 1996; Liu et al, 2011; Spina et al, 2006) effects. Experiments 3 and 4 examined the effects of D1- and D2-receptor blockade on the expression of ethanol-induced CPP.…”

Section: Introduction1mentioning

confidence: 99%

Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior

Young

Dreumont

Cunningham

2014

Neurobiology of Learning and Memory

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These studies examined the roles of dopamine D1- and D2-like receptors within the nucleus accumbens (Acb) in the acquisition and expression of ethanol-induced (2 g/kg) conditioned place preference (CPP) in adult male DBA/2J mice. Bilateral intra-Acb infusions of the D1-like dopamine receptor antagonist SCH23390 (0.05, 0.5 µg/side) or the D2-like dopamine receptor antagonist raclopride (0.5–5.0 µg/side) were administered 30 min before each ethanol conditioning trial (acquisition studies) or before preference tests (expression studies). CPP was conditioned to tactile cues using an unbiased apparatus and procedure. Intra-Acb infusion of SCH23390 prevented CPP acquisition, whereas intra-Acb infusion of raclopride did not. Intra-Acb infusion of both antagonists, however, dose-dependently reduced ethanol-stimulated locomotor activity during conditioning. In contrast, intra-Acb antagonist infusion had no effect on ethanol CPP expression, suggesting that dopamine’s role in the Acb is limited to neurobiological processes engaged during the learning of the relationship between contextual cues and ethanol reward. Control experiments showed that intra-Acb injection of SCH23390 alone produced no place conditioning and did not interfere with the acquisition of conditioned place aversion induced by lithium chloride, suggesting that the antagonist’s effect on ethanol CPP was not due to a more general detrimental effect on associative learning. Overall, these data suggest that D1-like (but not D2-like) dopamine Acb receptors play an important role in the learning of context-ethanol associations, either by modulating the magnitude of ethanol reward or the rate of learning about ethanol reward.

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“…In the present study, we hypothesized that adolescent APD therapy would also have long-term effects on the brain’s reward system, due to : (1) the DAergic activities of the drugs; (2) the continuing development and plasticity of DAergic transmission during adolescence (Andersen et al, 2000; Brenhouse et al, 2008; Wahlstrom et al, 2010; Andersen and Navalta, 2011); (3) the importance of DA as a regulator of developmental processes; (4) the pivotal role of DA signalling in the mature reward system (Di Ciano et al, 2001; Parkinson et al, 2002). We focused on the nucleus accumbens core (NAcC) because it is a key node in the neural network mediating the acquisition of conditioned appetitive responses (Parkinson et al, 2000; Cardinal et al, 2002), via DA-dependent mechanisms (Parkinson et al, 2002; Liao, 2008; Vidal-Infer et al, 2012). Here, we demonstrate that adult rats treated with Ola as adolescents, using a dosing regimen designed to optimize translational relevance, exhibit enduring, previously unrecognized changes in reward system function and in DAergic neurotransmission in the NAcC.…”

Section: Introductionmentioning

confidence: 99%

Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function

Vinish

Elnabawi

Milstein

et al. 2013

International Journal of Neuropsychopharmacology

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Antipsychotic drugs are increasingly used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of early life antipsychotic drug (APD) treatment. Most APDs are potent antagonists or partial agonists of dopamine (DA) D2 receptors ; atypical APDs also have multiple serotonergic activities. DA and serotonin regulate many neurodevelopmental processes. Thus, early life APD treatment can, potentially, perturb these processes, causing long-term behavioural and neurobiological sequelae. We treated adolescent, male rats with olanzapine (Ola) on post-natal days 28–49, under dosing conditions that approximate those employed therapeutically in humans. As adults, they exhibited enhanced conditioned place preference for amphetamine, as compared to vehicle-treated rats. In the nucleus accumbens core, DA D1 receptor binding was reduced, D2 binding was increased and DA release evoked by electrical stimulation of the ventral tegmental area was reduced. Thus, adolescent Ola treatment enduringly alters a key behavioural response to rewarding stimuli and modifies DAergic neurotransmission in the nucleus accumbens. The persistence of these changes suggests that even limited periods of early life Ola treatment may induce enduring changes in other reward-related behaviours and in behavioural and neurobiological responses to therapeutic and illicit psychotropic drugs. These results underscore the importance of improved understanding of the enduring sequelae of paediatric APD treatment as a basis for weighing the benefits and risks of adolescent APD therapy, especially prophylactic treatment in high-risk, asymptomatic patients.

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Development of conditioned place preference induced by intra-accumbens infusion of amphetamine is attenuated by co-infusion of dopamine D1 and D2 receptor antagonists

Cited by 23 publications

References 34 publications

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior

Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function

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