Development of Computational Correlations among Known Drug Scaffolds and their Target-Specific Non-Coding RNA Scaffolds of Alzheimer's Disease
Debjani Roy,
Shymodip Kundu,
Swayambhik Mukherjee
Abstract:Background:
Alzheimer's disease is the most common neurodegenerative disorder. Recent development in sciences has also identified the pivotal role of microRNAs (miRNAs) in AD
pathogenesis.
Objectives:
We proposed a novel method to identify AD pathway-specific statistically significant
miRNAs from the targets of known AD drugs. Moreover, microRNA scaffolds and corresponding
drug scaffolds of different pathways were also discovered.
Material and Methods:
A Wilcoxon signed-rank test was performed to identify … Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.