Development of computational pregnant female and fetus models and assessment of radiation dose from positron-emitting tracers

Xie, Tianwu; Zaidi, Habib

doi:10.1007/s00259-016-3448-8

Cited by 18 publications

(22 citation statements)

References 27 publications

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“…Xie et al [21] developed a complete set of embryo/fetus models at various gestation periods with 25 identified tissues according to reference data recommended by the ICRP publication 89 [22], representing the anatomy of the developing embryo/fetus. Firstly, they demonstrated that the fetal-effective doses are significantly higher in the first trimester than at other gestational periods because the fetal weight is lower at the beginning of pregnancy.…”

Section: Fetal Radiation Dose and Potential Damagesmentioning

confidence: 99%

Use of Positron Emission Tomography for Pregnancy-Associated Cancer Assessment: A Review

Parpinel

Laudani

Giunta

et al. 2022

JCM

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Background. Positron emission tomography (PET) has proven clinical utility both in the initial and relapse staging phase, but this technique is controversial during pregnancy. The objective of this review is to provide a compendium of available information on the use of PET during pregnancy. Materials and methods. A systematic literature review was conducted from 1 January 2004 until 20 May 2021. A total of 4 small series and 9 case reports consisting of 25 cases were selected. Results. During the first trimester, the fetus is most sensitive to ionization damage, so lower doses are recommended (2.6E-02 mGy/MBq). Fetal-effective doses are higher in this period and the average fetal dose (4.06 ± 3.22 mGy) remains significantly below the threshold for deterministic effects. During the second and third trimesters, recommended doses are higher (1.4E-02 mGy/MBq at 6 months, and 6.9E-03 mGy/MBq at 9 months of gestation). 18F-FDG activity was distributed to the whole fetus with a prevalence of myocardial tissue in seven cases. The use of special precautions, such as PET-magnetic resonance (MR) and urinary bladder catheterization, reduces the amount of radioactive tracer. Breastfeeding interruption is not recommended. Conclusions. 18F-FDG PET is not contraindicated in pregnancy, but multidisciplinary discussion is necessary and strict precautions are recommended.

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Section: Fetal Radiation Dose and Potential Damagesmentioning

confidence: 99%

Use of Positron Emission Tomography for Pregnancy-Associated Cancer Assessment: A Review

Parpinel

Laudani

Giunta

et al. 2022

JCM

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“…Our standardized pregnant female model with twins at the 25th wk of gestation was based on the International Commission on Radiological Protection (ICRP) computational pregnant female phantom at the 25th wk of gestation (17), which was developed using the mother torso and internal organs of the Rensselaer Polytechnic Institute phantoms (RPI-P) (25), the fetal and mother numeric models of Telecom ParisTech (26), the Katja model (27), and the newborn model of Helmholtz Zentrum München (28). The 25th-wk twins phantom was based on the fetal and mother numeric models and the Katja model.…”

Section: Standardized Computational Model For Twinsmentioning

confidence: 99%

“…As shown in Figure 4A, for the same organ, the estimated selfabsorbed S value of the lower fetus was about 29% smaller than the value of the upper fetus. Indeed, the self-absorbed S values of fetal organs decrease when fetal weight increases (17). The crossabsorbed S values were obtained assuming uniform activity in all maternal source tissues.…”

Section: Absorbed Doses From the Pet Componentmentioning

confidence: 99%

“…Estimating the fetal dose is, however, a challenging task, because of the difficulties associated with direct measurement of energy deposition and the irregular shape of the fetal body. Various approaches have been adopted to estimate the fetal dose, including Monte Carlo simulations using computational anthropomorphic models (7,(9)(10)(11)(12)(13)(14)(15)(16)(17) and experimental measurements using physical phantoms with embedded dosimeters (18)(19)(20)(21). However, these approaches inherently bear several limitations, such as the difficulty of constructing patient-specific computational models and of matching anthropomorphic physical phantoms to the size and location of the fetus within the maternal body (22).…”

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confidence: 99%

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Patient-Specific Computational Model and Dosimetry Calculations for PET/CT of a Patient Pregnant with Twins

Xie

Zanotti‐Fregonara

Edet-Sanson³

et al. 2018

J Nucl Med

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The radiation dose delivered to pregnant patients during radiologic imaging procedures raises health concerns because the developing embryo and fetus are considered to be highly radiosensitive. To appropriately weigh the diagnostic benefits against the radiation risks, the radiologist needs reasonably accurate and detailed estimates of the fetal dose. Expanding our previously developed series of computational phantoms for pregnant women, we here describe a personalized model for twin pregnancy, based on an actual clinical scan. The model is based on a standardized hybrid pregnant female and fetus phantom and on a clinical case of a patient who underwent anF-FDG PET/CT scan while expecting twins at 25 weeks' gestation. This model enabled us to produce a realistic physical representation of the pregnant patient and to estimate the maternal and fetal organ doses from the F-FDG and CT components. The Monte Carlo N-Particle Extended general-purpose code was used for radiation transport simulation. The F-FDG doses for the 2 fetuses were 3.78 and 3.99 mGy, and the CT doses were 0.76 and 0.70 mGy, respectively. Therefore, the relative contribution ofF-FDG and CT to the total dose to the fetuses was about 84% and 16%, respectively. Meanwhile, for F-FDG, the calculated personalized absorbed dose was about 40%-50% higher than the doses reported by other dosimetry computer software tools. Our approach to constructing personalized computational models allows estimation of a patient-specific radiation dose, even in cases with unusual anatomic features such as a twin pregnancy. Our results also show that, even in twins, the fetal organ doses from both F-FDG and CT present a certain variability linked to the anatomic characteristics. The CT fetal dose is smaller than theF-FDG PET dose.

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“…Different techniques have been adopted for estimating the conceptus dose in pregnant patients, including Monte Carlo calculations using dedicated computational anthropomorphic models [2,[13][14][15][16][17][18][19][20][21][22][23][24] and experimental measurements using physical phantoms [25][26][27][28]. However, these techniques naturally bear many limitations, including the difficulty of accurate modeling of individual patient's anatomy considering the location, shape and size of internal organs, and the uterus/fetus within the target region of the pregnant patient's body [29].…”

Section: Introductionmentioning

confidence: 99%

Estimation of the radiation dose in pregnancy: an automated patient-specific model using convolutional neural networks

Xie

Zaidi

2019

Eur Radiol

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Objectives The conceptus dose during diagnostic imaging procedures for pregnant patients raises health concerns owing to the high radiosensitivity of the developing embryo/fetus. The aim of this work is to develop a methodology for automated construction of patient-specific computational phantoms based on actual patient CT images to enable accurate estimation of conceptus dose. Methods We developed a 3D deep convolutional network algorithm for automated segmentation of CT images to build realistic computational phantoms. The neural network architecture consists of analysis and synthesis paths with four resolution levels each, trained on manually labeled CT scans of six identified anatomical structures. Thirty-two CT exams were augmented to 128 datasets and randomly split into 80%/20% for training/testing. The absorbed doses for six segmented organs/tissues from abdominal CT scans were estimated using Monte Carlo calculations. The resulting radiation doses were then compared between the computational models generated using automated segmentation and manual segmentation, serving as reference. Results The Dice similarity coefficient for identified internal organs between manual segmentation and automated segmentation results varies from 0.92 to 0.98 while the mean Hausdorff distance for the uterus is 16.1 mm. The mean absorbed dose for the uterus is 2.9 mGy whereas the mean organ dose differences between manual and automated segmentation techniques are 0.07%, − 0.45%, − 1.55%, − 0.48%, − 0.12%, and 0.28% for the kidney, liver, lung, skeleton, uterus, and total body, respectively. Conclusion The proposed methodology allows automated construction of realistic computational models that can be exploited to estimate patient-specific organ radiation doses from radiological imaging procedures. Key Points • The conceptus dose during diagnostic radiology and nuclear medicine imaging procedures for pregnant patients raises health concerns owing to the high radiosensitivity of the developing embryo/fetus. • The proposed methodology allows automated construction of realistic computational models that can be exploited to estimate patient-specific organ radiation doses from radiological imaging procedures. • The dosimetric results can be used for the risk-benefit analysis of radiation hazards to conceptus from diagnostic imaging procedures, thus guiding the decision-making process.

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Development of computational pregnant female and fetus models and assessment of radiation dose from positron-emitting tracers

Cited by 18 publications

References 27 publications

Use of Positron Emission Tomography for Pregnancy-Associated Cancer Assessment: A Review

Use of Positron Emission Tomography for Pregnancy-Associated Cancer Assessment: A Review

Patient-Specific Computational Model and Dosimetry Calculations for PET/CT of a Patient Pregnant with Twins

Estimation of the radiation dose in pregnancy: an automated patient-specific model using convolutional neural networks

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